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NTR: [RNA polymerase II transcription elongation surveillance] #29516

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sylvainpoux opened this issue Jan 6, 2025 · 3 comments
Open

NTR: [RNA polymerase II transcription elongation surveillance] #29516

sylvainpoux opened this issue Jan 6, 2025 · 3 comments
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@sylvainpoux
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Hi GO,
I would need a new term for a transcription elongation quality comtrol process. The integrator complex mediates transcription termination of transcripts that are unfavorably configured for transcriptional elongation.

Thanks

Sylvain

Term: RNA polymerase II transcription elongation surveillance
Definition: A process that promotes premature RNA polymerase II transcription termination of transcripts that are unfavorably configured for transcriptional elongation.
child of GO:0006369 termination of RNA polymerase II transcription
child of GO:0034243; P:regulation of transcription elongation by RNA polymerase II
PubMed=33385327
PubMed=34762484

@raymond91125
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@sylvainpoux I collected related issues into a Project https://github.com/orgs/geneontology/projects/228 to help coordinate discussions and actions. Please let me know if there are other tickets that should be included. Thanks.

@sylvainpoux
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Hi @raymond91125, thanks for the information. For the moment I don't need more terms. The only issue is that I 'store' a lot of curation work waiting for new terms. If the discussion takes long, it will be difficult for me to keep up with curation work and GO-CAM models that are pending.

Thanks

Sylvain

@raymond91125
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Understood. I've made terms for the INTAC complex and integrator complex assembly. For the process terms, I think the decision has wider implications. I will reach out to @pgaudet for prioritization. Apologies for the delay.

Hi @raymond91125, thanks for the information. For the moment I don't need more terms. The only issue is that I 'store' a lot of curation work waiting for new terms. If the discussion takes long, it will be difficult for me to keep up with curation work and GO-CAM models that are pending.

Thanks

Sylvain

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