diff --git a/test/client/client_tests.conf b/test/client/client_tests.conf
new file mode 100644
index 00000000..b0a4ede9
--- /dev/null
+++ b/test/client/client_tests.conf
@@ -0,0 +1,22 @@
+# Example configuration for client tests.
+# Adapt these settings to your local engine setup and then run:
+#   tox -e client
+# This configuration can be copied to a different location and used as
+#   CLIENT_TEST_CONF=/path/to/test.conf tox -e client
+
+# Common parameters must be all kept, and are used by all tests
+common:
+    engine_url: https://engine.com
+    username: admin@internal
+    password: password
+    cafile: /path/to/cert.pem
+
+tests:
+    # Image upload and download test. Different formats are tested.
+    # Image and disk contents are compared.
+    upload-download:
+        # Set local storage domain names to test.
+        # At least one block and one file storage domain shall be tested.
+        storage-domains:
+            - nfs1
+            - scsi1
diff --git a/test/client/conftest.py b/test/client/conftest.py
new file mode 100644
index 00000000..4fc57b14
--- /dev/null
+++ b/test/client/conftest.py
@@ -0,0 +1,35 @@
+# ovirt-imageio
+# Copyright (C) 2022 Red Hat, Inc.
+#
+# This program is free software; you can redistribute it and/or modify
+# it under the terms of the GNU General Public License as published by
+# the Free Software Foundation; either version 2 of the License, or
+# (at your option) any later version.
+
+import logging
+import os
+import yaml
+
+import pytest
+
+
+log = logging.getLogger("test")
+
+
+@pytest.fixture
+def config(tmpdir):
+    with open(os.environ['CLIENT_TEST_CONF'], encoding='utf-8') as fstream:
+        try:
+            conf = yaml.safe_load(fstream)
+        except yaml.YAMLError as exc:
+            log.error("Invalid YAML format: %s", exc)
+            raise
+
+    conf_file = os.path.join(tmpdir, 'ovirt-img.conf')
+    os.environ['XDG_CONFIG_HOME'] = str(tmpdir)
+    with open(conf_file, "w+", encoding="utf-8") as fstream:
+        fstream.write("[test]\n")
+        for k, v in conf["common"].items():
+            fstream.write(f"{k} = {v}\n")
+
+    yield conf
diff --git a/test/client/upload_download_test.py b/test/client/upload_download_test.py
new file mode 100644
index 00000000..e1bfbf5d
--- /dev/null
+++ b/test/client/upload_download_test.py
@@ -0,0 +1,103 @@
+# ovirt-imageio
+# Copyright (C) 2022 Red Hat, Inc.
+#
+# This program is free software; you can redistribute it and/or modify
+# it under the terms of the GNU General Public License as published by
+# the Free Software Foundation; either version 2 of the License, or
+# (at your option) any later version.
+
+import contextlib
+import logging
+import os
+import uuid
+import subprocess
+import sys
+
+import pytest
+import ovirtsdk4 as sdk
+
+from ovirt_imageio._internal import qemu_img
+
+
+OS_VERSION = 'fedora-36'
+
+log = logging.getLogger("test")
+
+
+class ClientError(Exception):
+    pass
+
+
+def create_disk(path, fmt, os_version=OS_VERSION):
+    env = os.environ.copy()
+    env['LIBGUESTFS_BACKEND'] = 'direct'
+    cmd = ['virt-builder', os_version, '--format', fmt, '-o', path]
+    subprocess.check_call(cmd, env=env)
+
+
+def run_upload_disk(storage_domain, image, disk_id=None, log_level=None):
+    # Make sure it runs with the same tox environment executable
+    cmd = [sys.executable, './ovirt-img', 'upload-disk', '-c', 'test']
+    cmd.extend(['-s', storage_domain])
+    if log_level:
+        cmd.extend(['--log-level', log_level])
+    if disk_id:
+        cmd.extend(['--disk-id', disk_id])
+    cmd.append(image)
+    try:
+        subprocess.run(cmd, check=True)
+    except subprocess.CalledProcessError as exc:
+        raise ClientError(f'Client Error: {exc}') from exc
+
+
+def run_download_disk(disk_id, image, log_level=None):
+    # Make sure it runs with the same tox environment executable
+    cmd = [sys.executable, './ovirt-img', 'download-disk', '-c', 'test']
+    if log_level:
+        cmd.extend(['--log-level', log_level])
+    cmd.extend([disk_id, image])
+    try:
+        subprocess.run(cmd, check=True)
+    except subprocess.CalledProcessError as exc:
+        raise ClientError(f'Client Error: {exc}') from exc
+
+
+def remove_disk(conf, sd_name, disk_id):
+    connection = sdk.Connection(
+        url=f'{conf["engine_url"]}/ovirt-engine/api',
+        username=conf["username"],
+        password=conf["password"],
+        ca_file=conf["cafile"]
+    )
+    with contextlib.closing(connection):
+        sd_service = connection.system_service().storage_domains_service()
+        found_sd = sd_service.list(search=f'name={sd_name}')
+        if not found_sd:
+            raise RuntimeError(f"Couldn't find storage domain {sd_name}")
+
+        sd = found_sd[0]
+        sd_service = sd_service.storage_domain_service(sd.id)
+        sd_service.disks_service().disk_service(disk_id).remove()
+
+
+@pytest.mark.parametrize("fmt", ["raw", "qcow2"])
+def test_upload_download(config, tmpdir, fmt):
+    image = os.path.join(tmpdir, f'image.{fmt}')
+    create_disk(image, fmt)
+    test_config = config["tests"]["upload-download"]
+    for sd_name in test_config.get("storage-domains", []):
+        disk_id = str(uuid.uuid4())
+        try:
+            log.info("Upload %s image to SD %s", fmt, sd_name)
+            run_upload_disk(sd_name, image, disk_id)
+            down_img = os.path.join(tmpdir, f'downloaded.{fmt}')
+            log.info("Download image %s", disk_id)
+            run_download_disk(disk_id, down_img)
+            log.info("Comparing images")
+            qemu_img.compare(image, down_img)
+        except ClientError as exc:
+            log.error("%s", exc)
+            # Skip disk cleanup if client failed
+            return
+        finally:
+            remove_disk(config["common"], sd_name, disk_id)
diff --git a/tox.ini b/tox.ini
index ece71b38..e20098aa 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,7 +4,7 @@
 # and then run "tox" from this directory.
 
 [tox]
-envlist = flake8,test-{py36,py38,py39,py310},bench-{py36,py38,py39,py310}
+envlist = flake8,test-{py36,py38,py39,py310},bench-{py36,py38,py39,py310},client
 skip_missing_interpreters = True
 whitelist_externals =
     ip
@@ -25,8 +25,19 @@ commands_pre =
     /usr/bin/python3 setup.py build_ext --build-lib .
     python -c 'from test import testutil; print("ipv6 supported: %s" % testutil.ipv6_enabled())'
 commands =
-    test: pytest -m 'not benchmark' --cov=ovirt_imageio --durations=10 {posargs}
-    bench: pytest -m 'benchmark' -vs {posargs}
+    test: pytest -m 'not benchmark' --ignore=test/client --cov=ovirt_imageio --durations=10 {posargs}
+    bench: pytest -m 'benchmark' -vs --ignore=test/client {posargs}
+
+[testenv:client]
+setenv =
+    CLIENT_TEST_CONF = {env:CLIENT_TEST_CONF:{toxinidir}/test/client/client_tests.conf}
+deps =
+    pytest
+    pytest-timeout
+    pyyaml
+    ovirt-engine-sdk-python
+commands =
+    pytest -vs --timeout 200 {posargs} test/client
 
 [testenv:flake8]
 sitepackages = False