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# elgm-inf
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# naomi-aghq
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Code for the manuscript Howes, Stringer, Flaxman and Eaton "Fast approximate Bayesian inference of HIV indicators using the Naomi small-area estimation model" (in preparation).
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Code for the manuscript Howes, Stringer, Flaxman and Eaton "Fast approximate Bayesian inference of HIV indicators using PCA adaptive Gauss-Hermite quadrature" (in preparation).
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[Naomi](https://github.com/mrc-ide/naomi) ([Eaton et al, 2021](https://onlinelibrary.wiley.com/doi/10.1002/jia2.25788)) is a spatial evidence synthesis model used to produce district-level HIV epidemic indicators in sub-Saharan Africa.
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Multiple outcomes of interest, including HIV prevalence, HIV incidence and treatment coverage are jointly modelled using both household survey data and routinely reported health system data.
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The model is provided as a [tool](https://naomi.unaids.org/) for countries to input their data to and generate estimates during a yearly process supported by UNAIDS.
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Currently, inference is conducted using empirical Bayes and a Gaussian approximation via the [`TMB`](https://kaskr.github.io/adcomp/_book/Introduction.html) R package.
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We propose a new inference method which extends adaptive Gauss-Hermite quadrature to deal with >20 hyperparameters, enabling fast and accurate inference for Naomi and other [extended latent Gaussian](https://www.tandfonline.com/doi/full/10.1080/10618600.2022.2099403) models.
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We propose a new inference method extending adaptive Gauss-Hermite quadrature to deal with >20 hyperparameters, enabling fast and accurate inference for Naomi and other [extended latent Gaussian](https://www.tandfonline.com/doi/full/10.1080/10618600.2022.2099403) models.
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Using data from Malawi, our method improves the accuracy of inferences across a range of metrics, while being substantially faster to run than Hamiltonian Monte Carlo with the No-U-Turn sampler.
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By extending the [`aghq`](https://github.com/awstringer1/aghq) package ([Stringer, 2021](https://arxiv.org/abs/2101.04468)) we facilitate easy, flexible use of our method when provided a [`TMB`](https://kaskr.github.io/adcomp/_book/Introduction.html) C++ template for the model's log-posterior.
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Our implementation uses the [`aghq`](https://github.com/awstringer1/aghq) package ([Stringer, 2021](https://arxiv.org/abs/2101.04468)) facilitating easy, flexible use of the method when provided a [`TMB`](https://kaskr.github.io/adcomp/_book/Introduction.html) C++ template for the model's log-posterior.
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