diff --git a/superset-frontend/packages/superset-ui-core/src/query/types/Operator.ts b/superset-frontend/packages/superset-ui-core/src/query/types/Operator.ts
index 5b598312c0bce..0d2cb5b59ba7f 100644
--- a/superset-frontend/packages/superset-ui-core/src/query/types/Operator.ts
+++ b/superset-frontend/packages/superset-ui-core/src/query/types/Operator.ts
@@ -30,6 +30,7 @@ const BINARY_OPERATORS = [
   '<=',
   'ILIKE',
   'LIKE',
+  'NOT LIKE',
   'REGEX',
   'TEMPORAL_RANGE',
 ] as const;
diff --git a/superset/models/helpers.py b/superset/models/helpers.py
index b841426ff7172..1c6ad2f5d3bb0 100644
--- a/superset/models/helpers.py
+++ b/superset/models/helpers.py
@@ -1909,6 +1909,11 @@ def get_sqla_query(  # pylint: disable=too-many-arguments,too-many-locals,too-ma
                             where_clause_and.append(sqla_col.like(eq))
                         else:
                             where_clause_and.append(sqla_col.ilike(eq))
+                    elif op in {utils.FilterOperator.NOT_LIKE.value}:
+                        if target_generic_type != GenericDataType.STRING:
+                            sqla_col = sa.cast(sqla_col, sa.String)
+
+                        where_clause_and.append(sqla_col.not_like(eq))
                     elif (
                         op == utils.FilterOperator.TEMPORAL_RANGE.value
                         and isinstance(eq, str)
diff --git a/superset/utils/core.py b/superset/utils/core.py
index ee5e451f3eb76..d01dd517efbac 100644
--- a/superset/utils/core.py
+++ b/superset/utils/core.py
@@ -217,6 +217,7 @@ class FilterOperator(StrEnum):
     GREATER_THAN_OR_EQUALS = ">="
     LESS_THAN_OR_EQUALS = "<="
     LIKE = "LIKE"
+    NOT_LIKE = "NOT LIKE"
     ILIKE = "ILIKE"
     IS_NULL = "IS NULL"
     IS_NOT_NULL = "IS NOT NULL"