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Refactor models.entities.gene_region.py #28

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laurensvdwiel opened this issue Sep 6, 2018 · 0 comments

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laurensvdwiel commented Sep 6, 2018

For future maintainability it is better if gene_region is refactored in the following manner:

Switch use of mapping objects to Codon object
Use the Codon objects with variants to create SingleNucleotideVariant classes
Add a pandas.Dataframe for the gene_region, representing each codon per row with tolerance (based on gnomad) annotated
Add a pandas.Dataframe for all clinvar variants
Allow gene_regions be reconstructed from tsv files (like MetaDomain) existing from codon and SingleNucleotideVariant classes

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