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Molybdenum cofactor biosynthesis (R-HSA-947581) #267

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ukemi opened this issue Jun 16, 2023 · 0 comments
Open
4 tasks

Molybdenum cofactor biosynthesis (R-HSA-947581) #267

ukemi opened this issue Jun 16, 2023 · 0 comments

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@ukemi
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ukemi commented Jun 16, 2023

  • Make mouse models- Interesting that despite an upstream branch, I think it is appropriate to make a single branched model because the two branches generate separate entities for the next reaction.
  • R-HSA-947535 would be better mapped to cyclic pyranopterin monophosphate synthase activity (GO:0061799).
  • I can't get the full text, but PMID: 22270318 may show that the non-receptor clustering activity of gephyrin is in the cytosol.
  • Can we refine R-ALL-947539 to be Mo-molybdopterin cofactor (CHEBI:21437) rather than molybdopterin cofactor (CHEBI:25372)? According to CHEBI, the less specific one can have a tungsten coordinating the cofactor, but I think this is specific for molybdenum.
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