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<h1><a href="http://piq.csail.mit.edu"><font color="#000000">PIQ: Protein Interaction Quantification</font></a></h1>

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<td class="toplinks"><a href="index.html">PIQ Overview</a></td>
<td class="toplinks"><a href="algorithm.html">Algorithm Design</a></td>
<td class="toplinks"><a href="results.html">Binding calls</a></td>
<td class="toplinks"><a href="download.html">Code</a></td>
<td class="toplinks"><a href="contact.html">Contact</a></td>
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<p>An algorithmic description of PIQ can be found in detail in Supplementary Material of the submitted document.  In brief, the PIQ algorithm has been tailored to meet several design goals:<br>
<ul>
<li>Resistance to low coverage and noisy data
<li>Integrate multiple experiments, whether replicates or time-series data
<li>High spatial accuracy
<li>Robust worst case behavior
<li>Scalability to thousands of motifs genome-wide
</ul>
To meet these goals our algorithm can be separated into
<ul>
<li>A generative model for reads
<li>A cross-experiment and cross-strand correlation model
<li>A TF binding model
<li>An inference procedure
</ul>
<p>








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