diff --git a/api/http/.pre-commit-config.yaml b/api/http/.pre-commit-config.yaml
index 1fa3a112e2..38b2ed0244 100644
--- a/api/http/.pre-commit-config.yaml
+++ b/api/http/.pre-commit-config.yaml
@@ -29,8 +29,15 @@ repos:
         language: system
         types: [ python ]
 
-
--   repo:  https://github.com/pre-commit/mirrors-mypy
-    rev: "v0.910"
+-   repo: local
     hooks:
     -   id: mypy
+        name: mypy
+        language: system
+        entry: mypy
+        args:
+            [
+                "--config-file",
+                "api/http/mypy.ini"
+            ]
+        types: [ python ]
diff --git a/api/http/Dockerfile b/api/http/Dockerfile
index 4b8985d078..305f93eb61 100644
--- a/api/http/Dockerfile
+++ b/api/http/Dockerfile
@@ -16,7 +16,7 @@
 # limitations under the License.
 
 # For test purposes
-FROM python:3.9-slim-buster as indigo_service_dev
+FROM python:3.10-slim-buster as indigo_service_dev
 
 RUN mkdir -p /opt/indigo
 WORKDIR /opt/indigo
diff --git a/api/http/indigo_service/indigo_http.py b/api/http/indigo_service/indigo_http.py
index 5cfb8c8ce0..89d9a6f31a 100644
--- a/api/http/indigo_service/indigo_http.py
+++ b/api/http/indigo_service/indigo_http.py
@@ -60,6 +60,7 @@ def compounds(
         jsonapi.ValidationRequest,
         jsonapi.CompoundConvertRequest,
         jsonapi.RenderRequest,
+        jsonapi.PKARequest,
     ],
 ) -> List[Tuple[str, jsonapi.CompoundFormat]]:
     return service.extract_pairs(request.data.attributes.compound)
@@ -190,6 +191,27 @@ def descriptors(
     return jsonapi.make_descriptor_response(results)
 
 
+@app.post(f"{BASE_URL_INDIGO}/pka", response_model=jsonapi.PKAResponse)
+def pka(request: jsonapi.PKARequest) -> jsonapi.PKAResponse:
+    compound, *_ = service.extract_compounds(compounds(request))
+    if request.data.attributes.pka_model == jsonapi.PKAModel.ADVANCED:
+        indigo().setOption("pKa-model", jsonapi.PKAModel.ADVANCED.value)
+    pka_model_level = request.data.attributes.pka_model_level
+    pka_model_min_level = request.data.attributes.pka_model_min_level
+    pka_values = jsonapi.AtomToValueContainer()
+    for atom in compound.iterateAtoms():
+        pka_values.mappings.append(
+            jsonapi.AtomToValueMapping(
+                index=atom.index(),
+                symbol=atom.symbol(),
+                value=compound.getAcidPkaValue(
+                    atom, pka_model_level, pka_model_min_level
+                ),
+            )
+        )
+    return jsonapi.make_pka_response(pka_values)
+
+
 @app.post(
     f"{BASE_URL_INDIGO}/commonBits",
     response_model=jsonapi.CommonBitsResponse,
@@ -209,9 +231,7 @@ def common_bits(
 
 
 @app.post(f"{BASE_URL_INDIGO}/render", response_model=jsonapi.RenderResponse)
-def render(
-    request: jsonapi.RenderRequest,
-) -> jsonapi.RenderResponse:
+def render(request: jsonapi.RenderRequest,) -> jsonapi.RenderResponse:
     compound, *_ = service.extract_compounds(compounds(request))
     output_format = request.data.attributes.outputFormat
     indigo_renderer = IndigoRenderer(indigo())
@@ -245,58 +265,3 @@ def run_debug() -> None:
 
 if __name__ == "__main__":
     run_debug()
-
-
-# TODO: /indigo/render with alternative responses types
-# @app.post(f"{BASE_URL_INDIGO}/render")
-# def render(
-#     request: jsonapi.RenderRequest,
-# ) -> Union[Response, FileResponse]:
-#     compound, *_ = service.extract_compounds(compounds(request))
-#     output_format = request.data.attributes.outputFormat
-#     indigo_renderer = IndigoRenderer(indigo())
-#     indigo().setOption(
-#         "render-output-format", jsonapi.rendering_formats.get(output_format)
-#     )
-#     options = request.data.attributes.options
-#     if options:
-#         for option, value in options.items():
-#             if option == "render-output-format":
-#                 raise HTTPException(
-#                     status_code=400, detail="Choose only one output format"
-#                 )
-#             indigo().setOption(option, value)
-#     if output_format == "image/png":
-#         result = indigo_renderer.renderToBuffer(compound).tobytes()
-#         response = Response(
-#             result,
-#             headers={"Content-Type": "image/png"}
-#         )
-#     elif output_format == "image/png;base64":
-#         result = indigo_renderer.renderToBuffer(compound).tobytes()
-#         decoded_image = base64.b64encode(result).decode("utf-8")
-#         image_base64 = f"data:image/png;base64,{decoded_image}"
-#         response = Response(
-#             image_base64,
-#             headers={"Content-Type": "image/png"}
-#         )
-#     elif output_format == "image/svg+xml":
-#         result = indigo_renderer.renderToString(compound)
-#         response = Response(
-#             result,
-#             headers={"Content-Type": "image/svg+xml"}
-#         )
-#     elif output_format == "application/pdf":
-#         result = indigo_renderer.renderToBuffer(compound).tobytes()
-#         response = Response(
-#             result, headers={
-#                 "Content-Type": "application/pdf",
-#                 "Content-Disposition": "attachment; filename=mol.pdf"
-#             }
-#         )
-#     else:
-#         raise HTTPException(
-#             status_code=400,
-#             detail=f"Incorrect output format {output_format}"
-#         )
-#     return response
diff --git a/api/http/indigo_service/jsonapi.py b/api/http/indigo_service/jsonapi.py
index 2a78df4f56..e441c9192f 100644
--- a/api/http/indigo_service/jsonapi.py
+++ b/api/http/indigo_service/jsonapi.py
@@ -515,8 +515,6 @@ class Descriptors(str, Enum):
     MONOISOTOPIC_MASS = "monoisotopicMass"
     MOST_ABUNDANT_MASS = "mostAbundantMass"
     NAME = "name"
-    GET_ACID_PKA_VALUE = "acidPkaValue"
-    GET_BASIC_PKA_VALUE = "basicPkaValue"
     GROSS_FORMULA = "grossFormula"
 
 
@@ -563,8 +561,6 @@ class DescriptorResultModel(BaseModel):
     monoisotopicMass: Optional[str]
     mostAbundantMass: Optional[str]
     name: Optional[str]
-    getAcidPkaValue: Optional[str]
-    getBasicPkaValue: Optional[str]
     grossFormula: Optional[str]
 
 
@@ -585,6 +581,55 @@ def make_descriptor_response(
 ]
 
 
+# PKA models
+
+
+class PKAType(str, Enum):
+    ACID = "acid"
+    BASIC = "basic"
+
+
+class PKAModel(str, Enum):
+    SIMPLE = "simple"
+    ADVANCED = "advanced"
+
+
+class PKARequestModel(BaseModel):
+    compound: CompoundObject
+    pka_model: PKAModel
+    pka_type: PKAType = PKAType.ACID
+    pka_model_level: int = 0
+    pka_model_min_level: int = 0
+
+
+class PKARequestModelType(BaseModel):
+    __root__ = "pka"
+
+
+class AtomToValueMapping(BaseModel):
+    index: int
+    symbol: str
+    value: float
+
+
+class AtomToValueContainer(BaseModel):
+    mappings: list[AtomToValueMapping] = []
+
+
+class PKAResultModelType(BaseModel):
+    __root__ = "pkaResult"
+
+
+PKARequest = Request[PKARequestModelType, PKARequestModel]
+PKAResponse = Response[PKAResultModelType, AtomToValueContainer]
+
+
+def make_pka_response(mappings: AtomToValueContainer) -> PKAResponse:
+    return PKAResponse(
+        **{"data": {"type": "pkaResult", "attributes": mappings}}
+    )
+
+
 # Render
 
 
@@ -618,8 +663,7 @@ class RenderResultModel(BaseModel):
 
 
 def make_render_response(
-    raw_image: bytes,
-    output_format: str,
+    raw_image: bytes, output_format: str
 ) -> RenderResponse:
     if output_format == "image/svg+xml":
         str_image = raw_image.decode("utf-8")
diff --git a/api/http/mypy.ini b/api/http/mypy.ini
index 072fef58ff..7f90aadf6b 100644
--- a/api/http/mypy.ini
+++ b/api/http/mypy.ini
@@ -2,6 +2,7 @@
 python_version = 3.9
 strict = True
 plugins = pydantic.mypy
+exclude = dist
 
 [mypy-indigo.*]
 ignore_missing_imports = True
diff --git a/api/http/requirements_dev.txt b/api/http/requirements_dev.txt
index c5101f66cf..4e5bc4d930 100644
--- a/api/http/requirements_dev.txt
+++ b/api/http/requirements_dev.txt
@@ -19,3 +19,4 @@ types-requests==2.26.3
 urllib3==1.26.7
 isort==5.9.3
 pylint==2.11.1
+mypy==0.910