diff --git a/src/loci/formats/S3FileSystemStore.java b/src/loci/formats/S3FileSystemStore.java
index 7ad06af..cad86d6 100644
--- a/src/loci/formats/S3FileSystemStore.java
+++ b/src/loci/formats/S3FileSystemStore.java
@@ -102,7 +102,6 @@ private void setupClient() {
         client = AmazonS3ClientBuilder.standard()
           .withEndpointConfiguration(new AwsClientBuilder.EndpointConfiguration(endpoint, "auto"))
           .withPathStyleAccessEnabled(true)
-          .withRegion(Regions.DEFAULT_REGION) // Ignored but required by the client
           .withCredentials(new AWSStaticCredentialsProvider(new AnonymousAWSCredentials())).build();
       } catch (Exception e) {
         LOGGER.info("Exception caught while constructing S3 client");