diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6b0a152fa..1886d5ec8 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,7 @@
 # CHANGELOG
 
+ * Added regular expression support to remove_compile_flags (#303)
+ * Fixed repeated comments in sequence diagrams (#301)
  * Added regular expression support to glob patterns (#299)
  * Enabled relative link patterns in generate_links option (#297)
  * Added advanced diagram filter config with anyof and allof operators (#289)
diff --git a/docs/common_options.md b/docs/common_options.md
index 175295829..1fd89c6ac 100644
--- a/docs/common_options.md
+++ b/docs/common_options.md
@@ -219,6 +219,14 @@ remove_compile_flags:
   - -I/usr/include
 ```
 
+`remove_compile_flags` also accepts regular expression, so a single entry can
+remove a whole set of flags, e.g.:
+
+```yaml
+remove_compile_flags:
+  - r: "-m.*"
+```
+
 These options can be also passed on the command line, for instance:
 
 ```bash
diff --git a/docs/troubleshooting.md b/docs/troubleshooting.md
index 801798f36..d4bb11085 100644
--- a/docs/troubleshooting.md
+++ b/docs/troubleshooting.md
@@ -271,7 +271,9 @@ If this doesn't help to include paths can be customized using config options:
 * `add_compile_flags` - which adds a list of compile flags such as include paths
   to each entry of the compilation database
 * `remove_compile_flags` - which removes existing compile flags from each entry
-  of the compilation database
+  of the compilation database, it can be provided as a regular string that
+  must match the entire flag or as an object with `r:` key, which can contain
+  a regular expression that will match a set of flags
 
 For instance:
 
@@ -280,6 +282,7 @@ add_compile_flags:
   - -I/opt/my_toolchain/include
 remove_compile_flags:
   - -I/usr/include
+  - r: "-m.*"
 ```
 
 These options can be also passed on the command line, for instance:
diff --git a/src/config/config.h b/src/config/config.h
index 94b9a77ac..67f3dd006 100644
--- a/src/config/config.h
+++ b/src/config/config.h
@@ -759,7 +759,7 @@ struct config : public inheritable_diagram_options {
     /*! List of compilation flags to be removed from the compilation
      * commands from database
      */
-    option<std::vector<std::string>> remove_compile_flags{
+    option<std::vector<common::string_or_regex>> remove_compile_flags{
         "remove_compile_flags"};
 
     /*! Extract include paths by executing specified compiler driver.
diff --git a/src/config/schema.h b/src/config/schema.h
index a90f7cdbd..1f8bb767f 100644
--- a/src/config/schema.h
+++ b/src/config/schema.h
@@ -339,7 +339,7 @@ const std::string schema_str = R"(
     output_directory: !optional string
     query_driver: !optional string
     add_compile_flags: !optional [string]
-    remove_compile_flags: !optional [string]
+    remove_compile_flags: !optional [regex_or_string_t]
     allow_empty_diagrams: !optional bool
     diagram_templates: !optional diagram_templates_t
     diagrams: !required map_t<string;diagram_t>
diff --git a/tests/test_cases.cc b/tests/test_cases.cc
index 16560ef8d..59c5779de 100644
--- a/tests/test_cases.cc
+++ b/tests/test_cases.cc
@@ -44,6 +44,8 @@ std::pair<clanguml::config::config_ptr,
     clanguml::common::compilation_database_ptr>
 load_config(const std::string &test_name)
 {
+    using clanguml::common::string_or_regex;
+
     std::pair<clanguml::config::config_ptr,
         clanguml::common::compilation_database_ptr>
         res;
@@ -69,10 +71,11 @@ load_config(const std::string &test_name)
     LOG_DBG("Loading compilation database from {}",
         res.first->compilation_database_dir());
 
-    std::vector<std::string> remove_compile_flags{
-        std::string{"-Wno-class-memaccess"},
-        std::string{"-forward-unknown-to-host-compiler"},
-        std::string{"--generate-code=arch=compute_75,code=[compute_75,sm_75]"}};
+    std::vector<string_or_regex> remove_compile_flags{
+        string_or_regex{"-Wno-class-memaccess"},
+        string_or_regex{"-forward-unknown-to-host-compiler"},
+        string_or_regex{
+            std::regex{"--generate-code=.*"}, "--generate-code=.*"}};
 
     res.first->remove_compile_flags.set(remove_compile_flags);
 
diff --git a/tests/test_config.cc b/tests/test_config.cc
index 1c0d073d6..5b5132cee 100644
--- a/tests/test_config.cc
+++ b/tests/test_config.cc
@@ -242,6 +242,18 @@ TEST_CASE("Test config layout")
         clanguml::common::model::diagram_t::kPackage);
 }
 
+TEST_CASE("Test add and remove compile flags options")
+{
+    auto cfg = clanguml::config::load("./test_config_data/complete.yml");
+
+    REQUIRE(cfg.add_compile_flags().size() == 1);
+    REQUIRE(cfg.add_compile_flags()[0] == "-fparse-all-comments");
+    REQUIRE(cfg.remove_compile_flags().size() == 2);
+    REQUIRE(cfg.remove_compile_flags()[0] == "-Werror");
+    REQUIRE_FALSE(cfg.remove_compile_flags()[1] == "-Wwarning");
+    REQUIRE(cfg.remove_compile_flags()[1] == "-march=amd64");
+}
+
 TEST_CASE("Test config emitters")
 {
     auto cfg = clanguml::config::load("./test_config_data/complete.yml");
diff --git a/tests/test_config_data/complete.yml b/tests/test_config_data/complete.yml
index 727e103ac..b0a96a229 100644
--- a/tests/test_config_data/complete.yml
+++ b/tests/test_config_data/complete.yml
@@ -12,6 +12,11 @@ generate_links:
   link: "https://github.com/bkryza/clang-uml/blob/{{ git.commit }}/{{ element.source.path }}#L{{ element.source.line }}"
   # Tooltip pattern
   tooltip: "{{ element.name }}"
+add_compile_flags:
+  - -fparse-all-comments
+remove_compile_flags:
+  - -Werror
+  - r: "-m.*"
 # The map of diagrams - keys are also diagram file names
 diagrams:
   config_class: