diff --git a/src/material/autocomplete/autocomplete-trigger.ts b/src/material/autocomplete/autocomplete-trigger.ts
index 1bc33c6b512c..3852150c44c3 100644
--- a/src/material/autocomplete/autocomplete-trigger.ts
+++ b/src/material/autocomplete/autocomplete-trigger.ts
@@ -8,6 +8,7 @@
 
 import {addAriaReferencedId, removeAriaReferencedId} from '@angular/cdk/a11y';
 import {
+  afterNextRender,
   AfterViewInit,
   booleanAttribute,
   ChangeDetectorRef,
@@ -18,6 +19,7 @@ import {
   inject,
   Inject,
   InjectionToken,
+  Injector,
   Input,
   NgZone,
   OnChanges,
@@ -227,6 +229,10 @@ export class MatAutocompleteTrigger
   @Input({alias: 'matAutocompleteDisabled', transform: booleanAttribute})
   autocompleteDisabled: boolean;
 
+  private _initialized = new Subject();
+
+  private _injector = inject(Injector);
+
   constructor(
     private _element: ElementRef<HTMLInputElement>,
     private _overlay: Overlay,
@@ -249,6 +255,9 @@ export class MatAutocompleteTrigger
   private _aboveClass = 'mat-mdc-autocomplete-panel-above';
 
   ngAfterViewInit() {
+    this._initialized.next();
+    this._initialized.complete();
+
     const window = this._getWindow();
 
     if (typeof window !== 'undefined') {
@@ -301,12 +310,7 @@ export class MatAutocompleteTrigger
 
     if (this.panelOpen) {
       // Only emit if the panel was visible.
-      // The `NgZone.onStable` always emits outside of the Angular zone,
-      // so all the subscriptions from `_subscribeToClosingActions()` are also outside of the Angular zone.
-      // We should manually run in Angular zone to update UI after panel closing.
-      this._zone.run(() => {
-        this.autocomplete.closed.emit();
-      });
+      this.autocomplete.closed.emit();
     }
 
     this.autocomplete._isOpen = this._overlayAttached = false;
@@ -378,10 +382,7 @@ export class MatAutocompleteTrigger
 
     // If there are any subscribers before `ngAfterViewInit`, the `autocomplete` will be undefined.
     // Return a stream that we'll replace with the real one once everything is in place.
-    return this._zone.onStable.pipe(
-      take(1),
-      switchMap(() => this.optionSelections),
-    );
+    return this._initialized.pipe(switchMap(() => this.optionSelections));
   }) as Observable<MatOptionSelectionChange>;
 
   /** The currently active option, coerced to MatOption type. */
@@ -592,7 +593,14 @@ export class MatAutocompleteTrigger
    * stream every time the option list changes.
    */
   private _subscribeToClosingActions(): Subscription {
-    const firstStable = this._zone.onStable.pipe(take(1));
+    const initialRender = new Observable(subscriber => {
+      afterNextRender(
+        () => {
+          subscriber.next();
+        },
+        {injector: this._injector},
+      );
+    });
     const optionChanges = this.autocomplete.options.changes.pipe(
       tap(() => this._positionStrategy.reapplyLastPosition()),
       // Defer emitting to the stream until the next tick, because changing
@@ -600,41 +608,36 @@ export class MatAutocompleteTrigger
       delay(0),
     );
 
-    // When the zone is stable initially, and when the option list changes...
+    // When the options are initially rendered, and when the option list changes...
     return (
-      merge(firstStable, optionChanges)
+      merge(initialRender, optionChanges)
         .pipe(
           // create a new stream of panelClosingActions, replacing any previous streams
           // that were created, and flatten it so our stream only emits closing events...
           switchMap(() => {
-            // The `NgZone.onStable` always emits outside of the Angular zone, thus we have to re-enter
-            // the Angular zone. This will lead to change detection being called outside of the Angular
-            // zone and the `autocomplete.opened` will also emit outside of the Angular.
-            this._zone.run(() => {
-              const wasOpen = this.panelOpen;
-              this._resetActiveItem();
-              this._updatePanelState();
-              this._changeDetectorRef.detectChanges();
-
+            const wasOpen = this.panelOpen;
+            this._resetActiveItem();
+            this._updatePanelState();
+            this._changeDetectorRef.detectChanges();
+
+            if (this.panelOpen) {
+              this._overlayRef!.updatePosition();
+            }
+
+            if (wasOpen !== this.panelOpen) {
+              // If the `panelOpen` state changed, we need to make sure to emit the `opened` or
+              // `closed` event, because we may not have emitted it. This can happen
+              // - if the users opens the panel and there are no options, but the
+              //   options come in slightly later or as a result of the value changing,
+              // - if the panel is closed after the user entered a string that did not match any
+              //   of the available options,
+              // - if a valid string is entered after an invalid one.
               if (this.panelOpen) {
-                this._overlayRef!.updatePosition();
-              }
-
-              if (wasOpen !== this.panelOpen) {
-                // If the `panelOpen` state changed, we need to make sure to emit the `opened` or
-                // `closed` event, because we may not have emitted it. This can happen
-                // - if the users opens the panel and there are no options, but the
-                //   options come in slightly later or as a result of the value changing,
-                // - if the panel is closed after the user entered a string that did not match any
-                //   of the available options,
-                // - if a valid string is entered after an invalid one.
-                if (this.panelOpen) {
-                  this._emitOpened();
-                } else {
-                  this.autocomplete.closed.emit();
-                }
+                this._emitOpened();
+              } else {
+                this.autocomplete.closed.emit();
               }
-            });
+            }
 
             return this.panelClosingActions;
           }),