diff --git a/.changes/next-release/feature-NettyNIOHTTPClient-8f8589d.json b/.changes/next-release/feature-NettyNIOHTTPClient-8f8589d.json
new file mode 100644
index 00000000000..6feae101e27
--- /dev/null
+++ b/.changes/next-release/feature-NettyNIOHTTPClient-8f8589d.json
@@ -0,0 +1,6 @@
+{
+    "type": "feature",
+    "category": "Netty NIO HTTP Client",
+    "contributor": "",
+    "description": "Fallback to prior knowledge if default client setting is ALPN and request has HTTP endpoint"
+}
diff --git a/http-clients/netty-nio-client/src/main/java/software/amazon/awssdk/http/nio/netty/NettyNioAsyncHttpClient.java b/http-clients/netty-nio-client/src/main/java/software/amazon/awssdk/http/nio/netty/NettyNioAsyncHttpClient.java
index db973050326..8c37f0db3cc 100644
--- a/http-clients/netty-nio-client/src/main/java/software/amazon/awssdk/http/nio/netty/NettyNioAsyncHttpClient.java
+++ b/http-clients/netty-nio-client/src/main/java/software/amazon/awssdk/http/nio/netty/NettyNioAsyncHttpClient.java
@@ -140,10 +140,6 @@ private void failIfAlpnUsedWithHttp(AsyncExecuteRequest request) {
             if (isAlpnUserConfigured) {
                 throw new UnsupportedOperationException("ALPN can only be used with HTTPS, not HTTP.");
             }
-            if (protocolNegotiation == ProtocolNegotiation.ALPN) {
-                log.debug(null, () -> "Default client protocol negotiation is ALPN, but request endpoint is HTTP. Prior "
-                                      + "knowledge negotiation will be used instead");
-            }
         }
     }