diff --git a/src/coreclr/scripts/jitutil.py b/src/coreclr/scripts/jitutil.py
index 0f917e2958f5d2..a44b5e8605fc68 100644
--- a/src/coreclr/scripts/jitutil.py
+++ b/src/coreclr/scripts/jitutil.py
@@ -494,6 +494,8 @@ def determine_jit_name(host_os, target_os=None, host_arch=None, target_arch=None
     if use_cross_compile_jit or (host_arch != target_arch) or ((target_os is not None) and (host_os != target_os)):
         if target_arch.startswith("arm"):
             jit_os_name = "universal"
+        if target_arch.startswith("wasm"):
+            jit_os_name = "universal"
         elif target_os == "windows":
             jit_os_name = "win"
         elif target_os == "osx" or target_os == "linux":
diff --git a/src/coreclr/scripts/superpmi.py b/src/coreclr/scripts/superpmi.py
index 60f7f69b9be856..da10ef5dc50a6f 100644
--- a/src/coreclr/scripts/superpmi.py
+++ b/src/coreclr/scripts/superpmi.py
@@ -146,13 +146,13 @@
 
 host_os_help = "OS (windows, osx, linux). Default: current OS."
 
-arch_help = "Architecture (x64, x86, arm, arm64, loongarch64, riscv64). Default: current architecture."
+arch_help = "Architecture (x64, x86, arm, arm64, loongarch64, riscv64, wasm). Default: current architecture."
 
 target_os_help = "Target OS, for use with cross-compilation JIT (windows, osx, linux). Default: current OS."
 
-target_arch_help = "Target architecture, for use with cross-compilation JIT (x64, x86, arm, arm64, loongarch64, riscv64). Passed as asm diffs target to SuperPMI. Default: current architecture."
+target_arch_help = "Target architecture, for use with cross-compilation JIT (x64, x86, arm, arm64, loongarch64, riscv64, wasm). Passed as asm diffs target to SuperPMI. Default: current architecture."
 
-mch_arch_help = "Architecture of MCH files to download, used for cross-compilation altjit (x64, x86, arm, arm64, loongarch64, riscv64). Default: target architecture."
+mch_arch_help = "Architecture of MCH files to download, used for cross-compilation altjit (x64, x86, arm, arm64, loongarch64, riscv64, wasm). Default: target architecture."
 
 build_type_help = "Build type (Debug, Checked, Release). Default: Checked."
 
@@ -4675,7 +4675,7 @@ def verify_target_args():
                             lambda mch_arch: "Unknown mch_arch {}\nSupported architectures: {}".format(mch_arch, (", ".join(coreclr_args.valid_arches))),
                             modify_arg=lambda mch_arch: mch_arch if mch_arch is not None else coreclr_args.target_arch) # Default to `target_arch`
 
-        # For LoongArch64, RiscV64, assume we are doing altjit cross-compilation and set mch_arch to 'arch', and target_os to Linux.
+        # For LoongArch64, RiscV64 assume we are doing altjit cross-compilation and set mch_arch to 'arch', and target_os to Linux.
         if coreclr_args.target_arch == "loongarch64" or coreclr_args.target_arch == "riscv64":
             if coreclr_args.target_os == coreclr_args.host_os and coreclr_args.target_os != "linux":
                 logging.warning("Overriding 'target_os' to 'linux'")
@@ -4684,6 +4684,12 @@ def verify_target_args():
                 logging.warning("Overriding 'mch_arch' to '%s'", coreclr_args.arch)
                 coreclr_args.mch_arch = coreclr_args.arch
 
+        # For wasm assume we are doing altjit cross-compilation and set mch_arch to 'arch'
+        if coreclr_args.target_arch == "wasm":
+            if coreclr_args.mch_arch == coreclr_args.target_arch and coreclr_args.mch_arch != coreclr_args.arch:
+                logging.warning("Overriding 'mch_arch' to '%s'", coreclr_args.arch)
+                coreclr_args.mch_arch = coreclr_args.arch
+
     def verify_superpmi_common_args():
 
         coreclr_args.verify(args,
diff --git a/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.cpp b/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.cpp
index a9867225e512f0..5c8b3e559215d9 100644
--- a/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.cpp
+++ b/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.cpp
@@ -248,6 +248,8 @@ static SPMI_TARGET_ARCHITECTURE SpmiTargetArchitecture = SPMI_TARGET_ARCHITECTUR
 static SPMI_TARGET_ARCHITECTURE SpmiTargetArchitecture = SPMI_TARGET_ARCHITECTURE_LOONGARCH64;
 #elif defined(TARGET_RISCV64)
 static SPMI_TARGET_ARCHITECTURE SpmiTargetArchitecture = SPMI_TARGET_ARCHITECTURE_RISCV64;
+#elif defined(TARGET_WASM32)
+static SPMI_TARGET_ARCHITECTURE SpmiTargetArchitecture = SPMI_TARGET_ARCHITECTURE_WASM32;
 #else
 #error Unsupported architecture
 #endif
diff --git a/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.h b/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.h
index 26a59a60981eee..26a85de9c170f9 100644
--- a/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.h
+++ b/src/coreclr/tools/superpmi/superpmi-shared/spmiutil.h
@@ -63,7 +63,8 @@ enum SPMI_TARGET_ARCHITECTURE
     SPMI_TARGET_ARCHITECTURE_ARM64,
     SPMI_TARGET_ARCHITECTURE_ARM,
     SPMI_TARGET_ARCHITECTURE_LOONGARCH64,
-    SPMI_TARGET_ARCHITECTURE_RISCV64
+    SPMI_TARGET_ARCHITECTURE_RISCV64,
+    SPMI_TARGET_ARCHITECTURE_WASM32,
 };
 
 SPMI_TARGET_ARCHITECTURE GetSpmiTargetArchitecture();
@@ -72,7 +73,8 @@ void SetSpmiTargetArchitecture(SPMI_TARGET_ARCHITECTURE spmiTargetArchitecture);
 inline bool IsSpmiTarget32Bit()
 {
     return (GetSpmiTargetArchitecture() == SPMI_TARGET_ARCHITECTURE_X86) ||
-           (GetSpmiTargetArchitecture() == SPMI_TARGET_ARCHITECTURE_ARM);
+           (GetSpmiTargetArchitecture() == SPMI_TARGET_ARCHITECTURE_ARM) ||
+           (GetSpmiTargetArchitecture() == SPMI_TARGET_ARCHITECTURE_WASM32);
 }
 
 inline bool IsSpmiTarget64Bit()
diff --git a/src/coreclr/tools/superpmi/superpmi/commandline.cpp b/src/coreclr/tools/superpmi/superpmi/commandline.cpp
index 6fd0acfcae6922..cf27a6b186e51e 100644
--- a/src/coreclr/tools/superpmi/superpmi/commandline.cpp
+++ b/src/coreclr/tools/superpmi/superpmi/commandline.cpp
@@ -128,7 +128,7 @@ void CommandLine::DumpHelp(const char* program)
     printf("\n");
     printf(" -target <target>\n");
     printf("     Specifies the target architecture if doing cross-compilation.\n");
-    printf("     Allowed <target> values: x64, x86, arm, arm64, loongarch64, riscv64\n");
+    printf("     Allowed <target> values: x64, x86, arm, arm64, loongarch64, riscv64, wasm\n");
     printf("     Used by the assembly differences calculator; to determine a default JIT dll name;\n");
     printf("     and to avoid treating mismatched cross-compilation replay as failure.\n");
     printf("\n");
@@ -689,7 +689,9 @@ bool CommandLine::Parse(int argc, char* argv[], /* OUT */ Options* o)
             (0 != _stricmp(o->targetArchitecture, "arm")) &&
             (0 != _stricmp(o->targetArchitecture, "arm32")) &&
             (0 != _stricmp(o->targetArchitecture, "loongarch64")) &&
-            (0 != _stricmp(o->targetArchitecture, "riscv64")))
+            (0 != _stricmp(o->targetArchitecture, "riscv64")) &&
+            (0 != _stricmp(o->targetArchitecture, "wasm")) &&
+            (0 != _stricmp(o->targetArchitecture, "wasm32")))
         {
             LogError("Illegal target architecture specified with -target.");
             DumpHelp(argv[0]);
diff --git a/src/coreclr/tools/superpmi/superpmi/jitinstance.cpp b/src/coreclr/tools/superpmi/superpmi/jitinstance.cpp
index 09e7e14cc9d112..5caefae5767fa0 100644
--- a/src/coreclr/tools/superpmi/superpmi/jitinstance.cpp
+++ b/src/coreclr/tools/superpmi/superpmi/jitinstance.cpp
@@ -281,30 +281,34 @@ ReplayResults JitInstance::CompileMethod(MethodContext* MethodToCompile, int mcI
 
             switch (pParam->pThis->mc->repGetExpectedTargetArchitecture())
             {
-                case IMAGE_FILE_MACHINE_AMD64:
+                case CORINFO_ARCH_X64:
                     matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_AMD64);
                     break;
 
-                case IMAGE_FILE_MACHINE_I386:
+                case CORINFO_ARCH_X86:
                     matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_X86);
                     break;
 
-                case IMAGE_FILE_MACHINE_ARMNT:
+                case CORINFO_ARCH_ARM:
                     matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_ARM);
                     break;
 
-                case IMAGE_FILE_MACHINE_ARM64:
+                case CORINFO_ARCH_ARM64:
                     matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_ARM64);
                     break;
 
-                case IMAGE_FILE_MACHINE_LOONGARCH64:
+                case CORINFO_ARCH_LOONGARCH64:
                     matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_LOONGARCH64);
                     break;
 
-                case IMAGE_FILE_MACHINE_RISCV64:
+                case CORINFO_ARCH_RISCV64:
                     matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_RISCV64);
                     break;
 
+                case CORINFO_ARCH_WASM32:
+                    matchesTargetArch = (targetArch == SPMI_TARGET_ARCHITECTURE_WASM32);
+                    break;
+
                 default:
                     LogError("Unknown target architecture");
                     break;
diff --git a/src/coreclr/tools/superpmi/superpmi/superpmi.cpp b/src/coreclr/tools/superpmi/superpmi/superpmi.cpp
index e7b62be6585330..ded4f00e92a775 100644
--- a/src/coreclr/tools/superpmi/superpmi/superpmi.cpp
+++ b/src/coreclr/tools/superpmi/superpmi/superpmi.cpp
@@ -62,6 +62,10 @@ void SetSuperPmiTargetArchitecture(const char* targetArchitecture)
         {
             SetSpmiTargetArchitecture(SPMI_TARGET_ARCHITECTURE_RISCV64);
         }
+        else if (0 == _stricmp(targetArchitecture, "wasm") || (0 == _stricmp(targetArchitecture, "wasm32")))
+        {
+            SetSpmiTargetArchitecture(SPMI_TARGET_ARCHITECTURE_WASM32);
+        }
         else
         {
             LogError("Illegal target architecture '%s'", targetArchitecture);