iEde2091_BIGG.txt

#exchange reactions
R001ex	1 h2o[e] <->
R002ex	1 pi[e] <-
R003ex	1 sucr[e] <-
R004ex	1 nh4[e] <-
R005ex	1 so4[e] <-
R006ex	1 h[e] <->
R007ex	1 co2[e] ->
R008ex	1 o2[e] <-
R009ex	1 etoh[e] <->
R010ex	1 ac[e] <-
R011ex	1 glc__D[e] <-
R012ex	1 urate[e] ->
#synthesis of biomass components
protein_syn	0.14613 asp__L[c] + 0.15371 glu__L[c] + 0.22294 ala__L[c] + 0.17484 gly[c] + 0.10126 gln__L[c] + 0.08887 asn__L[c] + 0.15713 pro__L[c] + 0.03297 cys__L[c] + 0.16063 arg__L[c] + 0.05566 met__L[c] + 0.2067 ser__L[c] + 0.03822 trp__L[c] + 0.15021 thr__L[c] + 0.06317 his__L[c] + 0.09533 phe__L[c] + 0.07351 tyr__L[c] + 0.16131 val__L[c] + 0.23243 leu__L[c] + 0.12286 ile__L[c] + 0.1126 lys__L[c] -> 1 C00017[c]
lipid_syn	0.147601 hdca[im] + 0.173432 ocdca[im] + 0.01476 arach[im] + 0.369004 ocdcea[im] + 0.295203 lnlc[im] -> 1 C01356[im]
cell_syn	 0.02795 C00075[c] + 0.03051 C00044[c] + 0.0015 C00182[c] + 0.076 C00116[c] + 0.06168 C00422[c] + 0.03399 C00350[c] + 0.01378 C02737[c] + 0.02091 C00063[c] + 0.03153 C01356[c] + 2.55048 C00017[c] + 0.00431 C00286[c] + 0.00398 C00131[c] + 0.00431 C00458[c] + 0.00398 C00459[c] -> 1 cell[c]
cell_wall_syn	73.7 C00965[e] + 2.9 C01356[e] + 1.9 C17937DHN[e] + 1.9 C17937Eu[e] + 1.9 C17937Pyo[e] + 8.3 C00017[e] + 3.2 acgam[e] + 1.1 chtn[e] -> 1 cell_wall[e]
carotenoidDep	0.00521539 caro[c] + 0.028172568 C19892[c] + 0.036692575 C08607[c] -> 1 carotenoids[c]
biomass_wt_37	71.4 h2o[c] + 71.4 atp[c] + 0.014431814 cell_wall[e] + 0.107001573 cell[c] + 0.070023849 carotenoids[c] -> 71.4 h[c] + 71.4 pi[c] + 71.4 adp[c] + 1 biomass
biomass_si	1 biomass ->
ATPM	1 atp[c] + 1 h2o[c] -> 1 adp[c] + 1 pi[c]
#Terpeniod backbone synthesis pathway
R01978[c]	1 C00356[c] + 1 coa[c] <- 1 accoa[c] + 1 h2o[c] + 1 aacoa[c]
GGPS_11	1 frdp[c] + 1 ipdp[c] -> 1 ppi[c] + 1 ggdp[c]
DPMVD1	1 atp[c] + 1 5dpmev[c] -> 1 adp[c] + 1 pi[c] + 1 ipdp[c] + 1 co2[c]
R02082[c]	1 mev__R[c] + 1 coa[c] + 2 nadp[c] <-> 1 C00356[c] + 2 nadph[c] + 2 h[c]
MEVK1x1	1 atp[c] + 1 mev__R[c] <-> 1 adp[c] + 1 5pmev[c]
PMEVK1	1 atp[c] + 1 5pmev[c] <-> 1 adp[c] + 1 5dpmev[c]
R04496[c]	1 amet[c] + 1 C04506[c] <-> 1 ahcys[c] + 1 C04748[c]
R05556[c]	1 frdp[c] + 1 ipdp[c] <-> 1 C05859[c] + 1 ppi[c]
R06447[c]	1 frdp[c] + 8 ipdp[c] <-> 1 dtpcudcpp[c] + 8 ppi[c]
R09847[c]	1 C04748[c] <-> 1 C19691[c]
R09562[c]	1 C19691[c] + 1 o2[c] + 1 h2o[c] <-> 1 C03461[c] + 1 cys__L[c] + 1 h2o2[c]
R09845[c]	1 C20120[c] + 1 h2o[c] <-> 1 C04506[c] + 1 pepd[c]
R09844[c]	1 frdp[c] + 1 cys__L[c] <-> 1 C20120[c] + 1 ppi[c]
#carotenoid synthesis pathway
PHYTES1	2 ggdp[c] -> 1 ppi[c] + 1 prephytedp[c]
R04218[c]	1 prephytedp[c] -> 1 ppi[c] + 1 C05421[c]
R09692[c]	1 C05421[c] + 2 nadp[c] -> 1 C05414[c] + 2 nadph[c] + 2 h[c]
R04787[c]	1 C05414[c] + 2 nadp[c] -> 1 zcarote[c] + 2 nadph[c] + 2 h[c]
R04798[c]	1 zcarote[c] + 2 nadph[c] + 1 o2[c] + 2 h[c] -> 1 neuspn[c] + 2 h2o[c] + 2 nadp[c]
R04800[c]	1 neuspn[c] + 2 nadph[c] + 1 o2[c] + 2 h[c] -> 1 lycop[c] + 2 nadp[c] + 2 h2o[c]
LYCOPC1	1 lycop[c] -> 1 gcarote[c]
GCATENEC1	1 gcarote[c] -> 1 caro[c]
R07518[c]	1 lycop[c] + 2 nadp[c] + 1 o2[c] -> 1 C15867[c] + 2 nadph[c] + 1 h2o[c] + 2 h[c]
R10508[c]	1 C15867[c] -> 1 C08613[c]
R09782[c]	1 C08613[c] + 1 o2[c] -> 1 C19892[c] + 1 C07330[c]
R09783[c]	1 C19892[c] + 1 nad[c] + 1 h2o[c] -> 1 C08607[c] + 1 nadh[c] + 1 h[c]
#DHN melanin synthesis pathway
R10965[c]	5 malcoa[c] <-> 1 C04033[c] + 5 coa[c] + 5 co2[c] + 1 h2o[c]
R02906[c]	1 C00779[c] + 1 nadp[c] <- 1 C04033[c] + 1 nadph[c] + 1 h[c]
R02907[c]	1 C00779[c] -> 1 C01173[c] + 1 h2o[c]
R03322[c]	1 C01624[c] + 1 nadp[c] <- 1 C01173[c] + 1 nadph[c] + 1 h[c]
R900[c]	1 C01624[c] + 1 h[c] -> 1 h2o[c] + 1 X00001[c]
R901[e]	1 X00001[e] -> 1 h2o[e] + 1 C17937DHN[e]
#Lysine degredation pathway
BBHOX1	1 gbbtn[c] + 1 akg[c] + 1 o2[c] <-> 1 C00487[c] + 1 succ[c] + 1 co2[c]
R03451[c]	1 h[c] + 1 tmlys[c] + 1 akg[c] + 1 o2[c] <-> 1 C01259[c] + 1 succ[c] + 1 co2[c]
R03875[c]	1 pcollglys[c] + 1 amet[c] <-> 1 C05544[c] + 1 ahcys[c]
R04866[c]	1 amet[c] + 1 C05544[c] <-> 1 ahcys[c] + 1 C05545[c]
R04867[c]	1 h[c] + 1 amet[c] + 1 C05545[c] <-> 1 ahcys[c] + 1 C05546[c]
SACCD21	1 saccrp__L[c] + 1 nad[c] + 1 h2o[c] <-> 1 lys__L[c] + 1 akg[c] + 1 nadh[c] + 1 h[c]
SACCD11	1 saccrp__L[c] + 1 nadp[c] + 1 h2o[c] <-> 1 glu__L[c] + 1 L2aadp6sa[c] + 1 nadph[c] + 1 h[c]
AASAD3m1	1 L2aadp6sa[c] + 1 nad[c] + 1 h2o[c] -> 1 L2aadp[c] + 1 nadh[c] + 1 h[c]
AATA1	1 L2aadp[c] + 1 akg[c] <-> 1 2oxoadp[c] + 1 glu__L[c]
R01940[c]	1 2oxoadp[c] + 1 C15972[c] -> 1 S_gtrdhdlp[c] + 1 co2[c]
R02571[c]	1 glutcoa[c] + 1 C15973[c] <-> 1 coa[c] + 1 S_gtrdhdlp[c]
R02488[c]	1 glutcoa[c] + 1 C04253[c] -> 1 b2coa[c] + 1 C04570[c] + 1 co2[c]
ECOAH11	1 3hbcoa[c] <- 1 b2coa[c] + 1 h2o[c]
HACD1i1	1 3hbcoa[c] + 1 nad[c] <-> 1 aacoa[c] + 1 nadh[c] + 1 h[c]
ACACT1x1	1 coa[c] + 1 aacoa[c] -> 2 accoa[c]
#Glycolysis pathway
R00959[c]	1 g1p[c] <-> 1 g6p_A[c]
R01786[c]	1 atp[c] + 1 glc__aD[c] -> 1 adp[c] + 1 g6p_A[c]
R02740[c]	1 g6p_A[c] <-> 1 f6p_B[c]
R04779[c]	1 atp[c] + 1 f6p_B[c] -> 1 adp[c] + 1 fdp_B[c]
R04780[c]	1 fdp_B[c] + 1 h2o[c] -> 1 f6p_B[c] + 1 pi[c]
R01070[c]	1 fdp_B[c] <-> 1 dhap[c] + 1 g3p[c]
TPI1	1 g3p[c] <-> 1 dhap[c]
GAPDHf1	1 g3p[c] + 1 pi[c] + 1 nad[c] <-> 1 13dpg[c] + 1 nadh[c] + 1 h[c]
PGKm1	1 atp[c] + 1 3pg[c] <-> 1 adp[c] + 1 13dpg[c]
PGM1	1 2pg[c] <-> 1 3pg[c]
PPCK1	1 atp[c] + 1 oaa[c] -> 1 adp[c] + 1 pep[c] + 1 co2[c]
ENOm1	1 2pg[c] <-> 1 pep[c] + 1 h2o[c]
PYK1	1 adp[c] + 1 pep[c] -> 1 atp[c] + 1 pyr[c]
PDHam1hi1	1 pyr[c] + 1 thmpp[c] -> 1 2ahethmpp[c] + 1 co2[c]
R03270[c]	1 2ahethmpp[c] + 1 C15972[c] -> 1 C16255[c] + 1 thmpp[c]
R07618[c]	1 C15973[c] + 1 nad[c] <-> 1 C15972[c] + 1 nadh[c] + 1 h[c]
R02569[c]	1 accoa[c] + 1 C15973[c] <-> 1 coa[c] + 1 C16255[c]
PDCh1	1 2ahethmpp[c] -> 1 acald[c] + 1 thmpp[c]
ALCD2x1	1 acald[c] + 1 nadh[c] + 1 h[c] -> 1 etoh[c] + 1 nad[c]
ALDD2x1	1 acald[c] + 1 nad[c] + 1 h2o[c] <-> 1 ac[c] + 1 nadh[c] + 1 h[c]
ACS1	1 atp[c] + 1 ac[c] + 1 coa[c] -> 1 amp[c] + 1 ppi[c] + 1 accoa[c]
#Amino and neucleic acid sugar metabolism
R08193[c]	1 acgam6p[c] <-> 1 C04501[c]
R00416[c]	1 h[c] + 1 C04501[c] + 1 utp[c] -> 1 ppi[c] + 1 uacgam[c]
UAG2EMA1	1 uacgam[c] + 1 h2o[c] -> 1 acmana[c] + 1 udp[c]
ACGAM2E1	1 acmana[c] <-> 1 acgam[c]
R02335[c]	1 uacgam[c] <-> 1 udp[c] + 1 chtn[c]
R00100[c]	1 nadh[c] + 2 ficytb5[c] -> 1 nad[c] + 2 focytb5[c] + 1 h[c]
G6PDA1	1 gam6p[c] + 1 h2o[c] <-> 1 C00085[c] + 1 nh4[c]
R01433[c]	1 xyl__D[c] <-> 1 C02352[c] + 1 h2o[c]
ACGAM6PS1	1 accoa[c] + 1 gam6p[c] <-> 1 coa[c] + 1 acgam6p[c]
AGDC1	1 acgam6p[c] + 1 h2o[c] -> 1 gam6p[c] + 1 ac[c]
R09009[c]	1 udparab[c] <-> 1 C18094[c]
R03078[c]	1 C18094[c] -> 1 C02474[c] + 1 udp[c]
R01762[c]	1 C02474[c] + 1 h2o[c] -> 1 C00259[c]
UDPGALOR1	1 udpgal[c] + 2 nad[c] + 1 h2o[c] -> 1 udpgalur[c] + 2 nadh[c] + 2 h[c]
R02636[c]	1 udpgalur[c] -> 1 udparab[c] + 1 co2[c]
#Unsaturated fatty acid synthesis
R07937[im]	1 C16169[im] + 1 accoa[im] <-> 1 coa[im] + 1 C16376[im]
R11043[im]	1 ocdce9coa[im] + 2 focytb5[im] + 1 o2[im] + 2 h[im] <-> 1 lnlccoa[im] + 2 ficytb5[im] + 2 h2o[im]
R08176[im]	1 ocdce9coa[im] + 1 h2o[im] <-> 1 coa[im] + 1 ocdcea[im]
FACOAE1801	1 strcoa[im] + 1 h2o[im] <-> 1 coa[im] + 1 ocdca[im]
R02224[im]	1 strcoa[im] + 1 malcoa[im] + 2 nadph[im] + 2 h[im] <-> 1 C02041[im] + 1 co2[im] + 2 nadp[im] + 1 coa[im] + 1 h2o[im]
COA1819ZD9DS1	1 od2coa[im] + 1 nadph[im] + 1 h[im] <-> 1 strcoa[im] + 1 nadp[im]
R08175[im]	1 C02041[im] + 1 h2o[im] <-> 1 coa[im] + 1 arach[im]
FACOAE1829Z12Z1	1 lnlccoa[im] + 1 h2o[im] <-> 1 coa[im] + 1 lnlc[im]
R08180[im]	1 C16169[im] + 1 h2o[im] <-> 1 coa[im] + 1 C06429[im]
#Unsaturated fatty acid synthesis
3OACOAS1	1 malcoa[c] + 1 pmtcoa[c] <-> 1 3ohodcoa[c] + 1 coa[c] + 1 co2[c]
RE0581R1	1 3ohodcoa[c] + 1 nadph[c] + 1 h[c] <-> 1 CE2248[c] + 1 nadp[c]
RE0582N1	1 CE2248[c] <-> 1 od2coa[c] + 1 h2o[c]
R07766[c]	1 C05752[c] + 1 C16240[c] -> 1 C16236[c] + 1 ACP[c]
#Triglycerol synthesis
R02687[c]	1 C00641[c] + 1 h2o[c] -> 1 C01885[c] + 1 C00162[c]
R01001[c]	1 cyst__L[c] + 1 h2o[c] -> 1 cys__L[c] + 1 nh4[c] + 1 2obut[c]
R05209[c]	1 dag_hs[c] + 1 h2o[c] <-> 1 C01885[c] + 1 Rtotal[c]
R01369[c]	1 tag_cho[c] + 1 h2o[c] -> 1 h[c] + 1 dag_hs[c] + 1 Rtotal[c]
R02688[c]	1 C00641[c] + 1 h2o[c] <-> 1 C02112[c] + 1 C00162[c]
R02694[c]	1 C00605[c] + 1 C00641[c] <-> 1 coa[c] + 1 tag_cho[c]
R02760[c]	1 C00605[c] + 1 1ag3p_SC[c] <-> 1 coa[c] + 1 pa_EC[c]
R03332[c]	1 pail_cho[c] + 1 h2o[c] <-> 1 mi1p__D[c] + 1 C00641[c]
R03435[c]	1 pail45p_cho[c] + 1 h2o[c] <-> 1 C01245[c] + 1 C00641[c]
R04404[c]	1 pail45p_cho[c] + 1 h2o[c] -> 1 pail4p_cho[c] + 1 pi[c]
R10952[c]	1 pail4p_cho[c] + 1 h2o[c] <-> 1 C01220[c] + 1 C00641[c]
R03394[c]	1 C01245[c] + 1 h2o[c] -> 1 C01220[c] + 1 pi[c]
R05800[c]	1 atp[c] + 1 C01245[c] -> 1 adp[c] + 1 C11555[c]
R05801[c]	1 atp[c] + 1 C11555[c] -> 1 adp[c] + 1 C01284[c]
R10065[c]	2 atp[c] + 1 C01245[c] -> 2 adp[c] + 1 C01284[c]
R01309[c]	1 pchol_cho[c] + 2 h2o[c] + 1 h[c] <-> 1 g3pc[c] + 2 C00162[c]
R07291[c]	1 C04230[c] + 1 h2o[c] <-> 1 g3pc[c] + 1 Rtotal[c]
R02744[c]	1 h[c] + 1 g3pc[c] + 1 Rtotal[c] -> 1 C04233[c] + 1 h2o[c]
#Glycerolipid synthesis
r03931	1 glyald[c] + 1 nad[c] + 1 h2o[c] <-> 1 glyc__R[c] + 1 nadh[c] + 1 h[c]
ALCD19y1	1 glyc[c] + 1 nadp[c] <-> 1 glyald[c] + 1 nadph[c] + 1 h[c]
GLYCDx1	1 glyc[c] + 1 nad[c] <-> 1 dha[c] + 1 nadh[c] + 1 h[c]
DHAK1	1 atp[c] + 1 dha[c] -> 1 adp[c] + 1 dhap[c]
GLYK1	1 atp[c] + 1 glyc[c] -> 1 adp[c] + 1 glyc3p[c]
R09419[c]	1 3oacoa[c] + 1 coa[c] + 1 co2[c] -> 1 malcoa[c] + 1 accoa[c]
R00851[c]	1 glyc3p[c] + 1 accoa[c] -> 1 1ag3p_SC[c] + 1 coa[c]
R02241[c]	1 1ag3p_SC[c] + 1 accoa[c] -> 1 pa_EC[c] + 1 coa[c]
R02239[c]	1 pa_EC[c] + 1 h2o[c] <-> 1 C00641[c] + 1 pi[c]
R05333[c]	1 C00865[c] + 1 C00641[c] <-> 1 C06254[c] + 1 tag_cho[c]
R04470[c]	1 C06037[c] + 1 h2o[c] <-> 1 C03692[c] + 1 gal[c]
R04471[c]	1 C03692[c] + 2 h2o[c] <-> 1 HC01444[c] + 2 C00162[c]
#Glycerophospholipid synthesis
R03756[c]	1 C00605[c] + 1 C01885[c] <-> 1 coa[c] + 1 C00641[c]
R00538[c]	1 C00071[c] + 1 nad[c] + 1 h2o[c] <-> 1 Rtotal[c] + 1 nadh[c] + 1 h[c]
G3PT1	1 glyc3p[c] + 1 h2o[c] -> 1 glyc[c] + 1 pi[c]
G3PDm1	1 glyc3p[c] + 1 fad[c] -> 1 dhap[c] + 1 fadh2[c]
CHOLK1	1 atp[c] + 1 chol[c] -> 1 adp[c] + 1 cholp[c]
R01310[c]	1 pchol_cho[c] + 1 h2o[c] <-> 1 pa_EC[c] + 1 chol[c]
RE3511C1	1 amet[c] + 1 ptd2meeta_SC[c] -> 1 ahcys[c] + 1 pchol_cho[c]
R01799[c]	1 ctp[c] + 1 pa_EC[c] -> 1 ppi[c] + 1 cdpdag_cho[c]
R01801[c]	1 cdpdag_cho[c] + 1 glyc3p[c] <-> 1 cmp[c] + 1 pgp_EC[c]
CDIPTr_cho1	1 cdpdag_cho[c] + 1 inost[c] <-> 1 cmp[c] + 1 pail_cho[c]
CHLPCTD1	1 ctp[c] + 1 cholp[c] <-> 1 h[c] + 1 ppi[c] + 1 cdpchol[c]
R02055[c]	1 ps_cho[c] <-> 1 pe_hs[c] + 1 co2[c]
R02056[c]	1 amet[c] + 1 pe_hs[c] <-> 1 ahcys[c] + 1 C01241[c]
R02746[c]	1 C04230[c] + 1 h2o[c] -> 1 g3pc[c] + 1 C00162[c]
R02747[c]	1 C04233[c] + 1 h2o[c] <-> 1 g3pc[c] + 1 C00162[c]
R02756[c]	1 1ag3p_SC[c] + 1 nadp[c] <-> 1 adhap_hs[c] + 1 nadph[c] + 1 h[c]
R03416[c]	1 C04438[c] + 1 h2o[c] <-> 1 C00162[c] + 1 g3pe[c]
R03417[c]	1 C05973[c] + 1 h2o[c] <-> 1 C00162[c] + 1 g3pe[c]
RE0066C1	1 amet[c] + 1 C01241[c] <-> 1 ahcys[c] + 1 ptd2meeta_SC[c]
#Lysine Biosynthesis
R00271[c]	1 akg[c] + 1 accoa[c] + 1 h2o[c] -> 1 coa[c] + 1 h[c] + 1 C01251[c]
R03444[c]	1 C01251[c] <-> 1 hacon_C[c] + 1 h2o[c]
HACNHm1	1 hicit[c] <-> 1 hacon_C[c] + 1 h2o[c]
R01934[c]	1 hicit[c] + 1 nad[c] <-> 1 2oxoadp[c] + 1 co2[c] + 1 nadh[c] + 1 h[c]
R03098[c]	1 L2aadp[c] + 1 atp[c] <-> 1 C05560[c] + 1 ppi[c]
R04863[c]	1 C05560[c] + 1 C11482[c] -> 1 C05535[c] + 1 amp[c]
R04390[c]	1 C05535[c] + 1 nadph[c] + 1 h[c] -> 1 L2aadp6sa[c] + 1 C11482[c] + 1 nadp[c]
#Valine, Leucine, and Isoleucine biosynthesis
R00226[c]	2 pyr[c] -> 1 alac__S[c] + 1 co2[c]
R00994[c]	1 r3mmal[c] + 1 nad[c] -> 1 2obut[c] + 1 co2[c] + 1 nadh[c] + 1 h[c]
LLEUDr1	1 4mop[c] + 1 nh4[c] + 1 nadh[c] + 1 h[c] -> 1 leu__L[c] + 1 h2o[c] + 1 nad[c]
LEUTAi1	1 4mop[c] + 1 glu__L[c] -> 1 leu__L[c] + 1 akg[c]
IPPS1	1 accoa[c] + 1 3mob[c] + 1 h2o[c] -> 1 3c3hmp[c] + 1 coa[c]
VALTA1	1 val__L[c] + 1 akg[c] <-> 1 3mob[c] + 1 glu__L[c]
OMCDC1	1 4mop[c] + 1 co2[c] -> 1 3c4mop[c]
R02196[c]	1 ile__L[c] + 1 nad[c] + 1 h2o[c] -> 1 3mop[c] + 1 nh4[c] + 1 nadh[c] + 1 h[c]
ILETA1	1 3mop[c] + 1 glu__L[c] -> 1 ile__L[c] + 1 akg[c]
R03896[c]	1 C02612[c] -> 1 citac[c] + 1 h2o[c]
CITCIb1	1 citac[c] + 1 h2o[c] -> 1 r3mmal[c]
IPPMIb1	1 3c3hmp[c] <-> 1 2ippm[c] + 1 h2o[c]
IPPMIa1	1 3c2hmp[c] <-> 1 2ippm[c] + 1 h2o[c]
IPMD1	1 3c2hmp[c] + 1 nad[c] -> 1 3c4mop[c] + 1 nadh[c] + 1 h[c]
R04440[c]	1 23dhmb[c] + 1 nadp[c] <-> 1 3hmoa[c] + 1 nadph[c] + 1 h[c]
R05071[c]	1 alac__S[c] <-> 1 3hmoa[c]
R04441[c]	1 23dhmb[c] -> 1 3mob[c] + 1 h2o[c]
R05068[c]	1 23dhmp[c] + 1 nadp[c] <-> 1 3hmop[c] + 1 nadph[c] + 1 h[c]
R05069[c]	1 2ahbut[c] <-> 1 3hmop[c]
R05070[c]	1 23dhmp[c] -> 1 3mop[c] + 1 h2o[c]
R07399[c]	1 accoa[c] + 1 pyr[c] + 1 h2o[c] -> 1 C02612[c] + 1 coa[c]
R08648[c]	1 pyr[c] + 1 2obut[c] -> 1 2ahbut[c] + 1 co2[c]
#Valine, Leucine, and Isoleucine degredation
AACOAT1	1 atp[c] + 1 acac[c] + 1 coa[c] -> 1 amp[c] + 1 ppi[c] + 1 aacoa[c]
R01360[c]	1 C00356[c] -> 1 accoa[c] + 1 acac[c]
R02085[c]	1 C00356[c] <-> 1 3mgcoa[c] + 1 h2o[c]
ECH_3hivcoa1	1 3hivcoa[c] <-> 1 3mb2coa[c] + 1 h2o[c]
ECOAH9m1	1 3hmbcoa[c] <-> 1 2mb2coa[c] + 1 h2o[c]
ECOAH12m1	1 2mp2coa[c] + 1 h2o[c] <-> 1 3hibutcoa[c]
R05064[c]	1 3hibutcoa[c] + 1 h2o[c] <-> 1 coa[c] + 1 3hib[c]
R05066[c]	1 3hib[c] + 1 nad[c] <-> 1 mmtsa[c] + 1 nadh[c] + 1 h[c]
OCOAT11	1 succoa[c] + 1 acac[c] -> 1 succ[c] + 1 aacoa[c]
MACCOAT1	1 coa[c] + 1 2maacoa[c] -> 1 ppcoa[c] + 1 accoa[c]
#Cysteine methionine metabolism
CYSLYSL1	1 cysi__L[c] + 1 h2o[c] <-> 1 pyr[c] + 1 nh4[c] + 1 thcys[c]
R10991[c]	1 C02356[c] + 1 akg[c] -> 1 2obut[c] + 1 glu__L[c]
R10992[c]	1 ala__L[c] + 1 2obut[c] <-> 1 pyr[c] + 1 C02356[c]
CYSDS1	1 cys__L[c] + 1 h2o[c] -> 1 h2s[c] + 1 pyr[c] + 1 nh4[c]
METAT1	1 atp[c] + 1 met__L[c] + 1 h2o[c] -> 1 pi[c] + 1 ppi[c] + 1 amet[c]
CYSO1	1 cys__L[c] + 1 o2[c] -> 1 3sala[c]
R01286[c]	1 cyst__L[c] + 1 h2o[c] -> 1 hcys__L[c] + 1 nh4[c] + 1 pyr[c]
MTAP1	1 5mta[c] + 1 pi[c] -> 1 ade[c] + 1 5mdr1p[c]
HSERTA1	1 accoa[c] + 1 hom__L[c] -> 1 coa[c] + 1 achms[c]
R02619[c]	1 3sala[c] + 1 akg[c] <-> 1 C05527[c] + 1 glu__L[c]
R04861[c]	1 C05527[c] + 1 h2o[c] <-> 1 so3[c] + 1 pyr[c]
R03217[c]	1 achms[c] + 1 cys__L[c] -> 1 cyst__L[c] + 1 ac[c]
R03260[c]	1 suchms[c] + 1 cys__L[c] -> 1 cyst__L[c] + 1 succ[c]
MHPGLUT1	1 mhpglu[c] + 1 hcys__L[c] -> 1 hpglu[c] + 1 met__L[c]
MTRI1	1 5mdr1p[c] -> 1 5mdru1p[c]
ARD_11	1 dhmtp[c] + 1 o2[c] -> 1 2kmb[c] + 1 for[c]
ENOPH1	1 dkmpp[c] + 1 h2o[c] -> 1 dhmtp[c] + 1 pi[c]
MDRPD1	1 5mdru1p[c] -> 1 dkmpp[c] + 1 h2o[c]
ARAT1	1 2kmb[c] + 1 glu__L[c] -> 1 met__L[c] + 1 akg[c]
CYSS_21	1 acser[c] + 1 h2s[c] -> 1 cys__L[c] + 1 ac[c]
SERAT1	1 ser__L[c] + 1 accoa[c] <-> 1 acser[c] + 1 coa[c]
#Selenocompound metabolism
R03599[c]	1 selcys[c] + 1 nad[c] <-> 1 seln[c] + 1 ala__L[c] + 1 nadh[c]
R04929[c]	1 atp[c] + 1 sel[c] <-> 1 ppi[c] + 1 C05686[c]
SELCYSTL1	1 selcyst[c] + 1 h2o[c] -> 1 selhcys[c] + 1 nh4[c] + 1 pyr[c]
R04944[c]	1 C05702[c] + 1 selcys[c] <-> 1 selcyst[c] + 1 pi[c]
R04946[c]	1 suchms[c] + 1 selcys[c] -> 1 selcyst[c] + 1 succ[c]
R09365[c]	1 selhcys[c] + 1 mhpglu[c] -> 1 selmeth[c] + 1 hpglu[c]
R04931[c]	1 selcys[c] + 1 amet[c] <-> 1 C05689[c] + 1 ahcys[c]
R04929[im]	1 atp[im] + 1 sel[im] <-> 1 ppi[im] + 1 C05686[im]
R04770[im]	1 selmeth[im] + 1 h2o[im] <-> 1 C05703[im] + 1 nh4[im] + 1 2obut[im]
R09366[im]	1 C05689[im] + 1 h2o[im] <-> 1 pyr[im] + 1 nh4[im] + 1 C05703[im]
R03596[im]	1 seln[im] + 3 nadp[im] + 3 h2o[im] <-> 1 slnt[im] + 3 nadph[im] + 5 h[im]
R09371[im]	1 amet[im] + 1 seln[im] <-> 1 ahcys[im] + 1 C05703[im]
#Sulfur metabolism
BPNT21	1 paps[c] + 1 h2o[c] -> 1 aps[c] + 1 pi[c]
SULR_syn1	1 h2s[c] + 6 fdxox[c] + 3 h2o[c] <-> 1 so3[c] + 6 fdxrd[c] + 6 h[c]
SLFAT1	1 adp[c] + 1 h[c] + 1 so4[c] -> 1 pi[c] + 1 aps[c]
SULR1	1 so3[c] + 3 nadph[c] + 3 h[c] -> 1 h2s[c] + 3 nadp[c] + 3 h2o[c]
CYANST1	1 tsul[c] + 1 cyan[c] <-> 1 so3[c] + 1 tcynt[c]
PAPSR1	1 trdrd[c] + 1 paps[c] -> 1 trdox[c] + 1 so3[c] + 1 pap[c]
R07210[c]	1 C15521[c] + 1 fmnh2[c] + 1 o2[c] <-> 1 C00071[c] + 1 fmn[c] + 1 so3[c] + 1 h2o[c]
R10151[c]	1 tsul[c] + 5 h2o[c] + 8 ficytC[c] -> 2 so4[c] + 8 focytcc553[c] + 7 h[c]
FDMO21	1 mso3[c] + 1 fmnh2[c] + 1 o2[c] <-> 1 fmn[c] + 1 so3[c] + 1 h2o[c] + 1 fald[c]
#Starch and sucrose metabolism
TREH1	1 tre[c] + 1 h2o[c] -> 2 glc__D[c]
GALUi1	1 utp[c] + 1 g1p[c] -> 1 ppi[c] + 1 udpg[c]
HEX11	1 atp[c] + 1 glc__D[c] -> 1 adp[c] + 1 g6p[c]
R00308[c]	1 C00965[c] + 1 h2o[c] -> 1 glc__D[c]
R00760[c]	1 atp[c] + 1 fru[c] <-> 1 adp[c] + 1 C00085[c]
R00771[c]	1 g6p[c] <-> 1 C00085[c]
R00803[c]	1 sucr[c] + 1 pi[c] -> 1 fru[c] + 1 g1p[c]
R00811[c]	1 sucr[c] + 1 C04261[c] -> 1 C16688[c] + 1 C00615[c]
GLGC1	1 atp[c] + 1 g1p[c] -> 1 ppi[c] + 1 adpglc[c]
R01823[c]	1 sucr[c] -> 1 fru[c] + 1 C00718[c]
R02110[c]	2 C00718[c] -> 1 starch[c]
R02120[c]	1 sucr[c] -> 1 fru[c] + 1 C00372[c]
R02121[c]	1 C00372[c] <-> 1 C00718[c]
R02421[c]	1 adpglc[c] -> 1 adp[c] + 1 C00718[c]
UG6PGT1	1 udpg[c] + 1 g6p_A[c] -> 1 udp[c] + 1 tre6p[c]
TRE6PP1	1 tre6p[c] + 1 h2o[c] -> 1 tre[c] + 1 pi[c]
R03118[c]	1 udpg[c] -> 1 udp[c] + 1 C00965[c]
R03526[c]	1 udpg[c] + 1 C01335[c] -> 1 udp[c] + 1 C00963[c]
R03527[c]	1 C00963[c] + 1 h2o[c] -> 1 glc__D[c] + 1 C01335[c]
FFSD1	1 C16688[c] + 1 h2o[c] -> 1 fru[c] + 1 g6p[c]
R04111[c]	1 C04261[c] + 1 malt[c] <-> 1 C00615[c] + 1 malt6p[c]
R10486[c]	1 malt6p[c] + 1 h2o[c] <-> 1 malt[c] + 1 pi[c]
R11310[c]	1 g1p_B[c] <-> 1 g6p[c]
R01790[c]	1 starch[c] + 1 h2o[c] -> 1 glc__D[c]
R904[c]	4 g1p[c] -> 1 glycogen[c] + 4 pi[c]
PGMT_B1	1 g1p_B[c] <-> 1 g6p_B[c]
#The Citric Acid (TCA) cycle
PDHam1hi1	1 pyr[im] + 1 thmpp[im] -> 1 2ahethmpp[im] + 1 co2[im]
R03270[im]	1 2ahethmpp[im] + 1 C15972[im] -> 1 C16255[im] + 1 thmpp[im]
R07618[im]	1 C15973[im] + 1 nad[im] <-> 1 C15972[im] + 1 nadh[im] + 1 h[im]
R02569[im]	1 accoa[im] + 1 C15973[im] <-> 1 coa[im] + 1 C16255[im]
PC1	1 h[im] + 1 atp[im] + 1 pyr[im] + 1 hco3[im] -> 1 adp[im] + 1 pi[im] + 1 oaa[im]
PPCK1	1 atp[im] + 1 oaa[im] -> 1 adp[im] + 1 pep[im] + 1 co2[im]
CS1	1 accoa[im] + 1 h2o[im] + 1 oaa[im] -> 1 cit[im] + 1 coa[im]
ACONTa1	1 cit[im] <-> 1 acon_C[im] + 1 h2o[im]
ACONTb1	1 icit[im] <-> 1 acon_C[im] + 1 h2o[im]
r04231	1 icit[im] + 1 nadp[im] <-> 1 HC01434[im] + 1 nadph[im] + 1 h[im]
r00821	1 HC01434[im] -> 1 akg[im] + 1 co2[im]
ICDHxm1	1 icit[im] + 1 nad[im] -> 1 akg[im] + 1 co2[im] + 1 nadh[im] + 1 h[im]
r01631	1 akg[im] + 1 thmpp[im] -> 1 HC01435[im] + 1 co2[im]
R03316[im]	1 HC01435[im] + 1 C15972[im] -> 1 C16254[im] + 1 thmpp[im]
R02570[im]	1 succoa[im] + 1 C15973[im] <-> 1 coa[im] + 1 C16254[im]
R10343[im]	1 succoa[im] + 1 ac[im] <-> 1 accoa[im] + 1 succ[im]
SUCOAS1	1 atp[im] + 1 succ[im] + 1 coa[im] -> 1 adp[im] + 1 pi[im] + 1 succoa[im]
FUM1	1 mal__L[im] <-> 1 fum[im] + 1 h2o[im]
ICDHym1	1 icit[im] + 1 nadp[im] -> 1 akg[im] + 1 co2[im] + 1 nadph[im] + 1 h[im]
#Oxydative phosphorylation
R200[im]	1 nadh[im] -> 1 nad[im] + 1 h[im] + 2 C05359[im]
R201[im]	1 fad[im] + 2 C05359[im] + 2 h[im] -> 1 fadh2[im]
R202[im]	2 h[im] + 1 fadh2[im] -> 4 h[om] + 1 fad[im] + 2 C05359[im]
R203[im]	0.5 o2[im] + 4 h[im] + 2 C05359[im] -> 1 h2o[im] + 2 h[om]
R204[im]	1 pi[im] + 1 adp[im] + 3 h[om] -> 3 h[im] + 1 atp[im] + 1 h2o[im]
R205[im]	2 nadh[im] + 10 h[im] + 0.5 o2[im] -> 2 nad[im] + 10 h[om] + 1 h2o[im] + 2 C05359[im]
R02164[im]	1 fad[im] + 1 succ[im] <-> 1 fadh2[im] + 1 fum[im]
#Pentose phosphate pathway
R01049[c]	1 atp[c] + 1 C00117[c] <-> 1 amp[c] + 1 prpp[c]
R01051[c]	1 atp[c] + 1 rib__D[c] <-> 1 adp[c] + 1 C00117[c] + 1 h[c]
URIH1	1 uri[c] + 1 h2o[c] <-> 1 ura[c] + 1 rib__D[c]
R01056[c]	1 C00117[c] <-> 1 ru5p__D[c]
GND1	1 6pgc[c] + 1 nadp[c] -> 1 ru5p__D[c] + 1 co2[c] + 1 nadph[c] + 1 h[c]
RPEh1	1 ru5p__D[c] <-> 1 xu5p__D[c]
R01827[c]	1 s7p[c] + 1 g3p[c] <-> 1 e4p[c] + 1 f6p_B[c]
PGL1	1 6pgl[c] + 1 h2o[c] -> 1 6pgc[c]
G6PBDH1	1 g6p_B[c] + 1 nadp[c] -> 1 6pgl[c] + 1 nadph[c] + 1 h[c]
R10221[c]	1 6pgc[c] + 1 nad[c] -> 1 ru5p__D[c] + 1 co2[c] + 1 nadh[c] + 1 h[c]
R10907[c]	1 g6p_B[c] + 1 nad[c] -> 1 6pgl[c] + 1 nadh[c] + 1 h[c]
#purine metabolism 
XPPT1	1 xan[c] + 1 prpp[c] -> 1 ppi[c] + 1 xmp[c]
RNTR21	1 gtp[c] + 1 trdrd[c] -> 1 dgtp[c] + 1 h2o[c] + 1 trdox[c]
RNTR11	1 atp[c] + 1 trdrd[c] -> 1 datp[c] + 1 h2o[c] + 1 trdox[c]
DGK11	1 atp[c] + 1 dgmp[c] <-> 1 adp[c] + 1 dgdp[c]
GLUPRT1	1 pram[c] + 1 ppi[c] + 1 glu__L[c] <-> 1 gln__L[c] + 1 prpp[c] + 1 h2o[c]
CBMKr1	1 atp[c] + 1 nh4[c] + 1 co2[c] -> 1 adp[c] + 1 cbp[c]
ADNCYC1	1 atp[c] -> 1 camp[c] + 1 ppi[c]
PRAGSr1	1 atp[c] + 1 pram[c] + 1 gly[c] <-> 1 adp[c] + 1 pi[c] + 1 gar[c]
R04325[c]	1 10fthf[c] + 1 gar[c] -> 1 thf[c] + 1 fgam[c]
R04463[c]	1 atp[c] + 1 fgam[c] + 1 gln__L[c] + 1 h2o[c] -> 1 adp[c] + 1 pi[c] + 1 C04640[c] + 1 glu__L[c]
R04208[c]	1 C04640[c] + 1 atp[c] -> 1 C03373[c] + 1 adp[c] + 2 h[c] + 1 pi[c]
R04209[c]	1 5aizc[c] <-> 1 C03373[c] + 1 co2[c]
R04591[c]	1 atp[c] + 1 5aizc[c] + 1 asp__L[c] -> 1 adp[c] + 1 pi[c] + 1 25aics[c]
R04559[c]	1 25aics[c] -> 1 fum[c] + 1 aicar[c]
AICART21	1 for[c] + 1 atp[c] + 1 aicar[c] <-> 1 adp[c] + 1 pi[c] + 1 fprica[c]
IMPC1	1 fprica[c] <-> 1 imp[c] + 1 h2o[c]
IMPD1	1 imp[c] + 1 nad[c] + 1 h2o[c] -> 1 xmp[c] + 1 nadh[c] + 1 h[c]
ADSS1	1 gtp[c] + 1 imp[c] + 1 asp__L[c] -> 1 gdp[c] + 1 pi[c] + 1 dcamp[c]
NDPK8m1	1 atp[c] + 1 dadp[c] -> 1 adp[c] + 1 datp[c]
DAPOP1	1 dadp[c] + 1 pep[c] -> 1 datp[c] + 1 pyr[c]
GUAPRT1	1 gua[c] + 1 prpp[c] -> C00144[c] + 1 C00013[c]
GMPS1	1 atp[c] + 1 xmp[c] + 1 nh4[c] -> 1 amp[c] + 1 ppi[c] + 1 gmp[c]
GMPS21	1 atp[c] + 1 xmp[c] + 1 gln__L[c] + 1 h2o[c] -> 1 amp[c] + 1 ppi[c] + 1 gmp[c] + 1 glu__L[c]
NDPK51	1 atp[c] + 1 dgdp[c] -> 1 adp[c] + 1 dgtp[c]
AGPOP1	1 dgdp[c] + 1 pep[c] -> 1 dgtp[c] + 1 pyr[c]
ALLTAHr1	1 alltt[c] + 1 h2o[c] <-> 1 urdglyc[c] + 1 urea[c]
R02425[c]	1 C02350[c] + 1 h2o[c] <-> 1 alltt[c]
HIUH1	1 5hiu[c] + 1 h2o[c] -> 1 5houdic[c]
RNDR11	1 trdrd[c] + 1 adp[c] -> 1 dadp[c] + 1 trdox[c] + 1 h2o[c]
ADSL1r1	1 dcamp[c] -> 1 fum[c] + 1 amp[c]
ADSK1	1 atp[c] + 1 aps[c] -> 1 adp[c] + 1 paps[c]
GTPOPm1	1 gdp[c] + 1 pep[c] -> 1 gtp[c] + 1 pyr[c]
NDPK11	1 atp[c] + 1 gdp[c] -> 1 adp[c] + 1 gtp[c]
GK11	1 atp[c] + 1 gmp[c] -> 1 adp[c] + 1 gdp[c]
AMPDA1	1 amp[c] + 1 h2o[c] -> 1 imp[c] + 1 nh4[c]
ADPT1	1 ade[c] + 1 prpp[c] -> 1 amp[c] + 1 ppi[c]
NTPP61	1 atp[c] + 1 h2o[c] -> 1 amp[c] + 1 ppi[c]
ADK1m1	1 atp[c] + 1 amp[c] -> 2 adp[c]
UREA1	1 urea[c] + 1 h2o[c] -> 1 co2[c] + 2 nh4[c]
DADA1	1 dad_2[c] + 1 h2o[c] <-> 1 din[c] + 1 nh4[c]
PUNP61	1 din[c] + 1 pi[c] -> 1 hxan[c] + 1 2dr1p[c]
PUNP51	1 ins[c] + 1 pi[c] <-> 1 hxan[c] + 1 r1p[c]
ADAe1	1 adn[c] + 1 h2o[c] -> 1 ins[c] + 1 nh4[c]
ATDAMh1	1 atp[c] + 1 damp[c] <-> 1 adp[c] + 1 dadp[c]
R00776[c]	1 urdglyc[c] <-> 1 glx[c] + 1 urea[c]
PUNP11	1 adn[c] + 1 pi[c] <-> 1 ade[c] + 1 r1p[c]
NTD71	1 amp[c] + 1 h2o[c] -> 1 adn[c] + 1 pi[c]
NTD11pp1	1 imp[c] + 1 h2o[c] -> 1 ins[c] + 1 pi[c]
NTD101	1 xmp[c] + 1 h2o[c] -> 1 xtsn[c] + 1 pi[c]
PUNP71	1 xtsn[c] + 1 pi[c] <-> 1 xan[c] + 1 r1p[c]
XAO2x1	1 hxan[c] + 1 o2[c] + 1 h2o[c] <-> 1 xan[c] + 1 h2o2[c]
GUAD_11	1 gua[c] + 1 h2o[c] -> 1 xan[c] + 1 nh4[c]
PUNP31	1 gsn[c] + 1 pi[c] <-> 1 gua[c] + 1 r1p[c]
NTD91	1 gmp[c] + 1 h2o[c] <-> 1 gsn[c] + 1 pi[c]
NTD61	1 damp[c] + 1 h2o[c] <-> 1 dad_2[c] + 1 pi[c]
PUNP21	1 dad_2[c] + 1 pi[c] <-> 1 ade[c] + 1 2dr1p[c]
DADNKn1	1 atp[c] + 1 dad_2[c] -> 1 adp[c] + 1 damp[c]
XAOx1	1 xan[c] + 1 h2o[c] + 1 o2[c] -> 1 urate[c] + 1 h2o2[c]
URO1	1 urate[c] + 1 o2[c] + 1 h2o[c] -> 1 5hiu[c] + 1 h2o2[c]
R03925[c]	1 C02350[c] <-> 1 C02348[c]
R06605[c]	1 5houdic[c] + 1 h[c] <-> 1 C02348[c] + 1 co2[c]
RNDR21	1 gdp[c] + 1 trdrd[c] -> 1 dgdp[c] + 1 trdox[c] + 1 h2o[c]
#Pyramidine metabolism
RNTR41	1 utp[c] + 1 trdrd[c] -> 1 dutp[c] + 1 h2o[c] + 1 trdox[c]
RNTR31	1 ctp[c] + 1 trdrd[c] -> 1 dctp[c] + 1 h2o[c] + 1 trdox[c]
DCTCP1	1 dctp[c] + 1 cytd[c] -> 1 dcdp[c] + 1 cmp[c]
DUTCP1	1 dutp[c] + 1 cytd[c] -> 1 dudp[c] + 1 cmp[c]
DCTUP1	1 dctp[c] + 1 uri[c] -> 1 dcdp[c] + 1 ump[c]
DTTGY1	1 dttp[c] + 1 cytd[c] -> 1 dtdp[c] + 1 cmp[c]
DTTUP1	1 dttp[c] + 1 uri[c] -> 1 dtdp[c] + 1 ump[c]
URIK21	1 gtp[c] + 1 uri[c] -> 1 gdp[c] + 1 ump[c]
CYTDK21	1 gtp[c] + 1 cytd[c] -> 1 gdp[c] + 1 cmp[c]
UTCY1	1 utp[c] + 1 cytd[c] -> 1 udp[c] + 1 cmp[c]
CBPS1	2 atp[c] + 1 gln__L[c] + 1 hco3[c] + 1 h2o[c] -> 2 adp[c] + 1 pi[c] + 1 glu__L[c] + 1 cbp[c]
DUTUP1	1 dutp[c] + 1 uri[c] -> 1 dudp[c] + 1 ump[c]
DATCY1	1 datp[c] + 1 cytd[c] -> 1 dadp[c] + 1 cmp[c]
DATUP1	1 datp[c] + 1 uri[c] -> 1 dadp[c] + 1 ump[c]
UTUP1	1 utp[c] + 1 uri[c] -> 1 udp[c] + 1 ump[c]
CYTDK11	1 atp[c] + 1 cytd[c] -> 1 adp[c] + 1 cmp[c]
ASPCT_11	1 cbp[c] + 1 asp__L[c] -> 1 pi[c] + 1 cbasp[c]
DHORTSn1	1 dhor__S[c] + 1 h2o[c] <-> 1 cbasp[c]
R01868[c]	1 dhor__S[c] + 1 fad[c] <-> 1 orot[c] + 1 fadh2[c]
ORPT1	1 orot[c] + 1 prpp[c] <-> 1 orot5p[c] + 1 ppi[c]
OMPDC1	1 orot5p[c] -> 1 ump[c] + 1 co2[c]
UMPKm1	1 atp[c] + 1 ump[c] -> 1 adp[c] + 1 udp[c]
NDPK21	1 atp[c] + 1 udp[c] -> 1 adp[c] + 1 utp[c]
CTPS11	1 atp[c] + 1 utp[c] + 1 nh4[c] -> 1 adp[c] + 1 pi[c] + 1 ctp[c]
NDPK31	1 adp[c] + 1 ctp[c] -> 1 atp[c] + 1 cdp[c]
RNDR31	1 trdrd[c] + 1 cdp[c] -> 1 dcdp[c] + 1 trdox[c] + 1 h2o[c]
TRDR1	1 trdox[c] + 1 nadph[c] + 1 h[c] -> 1 trdrd[c] + 1 nadp[c]
CYTD1	1 cytd[c] + 1 h2o[c] -> 1 uri[c] + 1 nh4[c]
DURIPP1	1 duri[c] + 1 pi[c] <-> 1 ura[c] + 1 2dr1p[c]
CSND1	1 csn[c] + 1 h2o[c] -> 1 ura[c] + 1 nh4[c]
NTD41	1 cmp[c] + 1 h2o[c] -> 1 cytd[c] + 1 pi[c]
CYTDH1	1 cytd[c] + 1 h2o[c] -> 1 csn[c] + 1 rib__D[c]
PYNP2r1	1 uri[c] + 1 pi[c] <-> 1 ura[c] + 1 r1p[c]
URIK11	1 atp[c] + 1 uri[c] -> 1 adp[c] + 1 ump[c]
CYTK1m1	1 atp[c] + 1 cmp[c] <-> 1 adp[c] + 1 cdp[c]
CTPS21	1 atp[c] + 1 utp[c] + 1 gln__L[c] + 1 h2o[c] -> 1 adp[c] + 1 pi[c] + 1 ctp[c] + 1 glu__L[c]
DCMPDA1	1 dcmp[c] + 1 h2o[c] -> 1 dump[c] + 1 nh4[c]
CYTK21	1 atp[c] + 1 dcmp[c] <-> 1 adp[c] + 1 dcdp[c]
DGTUP1	1 dgtp[c] + 1 uri[c] -> 1 dgdp[c] + 1 ump[c]
RNDR41	1 trdrd[c] + 1 udp[c] -> 1 dudp[c] + 1 trdox[c] + 1 h2o[c]
URIDK2r1	1 atp[c] + 1 dump[c] -> 1 adp[c] + 1 dudp[c]
NDPK7m1	1 atp[c] + 1 dcdp[c] -> 1 adp[c] + 1 dctp[c]
NDPK61	1 atp[c] + 1 dudp[c] -> 1 adp[c] + 1 dutp[c]
DURIK11	1 atp[c] + 1 duri[c] -> 1 adp[c] + 1 dump[c]
R02101[c]	1 dump[c] + 1 mlthf[c] -> 1 dhf[c] + 1 dtmp[c]
DTMPK1	1 atp[c] + 1 dtmp[c] -> 1 adp[c] + 1 dtdp[c]
NDPK4m1	1 atp[c] + 1 dtdp[c] -> 1 adp[c] + 1 dttp[c]
#Pyramidine metabolism
GTHOr1	1 gthox[im] + 1 h[im] + 1 nadph[im] -> 2 gthrd[im] + 1 nadp[im]
#One carbon pool by folate
R00941[c]	1 thf[c] + 1 nadph[c] + 1 h[c] -> 1 10fthf[c] + 1 nadp[c] + 1 h2o[c]
R00939[c]	1 dhf[c] + 1 nadph[c] + 1 h[c] -> 1 thf[c] + 1 nadp[c]
FTCL1	1 atp[c] + 1 5fthf[c] + 1 h[c] -> 1 adp[c] + 1 pi[c] + 1 methf[c]
R03940[c]	1 mettrna[c] + 1 10fthf[c] <-> 1 thf[c] + 1 fmettrna[c]
R04326[c]	1 gar[c] + 1 methf[c] + 1 h2o[c] <-> 1 h[c] + 1 fgam[c] + 1 thf[c]
R07168[c]	1 mlthf[c] + 1 nadh[c] + 1 h[c] -> 1 5mthf[c] + 1 nad[c]
R00943[c]	1 thf[c] + 1 for[c] + 1 atp[c] -> 1 adp[c] + 1 pi[c] + 1 10fthf[c]
R03940[im]	1 mettrna[im] + 1 10fthf[im] <-> 1 thf[im] + 1 fmettrna[im]
R00943[im]	1 thf[im] + 1 for[im] + 1 atp[im] -> 1 adp[im] + 1 pi[im] + 1 10fthf[im]
THFAT1	1 h[im] + 1 5fthf[im] -> 1 methf[im] + 1 h2o[im]
FTCL1	1 atp[im] + 1 5fthf[im] + 1 h[im] -> 1 adp[im] + 1 pi[im] + 1 methf[im]
#Folate biosynthesis
DHFS1	1 atp[c] + 1 dhpt[c] + 1 glu__L[c] -> 1 adp[c] + 1 pi[c] + 1 dhf[c]
R04241[c]	1 atp[c] + 1 glu__L[c] <-> 1 adp[c] + 1 pi[c] + 1 C03541[c]
R09395[c]	1 C18239[c] + 2 C15814[c] <-> 1 mpt[c] + 2 C15810[c]
#Alanine, Aspartate, and Glutamate metabolism
ASNS21	1 atp[c] + 1 asp__L[c] + 1 nh4[c] -> 1 amp[c] + 1 ppi[c] + 1 asn__L[c]
GLUDxi1	1 glu__L[c] + 1 nad[c] + 1 h2o[c] -> 1 akg[c] + 1 nh4[c] + 1 nadh[c] + 1 h[c]
GDH_nadp1	1 glu__L[c] + 1 nadp[c] + 1 h2o[c] -> 1 akg[c] + 1 nh4[c] + 1 nadph[c] + 1 h[c]
GLNS1	1 atp[c] + 1 glu__L[c] + 1 nh4[c] -> 1 adp[c] + 1 pi[c] + 1 gln__L[c]
GLUSx1	1 gln__L[c] + 1 akg[c] + 1 nadh[c] + 1 h[c] -> 2 glu__L[c] + 1 nad[c]
GLUNpp1	1 gln__L[c] + 1 h2o[c] -> 1 glu__L[c] + 1 nh4[c]
GLUDC1	1 glu__L[c] -> 1 4abut[c] + 1 co2[c]
ASPTA1	1 asp__L[c] + 1 akg[c] -> 1 oaa[c] + 1 glu__L[c]
AGTi1	1 ala__L[c] + 1 glx[c] -> 1 pyr[c] + 1 gly[c]
ASP4DC1	1 asp__L[c] + 1 h[c] <-> 1 ala__L[c] + 1 co2[c]
SSALxm1	1 sucsal[c] + 1 nad[c] + 1 h2o[c] -> 1 succ[c] + 1 nadh[c] + 1 h[c]
SSALy1	1 sucsal[c] + 1 nadp[c] + 1 h2o[c] -> 1 succ[c] + 1 nadph[c] + 1 h[c]
ARGSL1	1 argsuc[c] -> 1 fum[c] + 1 arg__L[c]
ABTA1	1 4abut[c] + 1 akg[c] -> 1 sucsal[c] + 1 glu__L[c]
ARGSS1	1 atp[c] + 1 citr__L[c] + 1 asp__L[c] -> 1 amp[c] + 1 ppi[c] + 1 argsuc[c]
R10178[c]	1 4abut[c] + 1 pyr[c] <-> 1 sucsal[c] + 1 ala__L[c]
#Glycine, Serine, and Thrione metabolism
BETALDHy1	1 betald[c] + 1 nadp[c] + 1 h2o[c] -> 1 glyb[c] + 1 nadph[c] + 2 h[c]
GLYTA_11	1 glx[c] + 1 glu__L[c] -> 1 gly[c] + 1 akg[c]
SERD_L1	1 ser__L[c] -> 1 pyr[c] + 1 nh4[c]
GLYOp1	1 gly[c] + 1 h2o[c] + 1 o2[c] -> 1 glx[c] + 1 nh4[c] + 1 h2o2[c]
ASPK_11	1 atp[c] + 1 asp__L[c] -> 1 adp[c] + 1 4pasp[c]
PSP_L1	1 pser__L[c] + 1 h2o[c] -> 1 ser__L[c] + 1 pi[c]
CYS1	1 ser__L[c] + 1 h2s[c] -> 1 cys__L[c] + 1 h2o[c]
THRD_L1	1 thr__L[c] -> 1 2obut[c] + 1 nh4[c]
R01290[c]	1 ser__L[c] + 1 hcys__L[c] -> 1 cyst__L[c] + 1 h2o[c]
PGCD1	1 3pg[c] + 1 nad[c] -> 1 3php[c] + 1 nadh[c] + 1 h[c]
HSK1	1 atp[c] + 1 hom__L[c] -> 1 adp[c] + 1 phom[c]
HSDxi1	1 aspsa[c] + 1 nadh[c] + 1 h[c] -> 1 hom__L[c] + 1 nad[c]
HSDy1	1 aspsa[c] + 1 nadph[c] + 1 h[c] -> 1 hom__L[c] + 1 nadp[c]
R01800[c]	1 cdpdag_cho[c] + 1 ser__L[c] <-> 1 cmp[c] + 1 ps_cho[c]
ASAD1	1 aspsa[c] + 1 pi[c] + 1 nadp[c] <-> 1 4pasp[c] + 1 nadph[c] + 1 h[c]
AMO1	1 aact[c] + 1 h2o[c] + 1 o2[c] <-> 1 mthgxl[c] + 1 nh4[c] + 1 h2o2[c]
TRPS21	1 ser__L[c] + 1 indole[c] -> 1 trp__L[c] + 1 h2o[c]
PSERT1	1 pser__L[c] + 1 akg[c] <-> 1 3php[c] + 1 glu__L[c]
CHOLD1	1 chol[c] + 1 nad[c] -> 1 betald[c] + 1 nadh[c] + 1 h[c]
R08558[c]	1 chol[c] + 1 nadp[c] -> 1 betald[c] + 1 nadph[c] + 1 h[c]
GLYCK1	1 atp[c] + 1 glyc__R[c] -> 1 adp[c] + 1 3pg[c]
SERD_D1	1 ser__D[c] <-> 1 pyr[c] + 1 nh4[c]
SPT_syn1	1 ser__L[c] + 1 glx[c] -> 1 hpyr[c] + 1 gly[c]
SPTix1	1 ser__L[c] + 1 pyr[c] -> 1 hpyr[c] + 1 ala__L[c]
THRS_11	1 phom[c] + 1 h2o[c] -> 1 thr__L[c] + 1 pi[c]
R06171[c]	1 athr__L[c] <-> 1 gly[c] + 1 acald[c]
ATHRDHr1	1 athr__L[c] + 1 nadp[c] -> 1 2aobut[c] + 1 nadph[c] + 1 h[c]
AOBUTDsm1	1 2aobut[c] -> 1 aact[c] + 1 co2[c]
GCCcm1	1 dhlpro[c] + 1 nad[c] -> 1 lpro[c] + 1 nadh[c] + 1 h[c]
#Histidine metabolism
R01163[c]	1 C01929[c] + 1 h2o[c] + 1 nad[c] -> 1 his__L[c] + 1 nadh[c] + 1 h[c]
R03012[c]	1 histd[c] + 1 nad[c] -> 1 C01929[c] + 1 nadh[c] + 1 h[c]
HSTPT1	1 hisp[c] + 1 akg[c] <-> 1 imacp[c] + 1 glu__L[c]
IGPDH1	1 eig3p[c] -> 1 imacp[c] + 1 h2o[c]
PRICIh1	1 prfp[c] <-> 1 prlp[c]
HPh1	1 hisp[c] + 1 h2o[c] -> 1 histd[c] + 1 pi[c]
IG3PS1	1 prlp[c] + 1 gln__L[c] -> 1 aicar[c] + 1 eig3p[c] + 1 h[c] + 1 glu__L[c]
ATPPRT1	1 atp[c] + 1 prpp[c] -> 1 prbatp[c] + 1 ppi[c]
PRATPP1	1 prbatp[c] + 1 h2o[c] -> 1 prbamp[c] + 1 ppi[c]
PRACHh1	1 prbamp[c] + 1 h2o[c] -> 1 prfp[c]
R00254[c]	1 glu__L[c] + 1 nh4[c] + 1 co2[c] <-> 1 C05829[c] + 1 h2o[c]
#Thiamine biosynthesis
R00619[c]	1 atp[c] + 1 C00378[c] -> 1 amp[c] + 1 thmpp[c]
R02135[c]	1 thmmp[c] + 1 h2o[c] <-> 1 C00378[c] + 1 pi[c]
R10712[c]	1 h[c] + 1 2mahmp[c] + 1 C20247[c] <-> 1 thmmp[c] + 1 ppi[c] + 1 co2[c]
R10685[c]	1 nad[c] + 1 gly[c] + 1 h2s[c] <-> 1 C20784[c] + 1 ncam[c] + 3 h2o[c] + 1 h[c]
R04509[c]	1 atp[c] + 1 C04556[c] -> 1 adp[c] + 1 2mahmp[c]
PYDXK1	1 atp[c] + 1 pydx[c] -> 1 adp[c] + 1 pydx5p[c]
R10686[c]	1 pydx5p[c] + 1 his__L[c] -> 1 C04556[c]
R10711[c]	1 C20784[c] + 1 h2o[c] -> 1 C20247[c] + 1 amp[c]
#Arginine and Proline metabolism
HPROa1	1 4hpro_LT[c] + 1 nad[c] -> 1 1p3h5c[c] + 1 nadh[c] + 1 h[c]
ARGN1	1 arg__L[c] + 1 h2o[c] <-> 1 orn[c] + 1 urea[c]
ORNCD1	1 orn[c] -> 1 pro__L[c] + 1 nh4[c]
P5CR1	1 1pyr5c[c] + 1 nadph[c] + 1 h[c] -> 1 pro__L[c] + 1 nadp[c]
G5SD1	1 glu5sa[c] + 1 pi[c] + 1 nadp[c] <-> 1 glu5p[c] + 1 nadph[c] + 1 h[c]
ADMDC1	1 h[c] + 1 amet[c] -> 1 co2[c] + 1 ametam[c]
R01914[c]	1 spmd[c] + 1 o2[c] + 1 h2o[c] -> 1 C00986[c] + 1 4abutn[c] + 1 h2o2[c]
SPMS1	1 ametam[c] + 1 ptrc[c] -> 1 5mta[c] + 1 spmd[c]
SPRMS1	1 ametam[c] + 1 spmd[c] -> 1 5mta[c] + 1 sprm[c]
POLYAO31	1 sprm[c] + 1 o2[c] + 1 h2o[c] <-> 1 spmd[c] + 1 aproa[c] + 1 h2o2[c]
ORNDC1	1 orn[c] -> 1 ptrc[c] + 1 co2[c]
GLU5Km1	1 atp[c] + 1 glu__L[c] -> 1 adp[c] + 1 glu5p[c]
G5SADrm1	1 glu5sa[c] <-> 1 1pyr5c[c] + 1 h2o[c]
#Phenylalanine, Tryptophane, and tyrosine biosynthesis
ATNS_nh41	1 chor[im] + 1 nh4[im] -> 1 anth[im] + 1 pyr[im] + 1 h2o[im]
ATNS_nh41	1 chor[c] + 1 nh4[c] -> 1 anth[c] + 1 pyr[c] + 1 h2o[c]
ANS1	1 chor[c] + 1 gln__L[c] -> 1 anth[c] + 1 pyr[c] + 1 glu__L[c]
CHRS1	1 3psme[c] <-> 1 chor[c] + 1 pi[c]
DDPA1	1 pep[c] + 1 e4p[c] + 1 h2o[c] <-> 1 2dda7p[c] + 1 pi[c]
TRPS31	1 3ig3p[c] <-> 1 indole[c] + 1 g3p[c]
SKK1	1 atp[c] + 1 skm[c] <-> 1 adp[c] + 1 skm5p[c]
SHK3Dr1	1 skm[c] + 1 nadp[c] <-> 1 3dhsk[c] + 1 nadph[c] + 1 h[c]
DHQS1	1 2dda7p[c] <-> 1 3dhq[c] + 1 pi[c]
DHQTi1	1 3dhq[c] <-> 1 3dhsk[c] + 1 h2o[c]
PSCVT1	1 pep[c] + 1 skm5p[c] <-> 1 pi[c] + 1 3psme[c]
CHORM1	1 chor[c] <-> 1 pphn[c]
PHETA11	1 phe__L[c] + 1 akg[c] <-> 1 phpyr[c] + 1 glu__L[c]
TYRTA1	1 tyr__L[c] + 1 akg[c] <-> 1 34hpp[c] + 1 glu__L[c]
PRAIi1	1 pran[c] -> 1 2cpr5p[c]
ANPRT1	1 pran[c] + 1 ppi[c] <-> 1 anth[c] + 1 prpp[c]
IGPS1	1 2cpr5p[c] + 1 h[c] -> 1 3ig3p[c] + 1 co2[c] + 1 h2o[c]
PPNDH1	1 pphn[c] <-> 1 phpyr[c] + 1 h2o[c] + 1 co2[c]
PPND21	1 pphn[c] + 1 nadp[c] <-> 1 34hpp[c] + 1 co2[c] + 1 nadph[c] + 1 h[c]
#phenylalanine metabolism
PEAMNOpp1	1 peamn[c] + 1 o2[c] + 1 h2o[c] <-> 1 pacald[c] + 1 nh4[c] + 1 h2o2[c]
R06942[c]	1 C14144[c] + 1 h2o[c] <-> 1 3hadpcoa[c]
3OXCOAT1	1 coa[c] + 1 oxadpcoa[c] -> 1 succoa[c] + 1 accoa[c]
#Tryptophan metabolism
R03629[c]	1 C01598[c] + 1 C03024[c] + 1 o2[c] <-> 1 C05643[c] + 1 C03161[c] + 1 h2o[c]
R04909[c]	1 5hxkynam[c] + 1 co2[c] <-> 1 C05651[c]
TRPOX1	1 trp__L[c] + 1 h2o[c] + 1 o2[c] -> 1 indpyr[c] + 1 nh4[c] + 1 h2o2[c]
INDPYRD1	1 indpyr[c] -> 1 id3acald[c] + 1 co2[c]
ALCD26xim1	1 h[c] + 1 id3acald[c] + 1 nadh[c] -> 1 nad[c] + 1 ind3eth[c]
TRPO21	1 trp__L[c] + 1 o2[c] -> 1 Lfmkynr[c]
FKYNH1	1 h2o[c] + 1 Lfmkynr[c] -> 1 for[c] + 1 h[c] + 1 Lkynr[c]
QUILSYN1	1 cmusa[c] -> 1 quln[c] + 1 h2o[c]
R03130[c]	1 amet[c] + 1 C00978[c] -> 1 ahcys[c] + 1 C01598[c]
KYN1	1 Lkynr[c] + 1 h2o[c] -> 1 anth[c] + 1 ala__L[c]
KYN3OX1	1 Lkynr[c] + 1 o2[c] + 1 nadph[c] + 1 h[c] <-> 1 hLkynr[c] + 1 nadp[c] + 1 h2o[c]
3HAO1	1 3hanthrn[c] + 1 o2[c] <-> 1 cmusa[c]
HKYNH1	1 hLkynr[c] + 1 h2o[c] <-> 1 3hanthrn[c] + 1 ala__L[c]
R02670[c]	2 3hanthrn[c] + 4 o2[c] <-> 1 C05640[c] + 2 o2s[c] + 2 h2o2[c] + 2 h[c]
R03936[c]	1 Lfmkynr[c] + 1 h2o[c] <-> 1 C05653[c] + 1 ala__L[c]
PCLAD1	1 cmusa[c] <-> 1 am6sa[c] + 1 co2[c]
#Tyrosine metabolism
R01395[c]	1 atp[c] + 1 cbm[c] -> 1 adp[c] + 1 cbp[c]
DOPABMO1	1 dopa[c] + 1 ascb__L[c] + 1 o2[c] -> 1 nrpphr[c] + 1 dhdascb[c] + 1 h2o[c]
R04892[c]	1 C05583[c] + 1 nadp[c] + 1 h2o[c] -> 1 C05584[c] + 1 nadph[c] + 1 h[c]
R04894[c]	1 C05588[c] + 1 h2o[c] + 1 o2[c] -> 1 C05583[c] + 1 h2o2[c] + 1 mma[c]
R04893[c]	1 normete__L[c] + 1 h2o[c] + 1 o2[c] -> 1 C05583[c] + 1 nh4[c] + 1 h2o2[c]
R04891[c]	1 C05583[c] + 1 nad[c] + 1 h2o[c] -> 1 C05584[c] + 1 nadh[c] + 1 h[c]
R04882[c]	1 34dhmald[c] + 1 nad[c] + 1 h2o[c] <-> 1 C05580[c] + 1 nadh[c] + 1 h[c]
R02533[c]	1 amet[c] + 1 nrpphr[c] <-> 1 ahcys[c] + 1 C00788[c]
TYRCBOX1	1 tyr__L[c] <-> 1 tym[c] + 1 co2[c]
FUMAH1	1 fumpyr[c] + 1 h2o[c] -> 1 fum[c] + 1 pyr[c]
FUMAC1	1 4fumacac[c] + 1 h2o[c] -> 1 acac[c] + 1 fum[c]
R02080[c]	1 C00355[c] <-> 1 dopa[c] + 1 co2[c]
TYROXDApp1	1 tym[c] + 1 h2o[c] + 1 o2[c] <-> 1 4hoxpacd[c] + 1 nh4[c] + 1 h2o2[c]
HGNTOR1	1 hgentis[c] + 1 o2[c] <-> 1 4mlacac[c]
SALMCOM1	1 amet[c] + 1 nrpphr[c] <-> 1 ahcys[c] + 1 normete__L[c]
R02920[c]	1 amet[c] + 1 C00788[c] <-> 1 ahcys[c] + 1 C05588[c]
MAAIn1	1 4mlacac[c] <-> 1 4fumacac[c]
R03304[c]	1 amet[c] + 1 34dhpacet[c] <-> 1 ahcys[c] + 1 C05582[c]
R03868[c]	1 C02167[c] <-> 1 fumpyr[c]
42A12BOOX1	1 dopa[c] + 1 h2o[c] + 1 o2[c] -> 1 34dhpac[c] + 1 nh4[c] + 1 h2o2[c]
DOPAMT1	1 amet[c] + 1 dopa[c] <-> 1 ahcys[c] + 1 3moxtyr[c]
34DHOXPEGOX1	1 34dhoxpeg[c] + 1 nad[c] <-> 1 34dhmald[c] + 1 nadh[c] + 1 h[c]
R04881[c]	1 amet[c] + 1 34dhoxpeg[c] <-> 1 ahcys[c] + 1 C05594[c]
R04887[c]	1 amet[c] + 1 C05580[c] <-> 1 ahcys[c] + 1 C05584[c]
34HPPOR1	1 34hpp[c] + 1 o2[c] -> 1 hgentis[c] + 1 co2[c]
34DHPLACOX_NADP1	1 34dhpac[c] + 1 nadp[c] + 1 h2o[c] <-> 1 34dhpacet[c] + 1 nadph[c] + 1 h[c]
R04888[c]	1 3mox4hpac[c] + 1 nad[c] + 1 h2o[c] -> 1 C05582[c] + 1 nadh[c] + 1 h[c]
R04889[c]	1 3mox4hpac[c] + 1 nadp[c] + 1 h2o[c] -> 1 C05582[c] + 1 nadph[c] + 1 h[c]
3MOXTYROX1	1 3moxtyr[c] + 1 h2o[c] + 1 o2[c] -> 1 3mox4hpac[c] + 1 h2o2[c] + 1 nh4[c]
#Eumelanin synthesis
R02078[c]	1 tyr__L[c] + 1 o2[c] -> 1 C00822[c] + 1 h2o[c]
R00731[c]	1 tyr__L[c] + 1 o2[c] -> 1 C00355[c] + 1 h2o[c]
R00045[e]	1 o2[e] + 2 C00355[e] -> 2 C00822[e] + 2 h2o[e]
R02962[e]	1 C00822[e] -> 1 C05604[e]
R03672[e]	1 C05604[e] + 1 C00822[e] -> 1 C01693[e] + 1 C00355[e]
R03674[e]	1 C01693[e] -> 1 C05578[e] + 1 co2[e]
R04884[e]	2 C05578[e] + 1 o2[e] -> 2 C05579[e] + 2 h2o[e]
R04886[e]	1 C05579[e] + 1 o2[e] -> 1 C17937Eu[e] + 1 h2o[e]
#Pyomelanin synthesis
R902[c]	1 hgentis[c] + 0.5 o2[c] -> 1 X00002[c] + 1 h2o[c]
R903[e]	1 X00002[e] -> 1 C17937Pyo[e] + 1 h2o[e]
#Pentose and glucuronate interconversion
RBK_Dr1	1 atp[c] + 1 rbl__D[c] <-> 1 adp[c] + 1 ru5p__D[c]
R01542[c]	1 2ddglcn[c] + 1 nad[c] <-> 1 C04349[c] + 1 nadh[c] + 1 h[c]
XYLTD_D1	1 xylt[c] + 1 nad[c] <-> 1 xylu__D[c] + 1 nadh[c] + 1 h[c]
#Fructose and mannose metabolism
SBTD_D21	1 sbt__D[c] + 1 nad[c] <-> 1 fru[c] + 1 nadh[c] + 1 h[c]
PMANM1	1 man6p[c] <-> 1 man1p[c]
R00877[c]	1 gdpmann[c] -> 1 fru[c]
R01819[c]	1 man6p[c] <-> 1 f6p_B[c]
FCLPA1	1 fc1p[c] <-> 1 dhap[c] + 1 lald__L[c]
ALLPI1	1 all6p[c] <-> 1 allul6p[c]
R00887[c]	1 gdpmann[c] <-> 1 gdp[c] + 1 C00464[c]
MAN1PT1	1 man1p[c] + 1 gtp[c] -> 1 ppi[c] + 1 gdpmann[c]
#Heme Synthesis
UPP3S_11	1 hmbil[c] <-> 1 uppg3[c] + 1 h2o[c]
UPPDC21	1 uppg1[c] <-> 1 cpppg1[c] + 4 co2[c]
R03222[c]	1 pppg9[c] + 3 o2[c] <-> 1 ppp9[c] + 3 h2o2[c]
ALASm1	1 succoa[c] + 1 gly[c] -> 1 5aop[c] + 1 coa[c] + 1 co2[c]
CPPPGO1	1 cpppg3[c] + 1 o2[c] <-> 1 pppg9[c] + 2 co2[c] + 2 h2o[c]
HMBS1	4 ppbng[c] + 1 h2o[c] <-> 1 hmbil[c] + 4 nh4[c]
PPBNGS1	2 5aop[c] <-> 1 ppbng[c] + 2 h2o[c]
IDIh1	1 ipdp[c] -> 1 dmpp[c]
R02480[c]	1 cytc[c] <-> 1 apocytc[c] + 1 pheme[c]
DMATT1	1 dmpp[c] + 1 ipdp[c] -> 1 ppi[c] + 1 grdp[c]
GRTT1	1 grdp[c] + 1 ipdp[c] -> 1 ppi[c] + 1 frdp[c]
R07411[c]	1 pheme[c] + 1 h2o[c] + 1 frdp[c] -> 1 hemeO[c] + 1 ppi[c]
HEMEAS_11	1 hemeO[c] <-> 1 hemeA[c]
#Riboflavin metabolism
R09376[c]	1 25drapp[c] + 1 nadph[c] + 1 h[c] -> 1 C18910[c] + 1 nadp[c]
FADDP1	1 fad[c] + 1 h2o[c] <-> 1 amp[c] + 1 fmn[c]
ACP1_FMN1	1 fmn[c] + 1 h2o[c] -> 1 ribflv[c] + 1 pi[c]
RBFK1	1 atp[c] + 1 ribflv[c] -> 1 adp[c] + 1 fmn[c]
RBFSb1	2 dmlz[c] -> 1 ribflv[c] + 1 4r5au[c]
RBFSa1	1 4r5au[c] + 1 db4p[c] <-> 1 dmlz[c] + 2 h2o[c] + 1 pi[c]
DB4PS1	1 ru5p__D[c] -> 1 db4p[c] + 1 for[c]
R00425[c]	1 gtp[c] + 3 h2o[c] <-> 1 for[c] + 1 25drapp[c] + 1 ppi[c]
R03459[c]	1 25drapp[c] + 1 h2o[c] <-> 1 5apru[c] + 1 nh4[c]
AUNOR1	1 5aprbu[c] + 1 nadp[c] <-> 1 5apru[c] + 1 nadph[c] + 1 h[c]
PMDPHT1	1 5aprbu[c] + 1 h2o[c] <-> 1 4r5au[c] + 1 pi[c]
#Galactose Metabolism
UDPG4E1	1 udpg[c] <-> 1 udpgal[c]
SUCRe1	1 sucr[c] + 1 h2o[c] -> 1 fru[c] + 1 glc__D[c]
TGBPA1	1 tagdp__D[c] <-> 1 dhap[c] + 1 g3p[c]
PFK_21	1 tag6p__D[c] + 1 atp[c] -> 1 tagdp__D[c] + 1 adp[c]
R03237[c]	1 ctp[c] + 1 tag6p__D[c] -> 1 cdp[c] + 1 tagdp__D[c]
R03238[c]	1 utp[c] + 1 tag6p__D[c] -> 1 udp[c] + 1 tagdp__D[c]
GRGT1	1 1Dgali[c] + 1 raffin[c] <-> 1 inost[c] + 1 stys[c]
R05168[c]	1 acgal6p[c] + 1 h2o[c] <-> 1 galam6p[c] + 1 ac[c]
#Fatty acid biosynthesis
3OAR1201	1 3hddecACP[im] + 1 nadp[im] <-> 1 3oddecACP[im] + 1 nadph[im] + 1 h[im]
ACOAD1f1	1 btcoa[im] + 1 fad[im] <-> 1 fadh2[im] + 1 b2coa[im]
R04751[im]	1 C05270[im] + 1 fad[im] -> 1 hx2coa[im] + 1 fadh2[im]
R04754[im]	1 dccoa[im] + 1 fad[im] -> 1 dc2coa[im] + 1 fadh2[im]
ACOAD3f1	1 occoa[im] + 1 fad[im] -> 1 oc2coa[im] + 1 fadh2[im]
ACOA140OR1	1 tdcoa[im] + 1 fad[im] -> 1 td2coa[im] + 1 fadh2[im]
ACOAD7f1	1 pmtcoa[im] + 1 fad[im] -> 1 hdd2coa[im] + 1 fadh2[im]
FACOAL160p1	1 atp[im] + 1 hdca[im] + 1 coa[im] <-> 1 amp[im] + 1 pmtcoa[im] + 1 ppi[im]
ACOATA1	1 accoa[im] + 1 ACP[im] <-> 1 coa[im] + 1 acACP[im]
MCOATA1	1 malcoa[im] + 1 ACP[im] <-> 1 coa[im] + 1 malACP[im]
3HAD120_11	1 3hddecACP[im] <-> 1 tddec2eACP[im] + 1 h2o[im]
R04967[im]	1 C05761[im] + 1 nadp[im] <-> 1 tmrs2eACP[im] + 1 nadph[im] + 1 h[im]
R04968[im]	1 C05761[im] + 1 malACP[im] <-> 1 3opalmACP[im] + 1 co2[im] + 1 ACP[im]
R04970[im]	1 C05764[im] + 1 nadp[im] <-> 1 tpalm2eACP[im] + 1 nadph[im] + 1 h[im]
3OAR60_11	1 3hhexACP[im] + 1 nadp[im] <-> 1 3ohexACP[im] + 1 nadph[im] + 1 h[im]
3HAD60_11	1 3hhexACP[im] <-> 1 thex2eACP[im] + 1 h2o[im]
R04956[im]	1 C05749[im] + 1 nadp[im] <-> 1 thex2eACP[im] + 1 nadph[im] + 1 h[im]
R04957[im]	1 C05749[im] + 1 malACP[im] <-> 1 3ooctACP[im] + 1 co2[im] + 1 ACP[im]
R04959[im]	1 C05752[im] + 1 nadp[im] <-> 1 toct2eACP[im] + 1 nadph[im] + 1 h[im]
R04960[im]	1 C05752[im] + 1 malACP[im] <-> 1 3odecACP[im] + 1 co2[im] + 1 ACP[im]
R04962[im]	1 C05755[im] + 1 nadp[im] <-> 1 tdec2eACP[im] + 1 nadph[im] + 1 h[im]
R04963[im]	1 C05755[im] + 1 malACP[im] <-> 1 3oddecACP[im] + 1 co2[im] + 1 ACP[im]
R04725[im]	1 C05223[im] + 1 nadp[im] <-> 1 tddec2eACP[im] + 1 nadph[im] + 1 h[im]
R04726[im]	1 C05223[im] + 1 malACP[im] <-> 1 3omrsACP[im] + 1 co2[im] + 1 ACP[im]
R04952[im]	1 C05745[im] + 1 malACP[im] <-> 1 3ohexACP[im] + 1 co2[im] + 1 ACP[im]
3HAD40_11	1 3hbutACP[im] <-> 1 but2eACP[im] + 1 h2o[im]
R04430[im]	1 C05745[im] + 1 nadp[im] <-> 1 but2eACP[im] + 1 nadph[im] + 1 h[im]
3OAR40_11	1 3hbutACP[im] + 1 nadp[im] <-> 1 actACP[im] + 1 nadph[im] + 1 h[im]
3OAR100_11	1 3hdecACP[im] + 1 nadp[im] <-> 1 h[im] + 1 3odecACP[im] + 1 nadph[im]
3HAD1001	1 3hdecACP[im] <-> 1 tdec2eACP[im] + 1 h2o[im]
3OAR801	1 3hoctACP[im] + 1 nadp[im] <-> 1 3ooctACP[im] + 1 nadph[im] + 1 h[im]
3HAD801	1 3hoctACP[im] <-> 1 toct2eACP[im] + 1 h2o[im]
3OAR1601	1 3hpalmACP[im] + 1 nadp[im] <-> 1 3opalmACP[im] + 1 nadph[im] + 1 h[im]
3HAD1601	1 3hpalmACP[im] <-> 1 tpalm2eACP[im] + 1 h2o[im]
3OAR1401	1 3hmrsACP[im] + 1 nadp[im] <-> 1 3omrsACP[im] + 1 nadph[im] + 1 h[im]
3HAD1401	1 3hmrsACP[im] <-> 1 tmrs2eACP[im] + 1 h2o[im]
KAS14_11	1 acACP[im] + 1 malACP[im] <-> 1 actACP[im] + 1 co2[im] + 1 ACP[im]
ACCOACrm1	1 atp[im] + 1 accoa[im] + 1 hco3[im] <-> 1 adp[im] + 1 pi[im] + 1 malcoa[im]
R01706[im]	1 C05764[im] + 1 h2o[im] <-> 1 ACP[im] + 1 hdca[im]
R07762[im]	1 C05764[im] + 1 malACP[im] <-> 1 C16219[im] + 1 ACP[im] + 1 co2[im]
R07763[im]	1 C16219[im] + 1 nadph[im] + 1 h[im] <-> 1 3hoctaACP[im] + 1 nadp[im]
3HAD1801	1 3hoctaACP[im] <-> 1 toctd2eACP[im] + 1 h2o[im]
R07765[im]	1 toctd2eACP[im] + 1 nadh[im] + 1 h[im] <-> 1 C04088[im] + 1 nad[im]
R03370[im]	1 C04088[im] + 2 fdxrd[im] + 1 o2[im] + 2 h[im] <-> 1 C01203[im] + 2 fdxox[im] + 2 h2o[im]
R08163[im]	1 C04088[im] + 1 h2o[im] <-> 1 ACP[im] + 1 ocdca[im]
R02814[im]	1 C01203[im] + 1 h2o[im] <-> 1 ACP[im] + 1 ocdcea[im]
#Fatty acid elongation
R02685[c]	1 3hacoa[c] <-> 1 C00658[c] + 1 h2o[c]
ECOAH5_11	1 3hddcoa[c] <-> 1 dd2coa[c] + 1 h2o[c]
ECOAH7p1	1 3hhdcoa[c] <-> 1 hdd2coa[c] + 1 h2o[c]
ECOAH61	1 3htdcoa[c] <-> 1 td2coa[c] + 1 h2o[c]
ECOAH41	1 3hdcoa[c] <-> 1 dc2coa[c] + 1 h2o[c]
ECOAH3_11	1 3hocoa[c] <-> 1 oc2coa[c] + 1 h2o[c]
ECOAH21	1 3hhcoa[c] <-> 1 hx2coa[c] + 1 h2o[c]
R10825[c]	1 C20876[c] + 1 malcoa[c] <-> 1 C20877[c] + 1 co2[c] + 1 coa[c]
R10826[c]	1 C20878[c] + 1 nadp[c] <-> 1 C20877[c] + 1 nadph[c] + 1 h[c]
R10827[c]	1 C20878[c] <-> 1 C20879[c] + 1 h2o[c]
KATp1	2 accoa[im] <-> 1 coa[im] + 1 3oacoa[im]
ACACT2r1	1 coa[im] + 1 3ohcoa[im] -> 1 accoa[im] + 1 btcoa[im]
FACOAE1601	1 pmtcoa[im] + 1 h2o[im] -> 1 coa[im] + 1 hdca[im]
ACACT4r1	1 occoa[im] + 1 accoa[im] <-> 1 coa[im] + 1 3odcoa[im]
ACACT6p1	1 ddcacoa[im] + 1 accoa[im] <-> 1 coa[im] + 1 3otdcoa[im]
ACACT7p1	1 tdcoa[im] + 1 accoa[im] <-> 1 coa[im] + 1 3ohdcoa[im]
ACACT5r_11	1 dccoa[im] + 1 accoa[im] <-> 1 coa[im] + 1 3oddcoa[im]
R04747[im]	1 C05270[im] + 1 accoa[im] <-> 1 coa[im] + 1 3oocoa[im]
R09450[im]	1 C02843[im] + 1 h2o[im] <-> 1 C00638[im] + 1 coa[im]
HACD2i1	1 3hhcoa[im] + 1 nad[im] <-> 1 3ohcoa[im] + 1 nadh[im] + 1 h[im]
HACD31	1 3hocoa[im] + 1 nad[im] <-> 1 3oocoa[im] + 1 nadh[im] + 1 h[im]
HACD41	1 3hdcoa[im] + 1 nad[im] <-> 1 3odcoa[im] + 1 nadh[im] + 1 h[im]
HACD51	1 3hddcoa[im] + 1 nad[im] <-> 1 3oddcoa[im] + 1 nadh[im] + 1 h[im]
ECOAH21	1 3hhcoa[im] <-> 1 hx2coa[im] + 1 h2o[im]
ECOAH3_11	1 3hocoa[im] <-> 1 oc2coa[im] + 1 h2o[im]
ECOAH41	1 3hdcoa[im] <-> 1 dc2coa[im] + 1 h2o[im]
ECOAH5_11	1 3hddcoa[im] <-> 1 dd2coa[im] + 1 h2o[im]
ECOAH61	1 3htdcoa[im] <-> 1 td2coa[im] + 1 h2o[im]
ECOAH7p1	1 3hhdcoa[im] <-> 1 hdd2coa[im] + 1 h2o[im]
R06985[im]	1 hx2coa[im] + 1 nadph[im] + 1 h[im] <-> 1 C05270[im] + 1 nadp[im]
ACOAR3m1	1 occoa[im] + 1 nadp[im] <-> 1 oc2coa[im] + 1 nadph[im] + 1 h[im]
R04753[im]	1 dccoa[im] + 1 nadp[im] <-> 1 dc2coa[im] + 1 nadph[im] + 1 h[im]
ACOAR5m1	1 ddcacoa[im] + 1 nadp[im] <-> 1 dd2coa[im] + 1 nadph[im] + 1 h[im]
ACOAR6m1	1 tdcoa[im] + 1 nadp[im] <-> 1 td2coa[im] + 1 nadph[im] + 1 h[im]
ACOAR7m1	1 pmtcoa[im] + 1 nadp[im] <-> 1 hdd2coa[im] + 1 nadph[im] + 1 h[im]
#Fatty acid degredation
R00623[c]	1 C00226[c] + 1 nad[c] <-> 1 C00071[c] + 1 nadh[c] + 1 h[c]
R04756[c]	1 C05280[c] <-> 1 C05279[c]
ACACT1x1	2 accoa[im] <- 1 coa[im] + 1 aacoa[im]
R04121[im]	3 h[im] + 1 C03024[im] + 1 C00162[im] + 1 o2[im] <-> 1 C05102[im] + 1 C03161[im] + 1 h2o[im]
R04756[im]	1 C05280[im] <-> 1 C05279[im]
HACD71	1 3hhdcoa[im] + 1 nad[im] <-> 1 3ohdcoa[im] + 1 nadh[im] + 1 h[im]
HACD6i1	1 3htdcoa[im] + 1 nad[im] <-> 1 3otdcoa[im] + 1 nadh[im]
HACD1i1	1 3hbcoa[im] + 1 nad[im] <-> 1 aacoa[im] + 1 nadh[im] + 1 h[im]
#fixed this reaction direction after having fixed the use of generic acceptors (C00028/C00030)
ACOAD5f1	1 ddcacoa[im] + 1 fad[im] -> 1 dd2coa[im] + 1 fadh2[im]
#Fatty acid metabolism
COA1819ZD9DS1	1 strcoa[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] <-> 1 ocdce9coa[c] + 2 ficytb5[c] + 2 h2o[c]
#Glyoxylate and dicarboxylate metabolism
R01221[c]	1 gly[c] + 1 thf[c] + 1 nad[c] -> 1 mlthf[c] + 1 nh4[c] + 1 co2[c] + 1 nadh[c] + 1 h[c]
HOXPRx1	1 2h3oppan[c] + 1 nadh[c] + 1 h[c] -> 1 glyc__R[c] + 1 nad[c]
CAT1	2 h2o2[c] -> 1 o2[c] + 2 h2o[c]
MALS1	1 accoa[c] + 1 h2o[c] + 1 glx[c] -> 1 mal__L[c] + 1 coa[c]
FDH1	1 for[c] + 1 nad[c] -> 1 h[c] + 1 co2[c] + 1 nadh[c]
PGLYCP1	1 2pglyc[c] + 1 h2o[c] -> 1 glyclt[c] + 1 pi[c]
R01747[c]	1 2h3oppan[c] + 1 nadph[c] + 1 h[c] -> 1 glyc__R[c] + 1 nadp[c]
#CoA biosynthesis
DPCOAK1	1 atp[c] + 1 dpcoa[c] -> 1 adp[c] + 1 coa[c] + 1 h[c]
R01209[c]	1 C04039[c] <-> 1 3mob[c] + 1 h2o[c]
R03051[c]	1 C00900[c] + 1 nadph[c] + 1 h[c] -> 1 C04039[c] + 1 nadp[c]
R00006[c]	2 pyr[c] -> 1 C00900[c] + 1 co2[c]
ASP1DC1	1 asp__L[c] -> 1 ala_B[c] + 1 co2[c]
DPR1	1 pant__R[c] + 1 nadp[c] <-> 1 2dhp[c] + 1 nadph[c] + 1 h[c]
DPCOAPP1	1 dpcoa[c] + 1 h2o[c] <-> 1 pan4p[c] + 1 amp[c]
PPCDC1	1 4ppcys[c] -> 1 pan4p[c] + 1 co2[c]
PPNCL31	1 atp[c] + 1 4ppan[c] + 1 cys__L[c] -> 1 amp[c] + 1 ppi[c] + 1 4ppcys[c]
PPNCL21	1 ctp[c] + 1 4ppan[c] + 1 cys__L[c] -> 1 cmp[c] + 1 ppi[c] + 1 4ppcys[c]
PANTS1	1 atp[c] + 1 pant__R[c] + 1 ala_B[c] -> 1 amp[c] + 1 ppi[c] + 1 pnto__R[c]
R01226[c]	1 mlthf[c] + 1 3mob[c] + 1 h2o[c] -> 1 thf[c] + 1 2dhp[c]
#Nicotinate and nicotinamide mtabolism
NADDPp1	1 nad[c] + 1 h2o[c] -> 1 amp[c] + 1 nmn[c] + 1 h[c]
DNADDP1	1 dnad[c] + 1 h2o[c] -> 1 amp[c] + 1 nicrnt[c]
NMNAT1	1 h[c] + 1 atp[c] + 1 nmn[c] -> 1 ppi[c] + 1 nad[c]
NAMNPP1	1 nicrnt[c] + 1 ppi[c] + 1 adp[c] + 1 pi[c] <-> 1 nac[c] + 1 prpp[c] + 1 atp[c] + 1 h2o[c] + 1 h[c]
NNATr1	1 atp[c] + 1 nicrnt[c] -> 1 ppi[c] + 1 dnad[c]
NNDPRm1	1 nicrnt[c] + 1 ppi[c] + 1 co2[c] <-> 1 h[c] + 1 quln[c] + 1 prpp[c]
#Pyruvate metabolism
R00196[c]	1 lac__L[c] + 2 ficytC[c] -> 1 pyr[c] + 2 focytcc553[c] + 2 h[c]
ACCOACrm1	1 atp[c] + 1 accoa[c] + 1 hco3[c] <-> 1 adp[c] + 1 pi[c] + 1 malcoa[c]
r00681	1 HC01672[c] + 1 coa[c] -> 1 amp[c] + 1 accoa[c]
ACKrh1	1 atp[c] + 1 ac[c] -> 1 adp[c] + 1 actp[c]
r00971	1 atp[c] + 1 ac[c] <-> 1 ppi[c] + 1 HC01672[c]
R00320[c]	1 ppi[c] + 1 ac[c] <-> 1 pi[c] + 1 actp[c]
MDHy1	1 mal__L[c] + 1 nadp[c] -> 1 oaa[c] + 1 nadph[c] + 1 h[c]
R00928[c]	1 accoa[c] + 1 C00163[c] <-> 1 ac[c] + 1 ppcoa[c]
DMALRED1	1 mal__L[c] + 1 fad[c] <-> 1 oaa[c] + 1 fadh2[c]
R01447[c]	1 lac__L[c] + 1 oaa[c] <-> 1 mal__L[c] + 1 pyr[c]
LacR1	1 lac__L[c] <-> 1 lac__D[c]
GLYOX1	1 lgt__S[c] + 1 h2o[c] -> 1 gthrd[c] + 1 lac__D[c]
LGTHL1	1 lgt__S[c] <-> 1 gthrd[c] + 1 mthgxl[c]
R10866[c]	1 pyr[c] + 1 coa[c] + 1 fldox[c] <-> 1 accoa[c] + 1 co2[c] + 1 fldrd[c]
R00197[im]	1 lac__D[im] + 2 ficytC[im] -> 1 pyr[im] + 2 focytcc553[im] + 2 h[im]
ALDD2x1	1 acald[im] + 1 nad[im] + 1 h2o[im] <-> 1 ac[im] + 1 nadh[im] + 1 h[im]
R00198[im]	1 lac__D[im] + 2 C01070[im] <-> 1 pyr[im] + 2 C01071[im] + 2 h[im]
R00211[im]	1 pyr[im] + 1 coa[im] + 1 o2[im] <-> 1 h2o2[im] + 1 accoa[im] + 1 co2[im]
R00229[im]	1 atp[im] + 1 ac[im] + 1 coa[im] -> 1 adp[im] + 1 accoa[im] + 1 pi[im]
r00681	1 HC01672[im] + 1 coa[im] -> 1 amp[im] + 1 accoa[im]
r00971	1 atp[im] + 1 ac[im] <-> 1 ppi[im] + 1 HC01672[im]
ACYP_21	1 actp[im] + 1 h2o[im] -> 1 ac[im] + 1 pi[im]
LO1	1 lac__L[im] + 1 o2[im] -> 1 ac[im] + 1 co2[im] + 1 h2o[im]
MDHm1	1 mal__L[im] + 1 nad[im] <-> 1 oaa[im] + 1 nadh[im] + 1 h[im]
R00346[im]	1 ppi[im] + 1 oaa[im] <-> 1 pi[im] + 1 pep[im] + 1 co2[im]
#Arginine biosynthesis
ACODA1	1 acorn[c] + 1 h2o[c] -> 1 ac[c] + 1 orn[c]
UREASE1	1 atp[c] + 1 urea[c] + 1 hco3[c] -> 1 adp[c] + 1 pi[c] + 1 allphn[c]
ACGS1	1 accoa[c] + 1 glu__L[c] -> 1 coa[c] + 1 acglu[c]
ORNTAC1	1 acorn[c] + 1 glu__L[c] -> 1 orn[c] + 1 acglu[c]
R09107[c]	1 C15532[c] + 1 h2o[c] <-> 1 ac[c] + 1 citr__L[c]
OCBTm1	1 cbp[c] + 1 orn[c] <-> 1 pi[c] + 1 citr__L[c]
ACGK1	1 atp[c] + 1 acglu[c] -> 1 adp[c] + 1 acg5p[c]
AGPRim1	1 acg5p[c] + 1 nadph[c] + 1 h[c] -> 1 acg5sa[c] + 1 pi[c] + 1 nadp[c]
ACOTA1	1 acg5sa[c] + 1 glu__L[c] -> 1 akg[c] + 1 acorn[c]
ALPHNH1	1 allphn[c] + 1 h2o[c] -> 2 co2[c] + 2 nh4[c]
ALATA_L1	1 ala__L[c] + 1 akg[c] -> 1 pyr[c] + 1 glu__L[c]
#propanoate metabolism
R00926[c]	1 C05983[c] + 1 coa[c] -> 1 amp[c] + 1 ppcoa[c]
3HPCOAHYD1	1 3hpp[c] + 1 coa[c] <-> 1 3hpcoa[c] + 1 h2o[c]
PRPNCOAHYDm1	1 3hpcoa[c] <-> 1 prpncoa[c] + 1 h2o[c]
#n-clycan biosynthesis
R01004[c]	1 doldp[c] + 1 h2o[c] <-> 1 C00110[c] + 1 pi[c] + 1 h[c]
#microbial metabolism in diverse environments
ICL1	1 icit[c] -> 1 glx[c] + 1 succ[c]
R06848[c]	1 C12835[c] + 2 nadh[c] + 2 h[c] <-> 1 C12836[c] + 1 C01327[c] + 2 nad[c]
R02988[c]	1 3oxoadp[c] + 1 nad[c] -> 1 C02222[c] + 1 nadh[c] + 1 h[c]
R05358[c]	1 C01998[c] + 2 h2o[c] <-> 1 acryl[c] + 1 nh4[c]
R05355[c]	1 C06329[c] + 1 nadh[c] <-> 1 C02222[c] + 1 nad[c] + 1 cl[c]
R09138[c]	1 C18243[c] + 2 nadph[c] + 2 h[c] -> 1 C18244[c] + 2 nadp[c] + 1 C01327[c]
R09223[c]	1 C18305[c] + 1 nadh[c] + 1 h[c] <-> 1 C18306[c] + 1 nad[c] + 1 C01327[c]
R09224[c]	1 C18306[c] + 1 nadh[c] + 1 h[c] <-> 1 C18307[c] + 1 nad[c]
R09137[c]	1 C18243[c] + 2 nadh[c] + 2 h[c] -> 1 C18244[c] + 2 nad[c] + 1 C01327[c]
R09099[c]	1 ser__L[c] + 1 h4mpt[c] <-> 1 C04377[c] + 1 gly[c] + 1 h2o[c]
R01067[c]	1 C00085[c] + 1 g3p[c] <-> 1 e4p[c] + 1 xu5p__D[c]
R00756[c]	1 atp[c] + 1 C00085[c] -> 1 adp[c] + 1 fdp[c]
SFGTHi1	1 Sfglutth[c] + 1 h2o[c] -> 1 for[c] + 1 gthrd[c]
FBA1	1 dhap[c] + 1 g3p[c] -> 1 fdp[c]
ICDHym1	1 icit[c] + 1 nadp[c] -> 1 akg[c] + 1 co2[c] + 1 nadph[c] + 1 h[c]
R01224[c]	1 mlthf[c] + 1 nadph[c] + 1 h[c] -> 1 5mthf[c] + 1 nadp[c]
R01440[c]	1 xu5p__D[c] + 1 fald[c] -> 1 g3p[c] + 1 dha[c]
PYDXOR1	1 pydxn[c] + 1 nadp[c] <-> 1 pydx[c] + 1 nadph[c] + 1 h[c]
PYDXO_11	1 pydam[c] + 1 h2o[c] + 1 o2[c] <-> 1 pydx[c] + 1 nh4[c] + 1 h2o2[c]
PYDXNO1	1 pydxn[c] + 1 o2[c] -> 1 pydx[c] + 1 h2o2[c]
R03893[c]	1 C04431[c] + 1 h2o[c] <-> 1 C02222[c]
R03997[c]	1 C02625[c] + 1 o2[c] + 1 nadph[c] + 1 h[c] <-> 1 C02933[c] + 1 nadp[c] + 1 h2o[c]
R05233[c]	1 C06611[c] + 1 nad[c] <-> 1 C06613[c] + 1 nadh[c] + 1 h[c]
R05234[c]	1 C06612[c] + 1 nad[c] <-> 1 C16348[c] + 1 nadh[c] + 1 h[c]
R05441[c]	1 C02124[c] + 1 o2[c] + 1 nadph[c] + 1 h[c] <-> 1 C02375[c] + 1 nadp[c] + 1 h2o[c]
R05510[c]	1 C07090[c] + 1 h2o[c] <-> 1 C07091[c]
R05511[c]	1 C04706[c] + 1 h2o[c] <-> 1 C06329[c]
R05632[c]	1 C03203[c] + 1 nadh[c] + 1 h[c] + 1 o2[c] <-> 1 npthld[c] + 1 co2[c] + 1 nad[c] + 1 h2o[c]
VNDH1	1 vanln[c] + 1 nad[c] + 1 h2o[c] <-> 1 vanlt[c] + 1 nadh[c] + 1 h[c]
R06622[c]	1 nadph[c] + 1 C01147[c] + 1 h[c] + 1 o2[c] <-> 1 nadp[c] + 1 C12314[c] + 1 h2o[c]
R06835[c]	1 C12834[c] + 1 h2o[c] <-> 1 C12835[c]
R06838[c]	1 C12838[c] + 1 h2o[c] <-> 1 C02222[c]
R06915[c]	1 C14088[c] + 1 o2[c] + 1 nadh[c] + 1 h[c] <-> 1 3mcat[c] + 1 nad[c] + 1 co2[c] + 1 h2o[c]
R06917[c]	1 C14089[c] + 1 nad[c] <-> 1 C14090[c] + 1 nadh[c] + 1 h[c]
R06927[c]	1 C02909[c] + 1 nad[c] <-> 1 C14099[c] + 1 nadh[c] + 1 h[c]
R06936[c]	1 C14109[c] + 1 o2[c] + 1 nadh[c] + 1 h[c] <-> 1 C14110[c] + 1 nad[c] + 1 h2o[c] + 1 co2[c]
R06939[c]	1 C14103[c] + 1 o2[c] + 1 nadh[c] + 1 h[c] <-> 1 4mcat[c] + 1 nad[c] + 1 h2o[c] + 1 co2[c]
R06945[c]	1 C11249[c] + 1 o2[c] + 1 nadh[c] + 1 h[c] <-> 1 C00854[c] + 1 nad[c] + 1 h2o[c]
FALGTHLs1	1 gthrd[c] + 1 fald[c] <-> 1 hmgth[c]
FALDH21	1 hmgth[c] + 1 nad[c] -> 1 Sfglutth[c] + 1 nadh[c] + 1 h[c]
R07827[c]	1 C05618[c] + 1 o2[c] <-> 1 C16266[c]
R09221[c]	1 C18303[c] <-> 1 C18304[c] + 1 C01327[c]
R09222[c]	1 C18304[c] + 1 h2o[c] <-> 1 C18305[c]
#Diterpenoid synthesis
R03008[c]	1 ga1_cho[c] + 1 akg[c] + 1 o2[c] <-> 1 C03579[c] + 1 succ[c] + 1 co2[c]
R03809[c]	1 C02035[c] + 1 akg[c] + 1 o2[c] <-> 1 C06096[c] + 1 succ[c] + 1 co2[c]
R06337[c]	1 C11863[c] + 1 akg[c] + 1 o2[c] <-> 1 C11865[c] + 1 succ[c] + 1 co2[c]
R06338[c]	1 C11864[c] + 1 akg[c] + 1 o2[c] <-> 1 C11868[c] + 1 succ[c] + 1 co2[c]
R06342[c]	1 C11868[c] <-> 1 C11869[c] + 1 h2[c]
R06343[c]	1 C11865[c] <-> 1 C11854[c] + 1 h2[c]
R06344[c]	1 C06096[c] <-> 1 C11855[c] + 1 h2[c]
R06345[c]	1 C03579[c] <-> 1 C11870[c] + 1 h2[c]
#Biosynthesis of amino acids
HISTD1	1 histd[c] + 2 nad[c] + 1 h2o[c] -> 1 his__L[c] + 2 nadh[c] + 2 h[c]
PRO1xm1	1 1pyr5c[c] + 1 nadh[c] + 1 h[c] -> 1 pro__L[c] + 1 nad[c]
#Sphinoslipid metabolism
R06516[c]	1 C06124[c] <-> 1 ethamp[c] + 1 C06123[c]
UGCG_cho1	1 udpg[c] + 1 crm_cho[c] <-> 1 udp[c] + 1 gluside_cho[c]
R06518[c]	1 dhcrm_cho[c] + 1 h2o[c] -> 1 C00162[c] + 1 sphgn[c]
SBPP11	1 sph1p[c] + 1 h2o[c] <-> 1 sphgn[c] + 1 pi[c]
R06521[c]	1 C06124[c] + 1 h2o[c] <-> 1 C00319[c] + 1 pi[c]
R06522[c]	1 crmp_cho[c] + 1 h2o[c] <-> 1 crm_cho[c] + 1 pi[c]
R06525[c]	1 sphgn[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] -> 1 psphings[c] + 2 ficytb5[c] + 1 h2o[c]
R06526[c]	1 dhcrm_cho[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] -> 1 C12145[c] + 2 ficytb5[c] + 1 h2o[c]
R06528[c]	1 C12145[c] + 1 h2o[c] -> 1 C00162[c] + 1 psphings[c]
SERPT1	1 pmtcoa[c] + 1 ser__L[c] -> 1 3dsphgn[c] + 1 coa[c] + 1 co2[c]
SPHPL1	1 sph1p[c] <-> 1 ethamp[c] + 1 hxdcal[c]
#Arachidonic acid metabolism
R01590[c]	1 C00219[c] + 2 o2[c] -> 1 HC02217[c]
R00073[c]	1 HC02217[c] + 1 nad[c] -> 1 C00427[c] + 1 nadh[c] + 1 h2o[c]
R02581[c]	1 C00639[c] + 1 nadp[c] <-> 1 C00584[c] + 1 nadph[c] + 1 h[c]
R03057[c]	1 leuktrA4[c] + 1 h2o[c] <-> 1 C02165[c]
#Ubiquinone and other terpenoid-quinone biosynthesis
R04983[c]	1 C05803[c] + 1 amet[c] <-> 1 C05804[c] + 1 ahcys[c]
COUCOAFm1	1 atp[c] + 1 T4hcinnm[c] + 1 coa[c] <-> 1 amp[c] + 1 ppi[c] + 1 coucoa[c]
R05000[c]	1 C05847[c] + 1 4hbz[c] <-> 1 C05848[c] + 1 ppi[c]
R05614[c]	1 C05815[c] + 1 amet[c] <-> 1 q8[c] + 1 ahcys[c]
HBZOPT1	1 octdp[c] + 1 4hbz[c] <-> 1 3ophb[c] + 1 ppi[c]
HBZOPT6m1	1 hexdp[c] + 1 4hbz[c] <-> 1 3ophb_5[c] + 1 ppi[c]
TOCOPHOM11	1 amet[c] + 1 gtocophe[c] <-> 1 ahcys[c] + 1 avite1[c]
R07273[c]	1 C04145[c] + 1 4hbz[c] <-> 1 ppi[c] + 1 C03885[c]
TOCOPHOM21	1 dtocophe[c] + 1 amet[c] <-> 1 bvite[c] + 1 ahcys[c]
R10491[c]	1 amet[c] + 1 C14155[c] <-> 1 ahcys[c] + 1 C14153[c]
R10492[c]	1 amet[c] + 1 C14156[c] <-> 1 ahcys[c] + 1 C14154[c]
#steroid hormone biosynthesis 
R01842[c]	1 C03024[c] + 1 o2[c] <-> 1 C05296[c] + 1 C03161[c] + 1 h2o[c]
HSD17B8r1	1 estradiol[c] + 1 nad[c] -> 1 estrone[c] + 1 nadh[c] + 1 h[c]
HSD17B11	1 estradiol[c] + 1 nadp[c] -> 1 estrone[c] + 1 nadph[c] + 1 h[c]
RE1630R1	1 C05298[c] + 1 amet[c] <-> 1 C05299[c] + 1 ahcys[c]
RE2386C1	1 C05301[c] + 1 amet[c] <-> 1 C05302[c] + 1 ahcys[c]
MERGTROLR1	1 mergtrol[c] + 1 nadph[c] + 1 h[c] <-> 1 mfecostrl[c] + 1 nadp[c]
R07484[c]	1 mfecostrl[c] <-> 1 C11522[c]
R07486[c]	1 C15782[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] <-> 1 C15783[c] + 2 ficytb5[c] + 2 h2o[c]
R07491[c]	1 epist[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] <-> 1 C15780[c] + 2 ficytb5[c] + 2 h2o[c]
R07505[c]	1 epist[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] <-> 1 C15778[c] + 2 ficytb5[c] + 2 h2o[c]
R08945[c]	1 C18075[c] + 1 nad[c] -> 1 C05284[c] + 1 nadh[c] + 1 h[c]
R08980[c]	1 C18075[c] + 1 nadp[c] -> 1 C05284[c] + 1 nadph[c] + 1 h[c]
#Steroid biosynthesis
R03353[c]	1 C01189[c] <-> 1 zymstnl[c]
R04804[c]	1 zymst[c] <-> 1 C05439[c]
R05703[c]	1 C05439[c] + 1 nadph[c] + 1 h[c] -> 1 C01189[c] + 1 nadp[c]
R07215[c]	1 C01189[c] + 2 focytb5[c] + 1 o2[c] + 2 h[c] <-> 1 C01164[c] + 2 ficytb5[c] + 2 h2o[c]
CYARTMT1	1 cyart[c] + 1 amet[c] <-> 1 menecyart[c] + 1 ahcys[c]
#Phenylpropanoid biosynthesis
CAFFCOA1	1 atp[c] + 1 34dhcinm[c] + 1 coa[c] <-> 1 amp[c] + 1 ppi[c] + 1 caffcoa[c]
FERULCOAS1	1 atp[c] + 1 fer[c] + 1 coa[c] <-> 1 amp[c] + 1 ppi[c] + 1 ferulcoa[c]
R02221[c]	1 atp[c] + 1 C00482[c] + 1 coa[c] <-> 1 amp[c] + 1 ppi[c] + 1 C00411[c]
R02255[c]	1 atp[c] + 1 cinnm[c] + 1 coa[c] <-> 1 amp[c] + 1 ppi[c] + 1 C00540[c]
R02593[c]	1 confrl[c] + 1 nadp[c] <-> 1 conialdh[c] + 1 nadph[c] + 1 h[c]
R02596[c]	1 confrl[c] <-> 1 C15805[c]
R03918[c]	1 C02325[c] + 1 nadp[c] <-> 1 C05610[c] + 1 nadph[c] + 1 h[c]
R03919[c]	1 C02325[c] <-> 1 C15806[c]
R04007[c]	1 C02646[c] <-> 1 C15804[c]
BDG2HCGHD1	1 bdg2hc[c] + 1 h2o[c] <-> 1 2coum[c] + 1 glc__D[c]
R06570[c]	1 C12204[c] + 1 nadph[c] + 1 h[c] <-> 1 C12205[c] + 1 nadp[c]
R06571[c]	1 C10945[c] + 1 nadph[c] + 1 h[c] <-> 1 C12206[c] + 1 nadp[c]
R06583[c]	1 C05619[c] + 1 coa[c] + 1 atp[c] <-> 1 C12203[c] + 1 amp[c] + 1 ppi[c]
R07437[c]	1 C05608[c] + 1 nadph[c] + 1 h[c] <-> 1 C02646[c] + 1 nadp[c]
R07443[c]	1 C12205[c] <-> 1 C15807[c]
#Retinol Metabolism
RDH11	1 retinol[c] + 1 nad[c] <-> 1 retinal[c] + 1 nadh[c] + 1 h[c]
#Aromatic degredation
R02231[c]	1 C00414[c] + 1 o2[c] + 1 nadph[c] + 1 h[c] <-> 1 C01880[c] + 1 nadp[c] + 1 h2o[c]
MUCCY_kt1	1 4cml[c] <-> 1 CCbuttc[c]
4CMLCL_kt1	1 4cml[c] -> 1 5odhf2a[c] + 1 co2[c]
#Benzoate Degradation
R03308[c]	1 C04553[c] <-> 1 CCbuttc[c]
#Tropane Biosynthesis
AADSACYCL1	1 thp2c[c] + 1 h2o[c] -> 1 L2aadp6sa[c]
NMPTRCOX1	1 nmptrc[c] + 1 o2[c] + 1 h[c] -> 1 1mpyr[c] + 1 h2o2[c] + 1 nh4[c]
R06740[c]	1 15dap[c] + 1 h2o[c] + 1 o2[c] <-> 1 C12455[c] + 1 nh4[c] + 1 h2o2[c]
#Flavonoid Biosynthesis
R02444[c]	1 C00509[c] + 1 akg[c] + 1 o2[c] <-> 1 C00974[c] + 1 succ[c] + 1 co2[c]
R03123[c]	1 C03648[c] + 1 nadp[c] <-> 1 C00974[c] + 1 nadph[c] + 1 h[c]
R03636[c]	1 C05906[c] + 1 nadp[c] <-> 1 C01617[c] + 1 nadph[c] + 1 h[c]
R03640[c]	1 C05631[c] + 1 akg[c] + 1 o2[c] <-> 1 C01617[c] + 1 succ[c] + 1 co2[c]
R05038[c]	1 C05909[c] + 1 nadp[c] <-> 1 C02906[c] + 1 nadph[c] + 1 h[c]
R05039[c]	1 C05911[c] + 1 akg[c] + 1 o2[c] <-> 1 C02906[c] + 1 succ[c] + 1 co2[c]
#Isoflavonoid biosynthesis
R06562[c]	1 C02920[c] + 1 nadph[c] + 1 h[c] <-> 1 C00786[c] + 1 nadp[c]
R07747[c]	1 C16226[c] + 1 nadph[c] + 1 h[c] <-> 1 C16227[c] + 1 nadp[c]
R07751[c]	1 C16226[c] + 1 nadph[c] + 1 h[c] <-> 1 C16228[c] + 1 nadp[c]
#Isoflavone Biosynthesis
R06563[c]	1 C12135[c] + 1 nadph[c] + 1 h[c] <-> 1 C10419[c] + 1 nadp[c]
#d-arginine and d-ornithine metabolism
DORNOp1	1 orn__D[c] + 1 h2o[c] + 1 o2[c] <-> 1 5a2opntn[c] + 1 nh4[c] + 1 h2o2[c]
DARGOp1	1 arg__D[c] + 1 h2o[c] + 1 o2[c] <-> 1 5g2oxpt[c] + 1 nh4[c] + 1 h2o2[c]
#cyanoamino acid metabolism
R02558[c]	1 C00844[c] + 1 h2o[c] <-> 1 C00561[c] + 1 glc__D[c]
R02985[c]	1 C00844[c] + 1 glc__D[c] <-> 1 C08325[c] + 1 h2o[c]
R10035[c]	1 C05143[c] + 1 h2o[c] <-> 1 C03742[c] + 1 C00221[c]
R10039[c]	1 C08334[c] + 1 h2o[c] <-> 1 C18796[c] + 1 C00221[c]
R10040[c]	1 C01594[c] + 1 h2o[c] <-> 1 C02659[c] + 1 C00221[c]
#phosphonate and phosphinate metabolism
R02590[c]	1 ctp[c] + 1 C06459[c] <-> 1 ppi[c] + 1 C05674[c]
#Aminoacyl-tRNA biosynthesis
METTRS1	1 atp[c] + 1 met__L[c] + 1 trnamet[c] -> 1 amp[c] + 1 ppi[c] + 1 mettrna[c]
TYRTRSm1	1 atp[c] + 1 tyr__L[c] + 1 trnatyr[c] -> 1 amp[c] + 1 ppi[c] + 1 tyrtrna[c]
R03038[c]	1 atp[c] + 1 ala__L[c] + 1 trnaala[c] <-> 1 amp[c] + 1 ppi[c] + 1 C00886[c]
ARGTRS1	1 atp[c] + 1 arg__L[c] + 1 trnaarg[c] <-> 1 amp[c] + 1 ppi[c] + 1 argtrna[c]
GLYTLm1	1 atp[c] + 1 gly[c] + 1 trnagly[c] <-> 1 amp[c] + 1 ppi[c] + 1 glytrna[c]
HISTRS1	1 atp[c] + 1 his__L[c] + 1 trnahis[c] <-> 1 amp[c] + 1 ppi[c] + 1 histrna[c]
ILETRSm1	1 atp[c] + 1 ile__L[c] + 1 trnaile[c] <-> 1 amp[c] + 1 ppi[c] + 1 iletrna[c]
LYSTRS1	1 atp[c] + 1 lys__L[c] + 1 trnalys[c] <-> 1 amp[c] + 1 ppi[c] + 1 lystrna[c]
PROTRS1	1 atp[c] + 1 pro__L[c] + 1 trnapro[c] <-> 1 amp[c] + 1 ppi[c] + 1 protrna[c]
THRTRS1	1 atp[c] + 1 thr__L[c] + 1 trnathr[c] <-> 1 amp[c] + 1 ppi[c] + 1 thrtrna[c]
TRPTRS1	1 atp[c] + 1 trp__L[c] + 1 trnatrp[c] <-> 1 amp[c] + 1 ppi[c] + 1 trptrna[c]
VALTRS1	1 atp[c] + 1 val__L[c] + 1 trnaval[c] <-> 1 amp[c] + 1 ppi[c] + 1 valtrna[c]
#Butanoate Metabolism
R02946[c]	1 C03044[c] + 1 nad[c] <-> 1 actn__R[c] + 1 nadh[c] + 1 h[c]
R02948[c]	1 alac__S[c] -> 1 actn__R[c] + 1 co2[c]
#Aminobenzoate degredation
R03024[c]	1 HC01104[c] + 1 h2o[c] -> 1 C00870[c] + 1 pi[c]
#Biosynthesis of antibiotics
ICHORT1	1 ichor[c] + 1 h2o[c] <-> 1 23ddhb[c] + 1 pyr[c]
TDPDRR1	1 dtdprmn[c] + 1 nadp[c] <-> 1 dtdp4d6dm[c] + 1 nadph[c] + 1 h[c]
LNSTLS1	1 Ssq23epx[c] <-> 1 lanost[c]
SAM24MT1	1 amet[c] + 1 zymst[c] <-> 1 ahcys[c] + 1 fecost[c]
R05639[c]	1 C05108[c] + 1 nadp[c] <-> 1 C11455[c] + 1 nadph[c] + 1 h[c]
R06590[c]	1 C12214[c] + 1 C00117[c] <-> 1 C12215[c] + 1 s7p[c]
MI3PS1	1 g6p[c] <-> 1 mi3p__D[c]
AKGDm1	1 akg[c] + 1 coa[c] + 1 nad[c] <-> 1 succoa[c] + 1 co2[c] + 1 nadh[c] + 1 h[c]
#Penicillin Biosynthesis
R03743[c]	1 C01866[c] + 1 h2o[c] <-> 1 C03806[c]
R06361[c]	1 C05557[c] + 1 accoa[c] + 1 h2o[c] <-> 1 pencil[c] + 1 coa[c] + 1 L2aadp[c]
R06363[c]	1 pencil[c] + 1 h2o[c] <-> 1 pencilca[c]
R07400[c]	1 C00916[c] + 1 h2o[c] + 1 o2[c] <-> 1 C04712[c] + 1 nh4[c] + 1 h2o2[c]
#Beta Alanine Metabolism
R03139[c]	1 C00986[c] + 1 o2[c] + 1 h2o[c] <-> 1 aproa[c] + 1 nh4[c] + 1 h2o2[c]
APAT2rm1	1 ala_B[c] + 1 akg[c] <-> 1 msa[c] + 1 glu__L[c]
#Porphyrin Metabolism
UPPDC11	1 uppg3[c] <-> 1 cpppg3[c] + 4 co2[c]
#Inositol Phosphate Metabolism
R03361[c]	1 atp[c] + 1 pail_cho[c] <-> 1 adp[c] + 1 pail4p_cho[c]
R03430[c]	1 C01272[c] + 1 h2o[c] <-> 1 C01243[c] + 1 pi[c]
RE2974G1	1 atp[c] + 1 pail3p_cho[c] <-> 1 adp[c] + 1 pail35p_cho[c]
R09827[c]	1 pail345p_cho[c] + 1 h2o[c] <-> 1 pail34p_cho[c] + 1 pi[c]
#Ether Lipid Metabolism
R04162[c]	1 C05977[c] + 1 h2o[c] <-> 1 ak2g_hs[c] + 1 pi[c]
#Vitamin B6 metabolism
OHPBAT1	1 phthr[c] + 1 akg[c] <-> 1 ohpb[c] + 1 glu__L[c]
#Linonene Degradation
R06411[c]	1 C11946[c] + 1 h2o[c] <-> 1 C11947[c]
R06412[c]	1 C11945[c] + 1 h2o[c] <-> 1 C11947[c]
#Xenobiotic Metabolism
R07013[c]	1 C14786[c] + 1 h2o[c] <-> 1 dhnpthld[c]
R07014[c]	1 C14787[c] + 1 h2o[c] <-> 1 dhnpthld[c]
R07027[c]	1 C14800[c] + 1 h2o[c] <-> 1 C14801[c]
R07071[c]	1 C14839[c] + 1 h2o[c] <-> 1 C14844[c]
R07072[c]	1 C14840[c] + 1 h2o[c] <-> 1 C14842[c]
R07082[c]	1 C14850[c] + 1 h2o[c] <-> 1 C14852[c]
R07105[c]	1 C06899[c] + 1 nadh[c] + 1 h[c] <-> 1 C07490[c] + 1 nad[c] + 1 h2o[c]
R09410[c]	1 C19586[c] + 1 h2o[c] <-> 1 C19588[c]
R09417[c]	1 C19489[c] + 1 h2o[c] <-> 1 C19490[c]
R09420[c]	1 C16453[c] + 1 nadph[c] + 1 h[c] <-> 1 C19574[c] + 1 nadp[c]
R09443[c]	1 C19604[c] + 1 h2o[c] <-> 1 C19607[c]
#Lipoic Acid Metabolism
R07767[c]	1 C16236[c] + 2 C17023[c] + 2 amet[c] -> 1 C16237[c] + 2 met__L[c] + 2 dad_5[c]
R07768[c]	1 C05752[c] + 2 C17023[c] + 2 amet[c] -> 1 C16239[c] + 2 met__L[c] + 2 dad_5[c]
R07769[c]	1 C16239[c] + 1 C16240[c] -> 1 C16237[c] + 1 ACP[c]
LIPATPT1	1 atp[c] + 1 C16241[c] -> 1 ppi[c] + 1 CE5656[c]
R07771[c]	1 CE5656[c] + 1 C16240[c] -> 1 C16237[c] + 1 amp[c]
R11143[c]	1 atp[c] + 1 C16241[c] + 1 C16240[c] -> 1 C16237[c] + 1 amp[c] + 1 ppi[c]
#Linolenic Acid Metabolism
R07889[c]	1 C16329[c] <-> 1 C16328[c] + 1 h2o[c]
R07893[c]	1 C16333[c] <-> 1 C16332[c] + 1 h2o[c]
R10783[c]	1 C16310[c] + 1 nadh[c] + 1 h[c] <-> 1 C08492[c] + 1 nad[c]
#Glutathione Metabolism
GTHPe1	2 gthrd[im] + 1 h2o2[im] <-> 1 gthox[im] + 2 h2o[im]
#Glutathione Metabolism
R08363[c]	1 C04232[c] + 1 C16664[c] + 1 h2o[c] <-> 1 C03723[c] + 1 C16663[c]
R08364[c]	1 C04232[c] + 1 C03170[c] + 1 h2o[c] <-> 1 C03723[c] + 1 C02090[c]
#Cutin Wax Biosynthesis
R09474[c]	1 C02843[c] <-> 1 C01629[c]
#2 Oxocarboxylic Acid
R10052[c]	1 3c2hmp[c] + 1 nad[c] -> 1 4mop[c] + 1 co2[c] + 1 nadh[c] + 1 h[c]
#Biotin Metabolism
R10116[c]	1 C20372[c] + 1 nadph[c] + 1 h[c] <-> 1 hgmeACP[c] + 1 nadp[c]
R10120[c]	1 C20376[c] + 1 nadph[c] + 1 h[c] <-> 1 hpmeACP[c] + 1 nadp[c]
#C5-branched dibasic acid metabolism
ITCOALm1	1 atp[c] + 1 itacon[c] + 1 coa[c] -> 1 adp[c] + 1 pi[c] + 1 itaccoa[c]
#Geraniol degradation
R08091[c]	1 C16466[c] + 1 coa[c] <-> 1 C16470[c] + 1 accoa[c]
#Miscellaneous cytosolic reactions
PYRDC1	1 h[c] + 1 pyr[c] -> 1 acald[c] + 1 co2[c]
R10948[c]	1 atp[c] + 1 hco3[c] -> 1 adp[c] + 1 C20969[c]
R10949[c]	1 nh4[c] + 1 C20969[c] -> 1 cbm[c] + 1 pi[c]
R10056[c]	1 C05545[c] + 2 akg[c] + 2 o2[c] -> 1 pcollglys[c] + 2 succ[c] + 2 fald[c] + 2 co2[c]
R04358[c]	1 atp[c] + 1 C03959[c] -> 1 adp[c] + 1 C04395[c]
R09644[c]	1 C19776[c] + 1 h2o[c] <-> 1 pa_EC[c] + 1 pi[c]
PPA21	1 pppi[c] + 1 h2o[c] <-> 1 ppi[c] + 1 pi[c]
PPAm1	1 ppi[c] + 1 h2o[c] -> 2 pi[c]
CCP1	1 h2o2[c] + 2 focytcc553[c] <-> 2 ficytC[c] + 2 h2o[c]
R00129[c]	1 atp[c] + 1 C04856[c] -> 1 adp[c] + 1 pi[c] + 1 nadh[c]
BPNT1	1 pap[c] + 1 h2o[c] -> 1 amp[c] + 1 pi[c]
R00275[c]	2 o2s[c] + 2 h[c] <-> 1 h2o2[c] + 1 o2[c]
PYK41	1 cdp[c] + 1 pep[c] -> 1 ctp[c] + 1 pyr[c]
PYK21	1 udp[c] + 1 pep[c] -> 1 utp[c] + 1 pyr[c]
R00767[c]	1 ctp[c] + 1 C00085[c] -> 1 cdp[c] + 1 fdp[c]
R00769[c]	1 utp[c] + 1 C00085[c] -> 1 udp[c] + 1 fdp[c]
G6PDH2r1	1 g6p[c] + 1 nadp[c] -> 1 6pgl[c] + 1 nadph[c] + 1 h[c]
TRE6PS1	1 udpg[c] + 1 g6p[c] -> 1 udp[c] + 1 tre6p[c]
R01289[c]	1 ser__L[c] + 1 hcys__L[c] -> 1 C00542[c] + 1 h2o[c]
R01493[c]	1 crm_cho[c] + 1 h2o[c] <-> 1 h[c] + 1 Rtotal[c] + 1 C00319[c]
R01532[c]	1 C00201[c] + 1 h2o[c] -> 1 C00215[c] + 1 ppi[c]
R01654[c]	1 atp[c] + 1 10fthf[c] + 1 glu__L[c] <-> 1 adp[c] + 1 pi[c] + 1 C05928[c]
PFK_31	1 atp[c] + 1 s7p[c] <-> 1 adp[c] + 1 s17bp[c]
R01853[c]	1 C00375[c] + 1 h2o[c] + 1 o2[c] <-> 1 C00071[c] + 1 nh4[c] + 1 h2o2[c]
R01963[c]	1 C01075[c] + 1 h2o[c] <-> 1 gam[c] + 1 so4[c]
HIBDm1	1 3hmp[c] + 1 nad[c] <-> 1 2mop[c] + 1 nadh[c] + 1 h[c]
R02113[c]	1 udpg[c] + 1 C00370[c] <-> 1 udp[c] + 1 C03641[c]
CSNATm1	1 accoa[c] + 1 C00487[c] <-> 1 coa[c] + 1 acrn[c]
R02418[c]	1 C04090[c] + 1 h2o[c] <-> 1 C00496[c] + 1 C00145[c]
R02508[c]	1 C00542[c] + 1 succ[c] <-> 1 suchms[c] + 1 cys__L[c]
R02584[c]	1 atp[c] + 1 C00585[c] -> 1 adp[c] + 1 C01167[c]
R02585[c]	1 C01167[c] + 1 h2o[c] -> 1 C00585[c] + 1 pi[c]
R02715[c]	1 Dara14lac[c] + 1 o2[c] <-> 1 C06316[c] + 1 h2o2[c]
R02767[c]	1 3haACP[c] + 1 nadp[c] <-> 1 C00685[c] + 1 nadph[c] + 1 h[c]
PSP_D1	1 pser__D[c] + 1 h2o[c] <-> 1 ser__D[c] + 1 pi[c]
R02878[c]	1 C00756[c] + 1 nad[c] <-> 1 octal[c] + 1 nadh[c] + 1 h[c]
R02884[c]	1 atp[c] + 1 C00759[c] <-> 1 adp[c] + 1 C01022[c]
R02984[c]	1 dtdpglu[c] <-> 1 C02097[c]
R03054[c]	1 C00903[c] + 1 nadph[c] + 1 h[c] <-> 1 C02394[c] + 1 nadp[c]
R03120[c]	1 C01021[c] + 1 akg[c] <-> 1 C00972[c] + 1 glu__L[c]
R03259[c]	1 C04212[c] + 1 h2o[c] <-> 1 C01117[c]
R03352[c]	1 C04047[c] + 1 h2o[c] <-> 1 3hmp[c] + 1 coa[c]
R03357[c]	1 C04036[c] + 1 nadp[c] <-> 1 C01192[c] + 1 nadph[c] + 1 h[c]
R03410[c]	1 amet[c] + 1 C01229[c] <-> 1 ahcys[c] + 1 C04215[c]
R03446[c]	1 C01253[c] + 1 h2o[c] <-> 1 C03315[c] + 1 adprib[c]
R03449[c]	1 atp[c] + 1 C01256[c] <-> 1 adp[c] + 1 C01293[c]
R03492[c]	1 ga2_cho[c] + 1 h2o[c] <-> 1 C01290[c] + 1 acgal[c]
R03532[c]	1 nad[c] + 1 h2o2[c] <-> 1 nadh[c] + 2 h2o[c]
R03546[c]	1 cynt[c] + 1 h[c] + 1 hco3[c] -> 1 co2[c] + 1 cbm[c]
R03552[c]	1 accoa[c] + 1 C02415[c] <-> 1 coa[c] + 1 C01997[c]
SELTORc1	1 slnt[c] + 6 fdxrd[c] + 8 h[c] -> 1 seln[c] + 6 fdxox[c] + 3 h2o[c]
R03632[c]	1 atp[c] + 1 C01609[c] <-> 1 adp[c] + 1 C02729[c]
R03681[c]	1 udpg[c] + 1 C01702[c] <-> 1 udp[c] + 1 C02687[c]
R03760[c]	1 accoa[c] + 1 C15534[c] <-> 1 coa[c] + 1 C15535[c]
R03789[c]	1 C01977[c] + 1 C01449[c] <-> 1 C01978[c] + 1 gua[c]
R03828[c]	1 gtp[c] + 1 C02100[c] <-> 1 ppi[c] + 1 C02031[c]
R03840[c]	1 atp[c] + 1 C02374[c] <-> 1 adp[c] + 1 C02128[c]
R03854[c]	1 C02623[c] + 1 pyr[c] <-> 1 C02146[c] + 1 co2[c] + 1 ala__L[c]
R03938[c]	1 amet[c] + 1 C02415[c] <-> 1 ahcys[c] + 1 C03702[c]
GLPT1	1 tdcoa[c] + 1 glp[c] <-> 1 coa[c] + 1 tglp[c]
R04023[c]	1 atp[c] + 1 C02707[c] <-> 1 adp[c] + 1 C03874[c]
DGC3D1	1 2dglcn[c] + 1 nad[c] <-> 1 3ddgc[c] + 1 nadh[c] + 1 h[c]
R04058[c]	1 C02986[c] <-> 1 C02805[c] + 1 nh4[c]
R04072[c]	1 dolmanp[c] + 1 C02189[c] <-> 1 C00110[c] + 1 C02863[c]
R04090[c]	1 C03899[c] + 1 h2o[c] <-> 1 gthrd[c] + 1 C02929[c]
R04100[c]	1 C02944[c] <-> 1 dd2coa[c]
R04176[c]	1 nad[c] <-> 1 ncam[c] + 1 C03245[c] + 1 h[c]
R04184[c]	1 thcrm_cho[c] + 1 acgal[c] <-> 1 gbside_cho[c] + 1 h2o[c]
R04190[c]	1 amet[c] + 1 C03306[c] <-> 1 ahcys[c] + 1 C04311[c]
R04216[c]	1 C04213[c] + 1 C03021[c] <-> 1 doldp[c] + 1 C11572[c]
R04273[c]	1 C03798[c] <-> 1 C03633[c]
R04294[c]	1 C04232[c] + 1 trdox[c] + 1 h2o[c] <-> 1 C03723[c] + 1 trdrd[c]
R04314[c]	1 C04250[c] + 1 C02743[c] <-> 1 C03800[c] + 1 C11475[c]
R04316[c]	1 accoa[c] + 1 C03803[c] <-> 1 coa[c] + 1 C04341[c]
R04318[c]	1 C16672[c] <-> 1 peng[c] + 1 h2o[c]
R04437[c]	1 C07282[c] + 1 nad[c] + 1 o2[c] <-> 1 C04679[c] + 1 nadh[c] + 1 h2o[c]
R04482[c]	1 C05364[c] <-> 1 C04324[c]
GLCNACT_cho1	1 uacgam[c] + 1 naglc2p[c] <-> 1 udp[c] + 1 chito2pdol[c]
R04586[c]	1 C04884[c] + 1 h2o[c] <-> 1 C04730[c] + 1 acgal[c]
R04671[c]	1 C05110[c] <-> 1 C05111[c]
R04805[c]	1 C05444[c] + 1 nad[c] <-> 1 C05445[c] + 1 nadh[c] + 1 h[c]
R04868[c]	1 C05557[c] + 1 phaccoa[c] + 1 h2o[c] <-> 1 peng[c] + 1 L2aadp[c] + 1 coa[c]
R04928[c]	1 atp[c] + 1 C05686[c] <-> 1 adp[c] + 1 C05696[c]
SELCYSTS1	1 ser__L[c] + 1 selhcys[c] <-> 1 selcyst[c] + 1 h2o[c]
R04945[c]	1 achms[c] + 1 selcys[c] <-> 1 selcyst[c] + 1 ac[c]
R04949[c]	1 C05713[c] + 1 h2o[c] <-> 1 C05712[c] + 1 glc__D[c]
CYTP450R1	1 cytP450o[c] + 1 nadph[c] <-> 1 cytP450r[c] + 1 nadp[c] + 1 h[c]
R05197[c]	1 atp[c] + 1 C05928[c] + 1 glu__L[c] <-> 1 adp[c] + 1 pi[c] + 1 C05929[c]
R05334[c]	1 nmptrc[c] + 1 o2[c] + 1 h2o[c] <-> 1 C10974[c] + 1 h2o2[c] + 1 nh4[c]
R05595[c]	1 b2coa[c] + 1 h2o[c] <-> 1 C05116[c]
R05722[c]	1 C02060[c] + 1 akg[c] + 1 o2[c] <-> 1 C07343[c] + 1 succ[c] + 1 co2[c]
R05755[c]	3 h[c] + 1 amet[c] + 1 aso3[c] <-> 1 ahcys[c] + 1 C07294[c]
ACONMT1	1 amet[c] + 1 acon_T[c] -> 1 ahcys[c] + 1 aconm[c]
R05782[c]	1 C11529[c] + 1 h2o[c] <-> 1 C00151[c] + 1 nh4[c] + 1 co2[c]
DALAOX1	1 ala__D[c] + 1 h2o[c] + 1 o2[c] <-> 1 pyr[c] + 1 nh4[c] + 1 h2o2[c]
R06134[c]	1 C00241[c] + 1 h2o[c] <-> 1 h[c] + 1 Rtotal[c] + 1 nh4[c]
MAOX1	1 mma[c] + 1 o2[c] + 1 h2o[c] <-> 1 fald[c] + 1 nh4[c] + 1 h2o2[c]
R06861[c]	1 xu5p__D[c] + 1 thmpp[c] <-> 1 C13378[c] + 1 g3p[c]
R06863[c]	1 s7p[c] + 1 thmpp[c] <-> 1 C13378[c] + 1 C00117[c]
R07140[c]	1 hmgth[c] + 1 nadp[c] -> 1 Sfglutth[c] + 1 nadph[c] + 1 h[c]
R07285[c]	1 C00066[c] + 1 pi[c] <-> 1 C00454[c]
R07314[c]	1 3hacoa[c] <-> 1 C05067[c] + 1 h2o[c]
CBMD1	1 cbm[c] <-> 1 nh4[c] + 1 co2[c]
R07329[c]	1 C02099[c] + 1 akg[c] + 1 o2[c] <-> 1 C21417[c] + 1 succ[c] + 1 co2[c]
R07330[c]	1 amet[c] + 1 C15571[c] <-> 1 ahcys[c] + 1 C15572[c]
R07360[c]	1 C06751[c] + 1 o2[c] + 1 h2o[c] <-> 1 C15604[c] + 1 cys__L[c] + 1 h2o2[c]
R07627[c]	1 C16014[c] + 1 h2o[c] <-> 1 C16015[c]
R08539[c]	1 nadph[c] + 2 ficytb5[c] -> 1 h[c] + 1 nadp[c] + 2 focytb5[c]
R08551[c]	1 C03161[c] + 1 nadph[c] + 1 h[c] <-> 1 C03024[c] + 1 nadp[c]
R08575[c]	1 s7p[c] + 1 g3p[c] <-> 1 e4p[c] + 1 C00085[c]
R08602[c]	1 C17202[c] + 1 h2o[c] <-> 1 hdca[c] + 1 C02743[c]
R08707[c]	1 C04375[c] + 1 h2o[c] <-> 1 C01239[c] + 1 C02871[c]
R09381[c]	1 C00173[c] + 1 1ag3p_SC[c] <-> 1 ACP[c] + 1 pa_EC[c]
CYNTAH1	1 cynt[c] + 1 hco3[c] + 1 h[c] -> 1 nh4[c] + 2 co2[c]
R10092[c]	1 hco3[c] + 1 h[c] <-> 1 co2[c] + 1 h2o[c]
R10159[c]	2 adfdRD[c] + 1 nadp[c] + 1 h[c] <-> 2 C00667[c] + 1 nadph[c]
R10209[c]	1 C01977[c] + 1 preq1[c] <-> 1 C20446[c] + 1 gua[c]
R10267[c]	1 adp[c] + 1 C04856[c] <-> 1 amp[c] + 1 pi[c] + 1 nadh[c]
R10268[c]	1 adp[c] + 1 C04899[c] <-> 1 amp[c] + 1 pi[c] + 1 nadph[c]
R10484[c]	1 pmtcoa[c] + 1 C02743[c] <-> 1 C17202[c] + 1 coa[c]
R10813[c]	1 C00201[c] <-> 1 C20864[c] + 1 ppi[c]
R10845[c]	1 C20895[c] + 1 akg[c] <-> 1 C20646[c] + 1 glu__L[c]
R10951[c]	1 atp[c] + 1 pail_cho[c] <-> 1 adp[c] + 1 pail5p_cho[c]
R10953[c]	1 atp[c] + 1 C01272[c] <-> 1 adp[c] + 1 C01284[c]
R11231[c]	1 thp2c[c] + 1 nad[c] + 2 h2o[c] -> 1 L2aadp[c] + 1 nadh[c] + 1 h[c]
R11232[c]	1 thp2c[c] + 1 nadp[c] + 2 h2o[c] -> 1 L2aadp[c] + 1 nadph[c] + 1 h[c]
R11399[c]	1 dolmanp[c] + 1 C19803[c] <-> 1 C00110[c] + 1 C20722[c]
R11500[c]	1 C21418[c] + 1 nadp[c] <-> 1 C21417[c] + 1 nadph[c] + 1 h[c]
R00157[c]	1 utp[c] + 1 amp[c] <-> 1 udp[c] + 1 adp[c]
R00390[c]	1 atp[c] + 1 C00347[c] + 1 coa[c] -> 1 amp[c] + 1 ppi[c] + 1 accoa[c]
R00381[c]	1 atp[c] + 1 C02128[c] -> 1 amp[c] + 1 ppi[c]
R00900[c]	1 h[c] + 1 cys__L[c] + 1 gthrd[c] + 1 nadp[c] <-> 1 C05526[c] + 1 nadph[c]
R11104[c]	1 nadh[c] + 1 h2o[c] <-> 1 amp[c] + 1 C21113[c]
ACPh1	1 13dpg[c] + 1 h2o[c] -> 1 3pg[c] + 1 pi[c]
R02515[c]	1 3hoxpac[c] + 1 o2[c] + 1 nadh[c] + 1 h[c] -> 1 hgentis[c] + 1 nad[c] + 1 h2o[c]
R04672[c]	1 alac__S[c] + 1 thmpp[c] <-> 1 2ahethmpp[c] + 1 pyr[c]
SELCYSTGL1	1 selcyst[c] + 1 h2o[c] -> 1 selcys[c] + 1 nh4[c] + 1 2obut[c]
R03225[c]	1 C03197[c] + 1 akg[c] <-> 1 acac[c] + 1 C01087[c]
FORCT1	1 forcoa[c] + 1 oxa[c] <-> 1 for[c] + 1 oxalcoa[c]
#aminoacyl-tRNA biosynthesis
GLNTRAT1	1 glntrna[im] + 1 glu__L[im] + 1 pi[im] + 1 adp[im] <-> 1 glutrna_gln[im] + 1 gln__L[im] + 1 atp[im] + 1 h2o[im]
TRPTRS1	1 atp[im] + 1 trp__L[im] + 1 trnatrp[im] <-> 1 amp[im] + 1 ppi[im] + 1 trptrna[im]
#cyanoamino acid metabolism
R07638[im]	1 C16075[im] <-> 1 C16074[im] + 1 h2o[im]
#Lipoic Acid Metabolism
R07769[im]	1 C16239[im] + 1 C16240[im] -> 1 C16237[im] + 1 ACP[im]
R07766[im]	1 C05752[im] + 1 C16240[im] -> 1 C16236[im] + 1 ACP[im]
#Linolenic Acid Metabolism
R07899[im]	1 C16339[im] + 1 accoa[im] <-> 1 coa[im] + 1 C16338[im]
R07055[im]	1 lnlc[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14825[im] + 1 nadp[im] + 1 h2o[im]
R07056[im]	1 lnlc[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14826[im] + 1 nadp[im] + 1 h2o[im]
#Arginine Biosynthesis
ASPTA1	1 asp__L[im] + 1 akg[im] -> 1 oaa[im] + 1 glu__L[im]
ALATA_L1	1 ala__L[im] + 1 akg[im] -> 1 pyr[im] + 1 glu__L[im]
R09107[im]	1 C15532[im] + 1 h2o[im] <-> 1 ac[im] + 1 citr__L[im]
ACOTA1	1 acorn[im] + 1 akg[im] <-> 1 acg5sa[im] + 1 glu__L[im]
#Glycine, serine, and threonine metabolism
SERD_L1	1 ser__L[im] -> 1 pyr[im] + 1 nh4[im]
R00945[im]	1 mlthf[im] + 1 gly[im] + 1 h2o[im] <-> 1 thf[im] + 1 ser__L[im]
#Histidine metabolism
R00254[im]	1 glu__L[im] + 1 nh4[im] + 1 co2[im] <-> 1 C05829[im] + 1 h2o[im]
#Alanine, Aspartate, Glutamine metabolism
ASNS21	1 atp[im] + 1 asp__L[im] + 1 nh4[im] -> 1 amp[im] + 1 ppi[im] + 1 asn__L[im]
#pyrimidine metabolism
NDPK4m1	1 atp[im] + 1 dtdp[im] -> 1 adp[im] + 1 dttp[im]
CTPS11	1 atp[im] + 1 utp[im] + 1 nh4[im] -> 1 adp[im] + 1 pi[im] + 1 ctp[im]
URIK21	1 gtp[im] + 1 uri[im] -> 1 gdp[im] + 1 ump[im]
DGTCY1	1 dgtp[c] + 1 cytd[c] -> 1 dgdp[c] + 1 cmp[c]
#Microbial metabolism in diverse environments
PDH1	1 coa[im] + 1 nad[im] + 1 pyr[im] -> 1 accoa[im] + 1 co2[im] + 1 nadh[im]
ALCD2x1	1 acald[im] + 1 nadh[im] + 1 h[im] <- 1 etoh[im] + 1 nad[im]
R02989[im]	1 3oxoadp[im] + 1 nadp[im] -> 1 C02222[im] + 1 nadph[im] + 1 h[im]
R02988[im]	1 3oxoadp[im] + 1 nad[im] -> 1 C02222[im] + 1 nadh[im] + 1 h[im]
R05259[im]	1 C06604[im] + 1 C03024[im] + 1 o2[im] <-> 1 C06606[im] + 1 C03161[im] + 1 s[im] + 1 h2o[im]
R05358[im]	1 C01998[im] + 2 h2o[im] <-> 1 acryl[im] + 1 nh4[im]
R05506[im]	1 C07118[im] + 1 coa[im] -> 1 benzcoa[im] + 1 accoa[im]
OGCOAAT1	1 3opimcoa[im] + 1 coa[im] -> 1 glutcoa[im] + 1 accoa[im]
R01067[im]	1 C00085[im] + 1 g3p[im] <-> 1 e4p[im] + 1 xu5p__D[im]
R07939[im]	1 C07481[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C13747[im] + 1 nadp[im] + 1 fald[im] + 1 h2o[im]
#Purine Metabolism
ADK1m1	1 atp[im] + 1 amp[im] -> 2 adp[im]
IMPD1	1 imp[im] + 1 nad[im] + 1 h2o[im] -> 1 xmp[im] + 1 nadh[im] + 1 h[im]
#CoA biosynthesis
R01226[im]	1 mlthf[im] + 1 3mob[im] + 1 h2o[im] -> 1 thf[im] + 1 2dhp[im]
#Glyoxylate and dicarboxylate metabolism
R01221[im]	1 gly[im] + 1 thf[im] + 1 nad[im] -> 1 mlthf[im] + 1 nh4[im] + 1 co2[im] + 1 nadh[im] + 1 h[im]
#Xenobiotic Metabolism
R07021[im]	1 C14040[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14802[im] + 1 nadp[im] + 1 h2o[im]
R07022[im]	1 C14040[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14800[im] + 1 nadp[im] + 1 h2o[im]
R07000[im]	1 C00829[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14786[im] + 1 nadp[im] + 1 h2o[im]
R07001[im]	1 C00829[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14787[im] + 1 nadp[im] + 1 h2o[im]
R07085[im]	1 C14852[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14853[im] + 1 nadp[im] + 1 h2o[im]
R07087[im]	1 C14556[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14854[im] + 1 nadp[im] + 1 h2o[im]
R07098[im]	1 C06790[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C11148[im] + 1 nadp[im] + 1 h2o[im]
R07099[im]	1 C06790[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14866[im] + 1 nadp[im] + 1 h2o[im]
R07079[im]	1 C07535[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14849[im] + 1 nadp[im] + 1 h2o[im]
R07080[im]	1 C07535[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14850[im] + 1 nadp[im] + 1 h2o[im]
R07081[im]	1 C07535[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 C14851[im] + 1 nadp[im] + 1 h2o[im]
R09404[im]	1 C06800[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19585[im] + 1 h2o[im] + 1 nadp[im]
R09405[im]	1 C06800[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C16756[im] + 1 h2o[im] + 1 nadp[im]
R09406[im]	1 C16756[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19594[im] + 1 h2o[im] + 1 nadp[im]
R09407[im]	1 C06800[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19595[im] + 1 h2o[im] + 1 nadp[im]
R09408[im]	1 C06800[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19586[im] + 1 h2o[im] + 1 nadp[im]
R09418[im]	1 C19490[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19559[im] + 1 h2o[im] + 1 nadp[im]
R09416[im]	1 CN0020[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19489[im] + 1 h2o[im] + 1 nadp[im]
R09421[im]	1 C16453[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19563[im] + 1 h2o[im] + 1 nadp[im]
R09423[im]	1 C16453[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19566[im] + 1 h2o[im] + 1 nadp[im]
R09424[im]	1 C19574[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19577[im] + 1 h2o[im] + 1 nadp[im]
R09425[im]	1 C19574[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19580[im] + 1 h2o[im] + 1 nadp[im]
R09442[im]	1 CN0020[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C19604[im] + 1 h2o[im] + 1 nadp[im]
#Valine, Leucine, and Isoleucine degredation
VALTA1	1 val__L[im] + 1 akg[im] <-> 1 3mob[im] + 1 glu__L[im]
AACOAT1	1 atp[im] + 1 acac[im] + 1 coa[im] -> 1 amp[im] + 1 ppi[im] + 1 aacoa[im]
#Valine, Leucine, and Isoleucine synthesis
R04441[im]	1 23dhmb[im] -> 1 3mob[im] + 1 h2o[im]
R05071[im]	1 alac__S[im] <-> 1 3hmoa[im]
#Ubiquinone metabolism
R07235[im]	1 amet[im] + 1 C03226[im] <-> 1 ahcys[im] + 1 C01967[im]
3DH5HPBMTm1	1 amet[im] + 1 3dh5hpb[im] <-> 1 ahcys[im] + 1 3hph5mb[im]
R04983[im]	1 C05803[im] + 1 amet[im] <-> 1 C05804[im] + 1 ahcys[im]
URFGTT1	1 2ombz[im] + 1 amet[im] <-> 1 2ommb[im] + 1 ahcys[im]
R02175[im]	1 C05805[im] + 1 amet[im] <-> 1 q6[im] + 1 ahcys[im]
#Folate synthesis 
R04241[im]	1 atp[im] + 1 glu__L[im] <-> 1 adp[im] + 1 pi[im] + 1 C03541[im]
DHFS1	1 atp[im] + 1 dhpt[im] + 1 glu__L[im] -> 1 adp[im] + 1 pi[im] + 1 dhf[im]
#Terpenoid synthesis
MEVK1x1	1 atp[im] + 1 mev__R[im] <-> 1 adp[im] + 1 5pmev[im]
#Steroid hormone synthesis
R03408[im]	1 dhea[im] + 1 h[im] + 1 o2[im] + 1 nadph[im] <-> 1 C05139[im] + 1 nadp[im] + 1 h2o[im]
R03088[im]	1 estradiol[im] + 1 h[im] + 1 o2[im] + 1 nadh[im] -> 1 C05301[im] + 1 nad[im] + 1 h2o[im]
R03089[im]	1 estradiol[im] + 1 h[im] + 1 o2[im] + 1 nadph[im] <-> 1 estriol[im] + 1 nadp[im] + 1 h2o[im]
RE3013R1	1 estradiol[im] + 1 h[im] + 1 o2[im] + 1 nadph[im] -> 1 C05301[im] + 1 nadp[im] + 1 h2o[im]
RE1630R1	1 C05298[im] + 1 amet[im] <-> 1 C05299[im] + 1 ahcys[im]
RE2386C1	1 C05301[im] + 1 amet[im] <-> 1 C05302[im] + 1 ahcys[im]
R02354[im]	1 estrone[im] + 1 h[im] + 1 o2[im] + 1 nadh[im] -> 1 C05298[im] + 1 nad[im] + 1 h2o[im]
RE1587C1	1 estrone[im] + 1 h[im] + 1 o2[im] + 1 nadph[im] -> 1 C05298[im] + 1 nadp[im] + 1 h2o[im]
RE2235C1	1 estrone[im] + 1 h[im] + 1 o2[im] + 1 nadph[im] <-> 1 C05300[im] + 1 nadp[im] + 1 h2o[im]
R02503[im]	1 C00535[im] + 1 C03024[im] + 1 o2[im] <-> 1 C05291[im] + 1 C03161[im] + 1 h2o[im]
#Lysine degredation
BBHOX1	1 gbbtn[im] + 1 akg[im] + 1 o2[im] <-> 1 C00487[im] + 1 succ[im] + 1 co2[im]
#Steroid biosynthesis
R03689[im]	1 lanost[im] + 1 nadph[im] + 1 h[im] <-> 1 C05109[im] + 1 nadp[im]
R07507[im]	1 C05107[im] + 1 nadph[im] + 1 h[im] <-> 1 C01164[im] + 1 nadp[im]
ZYMSTR1	1 zymst[im] + 1 nadph[im] + 1 h[im] <-> 1 zymstnl[im] + 1 nadp[im]
R07499[im]	1 C05108[im] + 1 nadph[im] + 1 h[im] <-> 1 CE2314[im] + 1 nadp[im]
#C5 dibase acid synthesis
ITCOALm1	1 atp[im] + 1 itacon[im] + 1 coa[im] -> 1 adp[im] + 1 pi[im] + 1 itaccoa[im]
#Tyrosine metabolism
R03304[im]	1 amet[im] + 1 34dhpacet[im] <-> 1 ahcys[im] + 1 C05582[im]
R04887[im]	1 amet[im] + 1 C05580[im] <-> 1 ahcys[im] + 1 C05584[im]
R04881[im]	1 amet[im] + 1 34dhoxpeg[im] <-> 1 ahcys[im] + 1 C05594[im]
SALMCOM1	1 amet[im] + 1 nrpphr[im] <-> 1 ahcys[im] + 1 normete__L[im]
#Tryptophane metabolism
R03936[im]	1 Lfmkynr[im] + 1 h2o[im] <-> 1 C05653[im] + 1 ala__L[im]
R03629[im]	1 C01598[im] + 1 C03024[im] + 1 o2[im] <-> 1 C05643[im] + 1 C03161[im] + 1 h2o[im]
R04909[im]	1 5hxkynam[im] + 1 co2[im] <-> 1 C05651[im]
HKYNH1	1 hLkynr[im] + 1 h2o[im] <-> 1 3hanthrn[im] + 1 ala__L[im]
#Synthesis of antibiotics
R06590[im]	1 C12214[im] + 1 C00117[im] <-> 1 C12215[im] + 1 s7p[im]
G5SD1	1 glu5sa[im] + 1 pi[im] + 1 nadp[im] <-> 1 glu5p[im] + 1 nadph[im] + 1 h[im]
AKGDm1	1 akg[im] + 1 coa[im] + 1 nad[im] -> 1 succoa[im] + 1 co2[im] + 1 nadh[im] + 1 h[im]
#Retinol Metabolism
R08390[im]	1 retn[im] + 1 nadph[im] + 1 h[im] + 1 o2[im] <-> 1 C16679[im] + 1 nadp[im] + 1 h2o[im]
R08391[im]	1 retn[im] + 1 nadph[im] + 1 h[im] + 1 o2[im] <-> 1 CE2953[im] + 1 nadp[im] + 1 h2o[im]
R08392[im]	1 retn[im] + 1 nadph[im] + 1 h[im] + 1 o2[im] <-> 1 C16677[im] + 1 nadp[im] + 1 h2o[im]
#Drug metabolism - cytochrome P450
R03697[im]	1 C01516[im] + 1 C03161[im] + 1 fald[im] + 1 h2o[im] <-> 1 C06174[im] + 1 C03024[im] + 1 o2[im]
R08312[im]	1 C06868[im] + 1 nadph[im] + 1 h[im] + 1 o2[im] <-> 1 C07496[im] + 1 nadp[im] + 1 h2o[im]
R08343[im]	1 C07572[im] <-> 1 dmcital[im]
R08344[im]	1 C07572[im] <-> 1 citalo[im]
R08345[im]	1 dmcital[im] <-> 1 ddmcital[im]
R08286[im]	1 C07047[im] <-> 1 C16550[im] + 1 C06754[im]
R08287[im]	1 C07047[im] <-> 1 C16555[im] + 1 C06754[im]
R08293[im]	1 lido[im] <-> 1 meglyxyl[im]
LIDOMO1	1 lido[im] + 1 nadph[im] + 1 o2[im] + 1 h[im] <-> 1 3hlido[im] + 1 nadp[im] + 1 h2o[im]
R08265[im]	1 C01516[im] + 1 C03024[im] + 1 o2[im] <-> 1 C11785[im] + 1 fald[im] + 1 C03161[im] + 1 h2o[im]
#Hypotaurin emetabolism
TAUDO1	1 taur[im] + 1 akg[im] + 1 o2[im] <-> 1 so3[im] + 1 aacald[im] + 1 succ[im] + 1 co2[im]
#Butanoate Metabolism
R02946[im]	1 C03044[im] + 1 nad[im] <-> 1 actn__R[im] + 1 nadh[im] + 1 h[im]
#Inositol phosphate metabolism
R03361[im]	1 atp[im] + 1 pail_cho[im] <-> 1 adp[im] + 1 pail4p_cho[im]
#Arachidonic acid metabolism
R07041[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14748[im] + 1 nadp[im] + 1 h2o[im]
R07042[im]	1 C05966[im] <-> 1 C14781[im]
R07043[im]	1 C05966[im] <-> 1 C14813[im]
R07044[im]	1 C14781[im] + 1 h2o[im] <-> 1 C14782[im]
R07045[im]	1 C14813[im] + 1 h2o[im] <-> 1 C14814[im]
R07046[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14749[im] + 1 nadp[im] + 1 h2o[im]
R07048[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14771[im] + 1 nadp[im] + 1 h2o[im]
R07050[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14770[im] + 1 nadp[im] + 1 h2o[im]
R07051[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14769[im] + 1 nadp[im] + 1 h2o[im]
R07052[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14768[im] + 1 nadp[im] + 1 h2o[im]
R07054[im]	1 C00219[im] + 1 o2[im] + 1 nadph[im] + 1 h[im] <-> 1 C14778[im] + 1 nadp[im] + 1 h2o[im]
#Cysteine and methionine metabolism
MTRI1	1 5mdr1p[im] <-> 1 5mdru1p[im]
ARD_11	1 dhmtp[im] + 1 o2[im] <-> 1 2kmb[im] + 1 for[im]
#Glycolysis
PDCh1	1 2ahethmpp[im] -> 1 acald[im] + 1 thmpp[im]
#Miscellaneous mitochondrial reactions
R03222[im]	3 o2[im] + 1 pppg9[im] -> 3 h2o[im] + 1 ppp9[im]
CCP1	2 focytcc553[im] + 1 h2o2[im] -> 2 ficytC[im] + 2 h2o[im]
R01209[im]	1 C04039[im] -> 1 3mob[im] + 1 h2o[im]
R03051[im]	1 C00900[im] + 1 nadph[im] + 1 h[im] -> 1 C04039[im] + 1 nadp[im]
R00157[im]	1 utp[im] + 1 amp[im] <-> 1 udp[im] + 1 adp[im]
PPAm1	1 ppi[im] + 1 h2o[im] <-> 1 pi[im]
R00081[im]	1 o2[im] + 4 focytcc553[im] + 4 h[im] -> 4 ficytC[im] + 2 h2o[im]
R00057[im]	1 o2[im] + 2 C01525[im] <-> 1 C02318[im] + 1 h2o2[im]
R00381[im]	1 atp[im] + 1 C02128[im] -> 1 amp[im] + 1 ppi[im]
R00390[im]	1 atp[im] + 1 C00347[im] + 1 coa[im] -> 1 amp[im] + 1 ppi[im] + 1 accoa[im]
R00597[im]	1 amet[im] + 1 C01977[im] <-> 1 ahcys[im] + 1 C04157[im]
R00827[im]	1 amet[im] + 1 catechol[im] <-> 1 ahcys[im] + 1 C01502[im]
2DHPFALDL1	1 2dhp[im] <-> 1 3mob[im] + 1 fald[im]
R09737[im]	1 amet[im] + 1 C19858[im] <-> 1 ahcys[im] + 1 C19859[im]
R10092[im]	1 hco3[im] + 1 h[im] <-> 1 co2[im] + 1 h2o[im]
R10159[im]	2 adfdRD[im] + 1 nadp[im] + 1 h[im] <-> 2 C00667[im] + 1 nadph[im]
R10288[im]	1 atp[im] + 1 C04899[im] <-> 1 adp[im] + 1 pi[im] + 1 nadph[im]
R10648[im]	1 C20641[im] + 1 C17324[im] <-> 1 amp[im] + 1 C20751[im]
R10845[im]	1 C20895[im] + 1 akg[im] <-> 1 C20646[im] + 1 glu__L[im]
TRDR1	1 trdrd[im] + 1 nadp[im] <-> 1 trdox[im] + 1 nadph[im] + 1 h[im]
R01654[im]	1 atp[im] + 1 10fthf[im] + 1 glu__L[im] <-> 1 adp[im] + 1 pi[im] + 1 C05928[im]
ACPh1	1 13dpg[im] + 1 h2o[im] <-> 1 3pg[im] + 1 pi[im]
R02161[im]	1 C00390[im] + 2 ficytC[im] -> 1 C00399[im] + 2 focytcc553[im] + 2 h[im]
R02163[im]	1 C00390[im] + 1 nad[im] -> 1 C00399[im] + 1 nadh[im] + 1 h[im]
R02807[im]	1 C01319[im] + 1 nadp[im] + 1 h[im] <-> 1 hg2[im] + 1 nadph[im]
R07606[im]	1 met__L[im] + 1 trdox[im] + 1 h2o[im] <-> 1 C15999[im] + 1 trdrd[im]
R06134[im]	1 C00241[im] + 1 h2o[im] <-> 1 h[im] + 1 Rtotal[im] + 1 nh4[im]
R05197[im]	1 atp[im] + 1 C05928[im] + 1 glu__L[im] <-> 1 adp[im] + 1 pi[im] + 1 C05929[im]
R05190[im]	1 accoa[im] + 1 malcoa[im] + 2 nadph[im] + 4 h[im] <-> 1 C02843[im] + 1 coa[im] + 1 co2[im] + 2 nadp[im] + 1 h2o[im]
R04673[im]	1 2obut[im] + 1 2ahethmpp[im] <-> 1 2ahbut[im] + 1 thmpp[im]
R04672[im]	1 alac__S[im] + 1 thmpp[im] <-> 1 2ahethmpp[im] + 1 pyr[im]
R04710[im]	1 h[im] + 1 amet[im] + 1 C05196[im] + 1 C05197[im] <-> 1 dad_5[im] + 1 met__L[im] + 1 C05199[im] + 1 C05312[im]
R03449[im]	1 atp[im] + 1 C01256[im] <-> 1 adp[im] + 1 C01293[im]
SELTORc1	1 slnt[im] + 6 fdxrd[im] + 8 h[im] -> 1 seln[im] + 6 fdxox[im] + 3 h2o[im]
R02879[im]	1 C01387[im] + 2 rbrdxRD[im] + 1 o2[im] + 2 h[im] <-> 1 C00756[im] + 2 rbrdxOX[im] + 1 h2o[im]
R03050[im]	1 2ahethmpp[im] + 1 pyr[im] -> 1 C00900[im] + 1 thmpp[im]
R07330[im]	1 amet[im] + 1 C15571[im] <-> 1 ahcys[im] + 1 C15572[im]
FORCT1	1 forcoa[im] + 1 oxa[im] <-> 1 for[im] + 1 oxalcoa[im]
R04433[im]	1 C04570[im] + 1 C00399[im] <-> 1 C04253[im] + 1 C00390[im]
R04439[im]	1 23dhmb[im] + 1 nadp[im] <-> 1 alac__S[im] + 1 nadph[im] + 1 h[im]
R04120[im]	1 C03023[im] + 1 trdox[im] + 1 h2o[im] <-> 1 C03895[im] + 1 trdrd[im]
R04122[im]	2 h[im] + 1 C03024[im] + 1 C01371[im] + 1 o2[im] <-> 1 C03161[im] + 1 C01335[im] + 1 h2o[im]
#Galactose metabolism 
SUCRe1	1 sucr[e] + 1 h2o[e] -> 1 fru[e] + 1 glc__D[e]
R10619[e]	1 gal[e] <-> 1 C00984[e]
GALS41	1 stys[e] + 1 h2o[e] <-> 1 raffin[e] + 1 gal[e]
MELTGH1	1 melt[e] + 1 h2o[e] <-> 1 sbt__D[e] + 1 gal[e]
LCGH1	1 lcts[e] + 1 h2o[e] <-> 1 glc__aD[e] + 1 gal[e]
EPMGH1	1 epm[e] + 1 h2o[e] <-> 1 man[e] + 1 gal[e]
GALIGH1	1 1Dgali[e] + 1 h2o[e] <-> 1 inost[e] + 1 gal[e]
DGGH1	1 6dg[e] + 1 h2o[e] <-> 1 gal[e] + 1 glc__D[e]
RGH1	1 raffin[e] + 1 h2o[e] <-> 1 gal[e] + 1 sucr[e]
#Sphingolipid metabolism
R04019[e]	1 digalside_cho[e] + 1 h2o[e] <-> 1 C02686[e] + 1 gal[e]
R03355[e]	1 C01290[e] + 1 h2o[e] <-> 1 gluside_cho[e] + 1 gal[e]
#Inositol Phosphate metabolism
R03371[e]	1 minohp[e] + 1 h2o[e] <-> 1 C04563[e] + 1 pi[e]
#Tyrosine metabolism
TYROXDApp1	1 tym[e] + 1 h2o[e] + 1 o2[e] <-> 1 4hoxpacd[e] + 1 nh4[e] + 1 h2o2[e]
#Aminosugar metabolism
R02333[e]	1 chtn[e] + 1 h2o[e] <-> 1 C00734[e] + 1 ac[e]
#Lipoic Acid Metabolism
R07766[e]	1 C05752[e] + 1 C16240[e] -> 1 C16236[e] + 1 ACP[e]
R07606[e]	1 met__L[e] + 1 trdox[e] + 1 h2o[e] <-> 1 C15999[e] + 1 trdrd[e]
R07769[e]	1 C16239[e] + 1 C16240[e] -> 1 C16237[e] + 1 ACP[e]
#Microbial metabolism in diverse environments
R07827[e]	1 C05618[e] + 1 o2[e] <-> 1 C16266[e]
#Miscellaneous extracellular reactions
R04120[e]	1 C03895[e] + 1 trdrd[e] -> 1 C03023[e] + 1 trdox[e] + 1 h2o[e]
R10092[e]	1 hco3[e] + 1 h[e] <-> 1 co2[e] + 1 h2o[e]
R03618[e]	1 thcrm_cho[e] + 1 h2o[e] <-> 1 gal[e] + 1 C01290[e]
R03411[e]	1 amet[e] + 1 C01229[e] -> 1 ahcys[e] + 1 C04340[e]
R03115[e]	1 C00965[e] + 1 h2o[e] <-> 1 glc__aD[e]
R02857[e]	1 C16487[e] + 1 glyclt[e] -> 1 C06108[e] + 1 h2o[e]
R02336[e]	1 C01812[e] + 1 h2o[e] <-> 1 glyclt[e] + 1 C00462[e]
R01853[e]	1 C00375[e] + 1 h2o[e] + 1 o2[e] <-> 1 C00071[e] + 1 nh4[e] + 1 h2o2[e]
LACZ1	1 lcts[e] + 1 h2o[e] -> 1 glc__D[e] + 1 gal[e]
ALKP1	1 dhap[e] + 1 h2o[e] -> 1 dha[e] + 1 pi[e]
MAOX1	1 mma[e] + 1 o2[e] + 1 h2o[e] <-> 1 fald[e] + 1 nh4[e] + 1 h2o2[e]
R05334[e]	1 nmptrc[e] + 1 o2[e] + 1 h2o[e] <-> 1 C10974[e] + 1 h2o2[e] + 1 nh4[e]
#Transport reactions
R400t	1 C04253[c] <- 1 C04253[om]
R401t	1 C04253[om] <- 1 C04253[im]
R402t	1 C04570[im] <- 1 C04570[om]
R403t	1 C04570[om] <- 1 C04570[c]
R001t	1 ac[e] -> 1 ac[c]
R002t	1 glc__D[e] -> 1 glc__D[c]
R005t	1 lys__L[e] -> 1 lys__L[c]
R003t	1 mal__L[c] + 1 2oxoadp[om] <-> 1 mal__L[om] + 1 2oxoadp[c]
R004t	1 mal__L[om] + 1 2oxoadp[im] <-> 1 mal__L[im] + 1 2oxoadp[om]
R013t	1 adp[c] + 1 atp[om] -> 1 adp[om] + 1 atp[c]
R014t	1 adp[om] + 1 atp[im] -> 1 adp[im] + 1 atp[om]
R015t	1 akg[c] + 1 cit[om] <-> 1 akg[om] + 1 cit[c]
R016t	1 akg[om] + 1 cit[im] <-> 1 akg[im] + 1 cit[om]
R020t	1 asp__L[om] + 1 glu__L[c] <-> 1 asp__L[c] + 1 glu__L[om]
R021t	1 asp__L[im] + 1 glu__L[om] <-> 1 asp__L[om] + 1 glu__L[im]
R023t	1 mal__L[om] + 1 cit[c] <-> 1 mal__L[c] + 1 cit[om]
R024t	1 mal__L[im] + 1 cit[om] <-> 1 mal__L[om] + 1 cit[im]
R025t	1 cit[c] + 1 pep[om] <-> 1 cit[om] + 1 pep[c]
R026t	1 cit[om] + 1 pep[im] <-> 1 cit[im] + 1 pep[om]
R027t	1 cit[c] + 1 icit[om] <-> 1 cit[om] + 1 icit[c]
R028t	1 cit[om] + 1 icit[im] <-> 1 cit[im] + 1 icit[om]
R029t	1 coa[c] <-> 1 coa[om]
R030t	1 coa[om] <-> 1 coa[im]
R031t	1 cmp[om] + 1 ctp[c] + 1 h[c] <-> 1 cmp[c] + 1 ctp[om] + 1 h[om]
R032t	1 cmp[im] + 1 ctp[om] + 1 h[om] <-> 1 cmp[om] + 1 ctp[im] + 1 h[im]
R038t	1 lac__D[c] + 1 h[c] <-> 1 lac__D[om] + 1 h[om]
R039t	1 lac__D[om] + 1 h[om] <-> 1 lac__D[im] + 1 h[im]
R040t	1 man[e] + 1 h[e] <-> 1 man[c] + 1 h[c]
R045t	1 fadh2[om] <-> 1 fadh2[c]
R046t	1 fadh2[im] <-> 1 fadh2[om]
R074t	1 lac__L[c] <-> 1 lac__L[om]
R075t	1 lac__L[om] <-> 1 lac__L[im]
R079t	1 h[e] + 1 met__L[e] <-> 1 h[c] + 1 met__L[c]
R082t	1 h[e] + 1 ser__L[e] <-> 1 h[c] + 1 ser__L[c]
R088t	1 mal__L[c] + 1 pi[om] <-> 1 mal__L[om] + 1 pi[c]
R089t	1 mal__L[om] + 1 pi[im] <-> 1 mal__L[im] + 1 pi[om]
R090t	1 h[e] + 1 malt[e] <-> 1 h[c] + 1 malt[c]
R095t	1 amp[om] + 1 nad[c] <-> 1 amp[c] + 1 nad[om]
R096t	1 amp[im] + 1 nad[om] <-> 1 amp[om] + 1 nad[im]
R097t	1 dgmp[om] + 1 nad[c] <-> 1 dgmp[c] + 1 nad[om]
R098t	1 dgmp[im] + 1 nad[om] <-> 1 dgmp[om] + 1 nad[im]
R100t	1 h[c] + 1 C01602[om] <-> 1 h[om] + 1 C01602[c]
R101t	1 h[om] + 1 C01602[im] <-> 1 h[im] + 1 C01602[om]
R103t	1 h[c] + 1 oaa[c] <-> 1 h[om] + 1 oaa[om]
R104t	1 h[om] + 1 oaa[om] <-> 1 h[im] + 1 oaa[im]
R106t	1 pendp[c] <-> 1 pendp[om]
R107t	1 pendp[om] <-> 1 pendp[im]
R109t	1 h[e] + 1 pi[e] <-> 1 h[c] + 1 pi[c]
R110t	1 h[c] + 1 pi[c] -> 1 h[om] + 1 pi[om]
R111t	1 h[om] + 1 pi[om] -> 1 h[im] + 1 pi[im]
R115t	1 h[e] + 1 amet[e] <-> 1 h[c] + 1 amet[c]
R116t	1 amet[c] <-> 1 amet[om]
R117t	1 amet[om] <-> 1 amet[im]
R120t	1 pi[om] + 1 succ[c] <-> 1 pi[c] + 1 succ[om]
R121t	1 pi[im] + 1 succ[om] <-> 1 pi[om] + 1 succ[im]
R122t	1 fum[om] + 1 succ[c] <-> 1 fum[c] + 1 succ[om]
R123t	1 fum[im] + 1 succ[om] <-> 1 fum[om] + 1 succ[im]
R126t	1 dtdp[c] <-> 1 dtdp[om]
R127t	1 dtdp[om] <-> 1 dtdp[im]
R132t	1 fmn[om] + 1 h[c] + 1 ump[om] + 1 utp[c] <-> 1 fmn[c] + 1 h[om] + 1 ump[c] + 1 utp[om]
R133t	1 fmn[im] + 1 h[om] + 1 ump[im] + 1 utp[om] <-> 1 fmn[om] + 1 h[im] + 1 ump[om] + 1 utp[im]
R134t	1 C00965[e] <-> 1 C00965[c]
R136t	1 2dhp[c] <-> 1 2dhp[om]
R137t	1 2dhp[om] <-> 1 2dhp[im]
R139t	1 3c3hmp[c] <-> 1 3c3hmp[om]
R140t	1 3c3hmp[om] <-> 1 3c3hmp[im]
R142t	1 2mbald[c] <-> 1 2mbald[om]
R143t	1 2mbald[om] <-> 1 2mbald[im]
R144t	1 2obut[c] <-> 1 2obut[om]
R145t	1 2obut[om] <-> 1 2obut[im]
R147t	1 2phetoh[e] <-> 1 2phetoh[c]
R148t	1 2phetoh[om] <-> 1 2phetoh[c]
R149t	1 2phetoh[im] <-> 1 2phetoh[om]
R150t	1 3c4mop[c] <-> 1 3c4mop[om]
R151t	1 3c4mop[om] <-> 1 3c4mop[im]
R152t	1 3mop[c] <-> 1 3mop[om]
R153t	1 3mop[om] <-> 1 3mop[im]
R157t	1 3ophb_5[c] <-> 1 3ophb_5[om]
R158t	1 3ophb_5[om] <-> 1 3ophb_5[im]
R159t	1 4abz[c] <-> 1 4abz[e]
R160t	1 4abz[c] <-> 1 4abz[om]
R161t	1 4abz[om] <-> 1 4abz[im]
R162t	1 4abutn[c] <-> 1 4abutn[om]
R163t	1 4abutn[om] <-> 1 4abutn[im]
R164t	1 4abut[c] <-> 1 4abut[om]
R165t	1 4abut[om] <-> 1 4abut[im]
R166t	1 4h2oglt[c] <-> 1 4h2oglt[om]
R167t	1 4h2oglt[om] <-> 1 4h2oglt[im]
R168t	1 4hbz[c] <-> 1 4hbz[om]
R169t	1 4hbz[om] <-> 1 4hbz[im]
R170t	1 5aop[c] <-> 1 5aop[om]
R171t	1 5aop[om] <-> 1 5aop[im]
R172t	1 dann[e] <-> 1 dann[c]
R173t	1 acald[om] <-> 1 acald[c]
R174t	1 acald[im] <-> 1 acald[om]
R175t	1 acald[e] <-> 1 acald[c]
R176t	1 ade[c] <-> 1 ade[om]
R177t	1 ade[om] <-> 1 ade[im]
R181t	1 h[c] + 1 arg__L[c] <-> 1 h[om] + 1 arg__L[om]
R182t	1 h[om] + 1 arg__L[om] <-> 1 h[im] + 1 arg__L[im]
R183t	1 h[e] + 1 gln__L[e] <-> 1 h[c] + 1 gln__L[c]
R184t	1 asn__L[c] <-> 1 asn__L[om]
R185t	1 asn__L[om] <-> 1 asn__L[im]
R189t	1 co2[c] -> 1 co2[e]
R190t	1 co2[om] -> 1 co2[c]
R191t	1 co2[im] -> 1 co2[om]
R194t	1 e4p[c] <-> 1 e4p[om]
R195t	1 e4p[om] <-> 1 e4p[im]
R203t	1 dhnpt[c] <-> 1 dhnpt[om]
R204t	1 dhnpt[om] <-> 1 dhnpt[im]
R205t	1 dhf[c] <-> 1 dhf[om]
R206t	1 dhf[om] <-> 1 dhf[im]
R207t	1 dhpt[c] <-> 1 dhpt[om]
R208t	1 dhpt[om] <-> 1 dhpt[im]
R209t	1 dhap[om] <-> 1 dhap[c]
R210t	1 dhap[im] <-> 1 dhap[om]
R211t	1 C00110[c] <-> 1 C00110[e]
R212t	1 ergtetrol[c] <-> 1 ergtetrol[e]
R214t	1 etoh[c] <-> 1 etoh[e]
R215t	1 etoh[c] <-> 1 etoh[om]
R216t	1 etoh[om] <-> 1 etoh[im]
R220t	1 for[om] <-> 1 for[c]
R221t	1 for[im] <-> 1 for[om]
R224t	1 gly[c] <-> 1 gly[om]
R225t	1 gly[om] <-> 1 gly[im]
R226t	1 gcald[c] <-> 1 gcald[om]
R227t	1 gcald[om] <-> 1 gcald[im]
R228t	1 gcald[e] <-> 1 gcald[c]
R230t	1 gua[c] <-> 1 gua[om]
R231t	1 gua[om] <-> 1 gua[im]
R232t	1 gsn[c] <-> 1 gsn[om]
R233t	1 gsn[om] <-> 1 gsn[im]
R234t	1 gsn[e] <-> 1 gsn[c]
R236t	1 C08362[e] <-> 1 C08362[c]
R237t	1 his__L[c] <-> 1 his__L[om]
R238t	1 his__L[om] <-> 1 his__L[im]
R239t	1 C00356[c] <-> 1 C00356[om]
R240t	1 C00356[om] <-> 1 C00356[im]
R241t	1 hxan[e] <-> 1 hxan[c]
R242t	1 id3acald[c] <-> 1 id3acald[om]
R243t	1 id3acald[om] <-> 1 id3acald[im]
R244t	1 id3acald[c] <-> 1 id3acald[e]
R245t	1 ind3ac[c] <-> 1 ind3ac[om]
R246t	1 ind3ac[om] <-> 1 ind3ac[im]
R247t	1 ins[e] <-> 1 ins[c]
R248t	1 ibutoh[c] <-> 1 ibutoh[e]
R249t	1 ibutoh[c] <-> 1 ibutoh[om]
R250t	1 ibutoh[om] <-> 1 ibutoh[im]
R251t	1 ala__L[om] <-> 1 ala__L[c]
R252t	1 ala__L[im] <-> 1 ala__L[om]
R255t	1 crn[om] <-> 1 crn[c]
R256t	1 crn[im] <-> 1 crn[om]
R258t	1 ile__L[om] <-> 1 ile__L[c]
R259t	1 ile__L[im] <-> 1 ile__L[om]
R261t	1 pro__L[c] <-> 1 pro__L[om]
R262t	1 pro__L[om] <-> 1 pro__L[im]
R266t	1 lys__L[c] <-> 1 lys__L[om]
R267t	1 lys__L[om] <-> 1 lys__L[im]
R268t	1 C00464[c] <-> 1 C00464[e]
R269t	1 met__L[om] <-> 1 met__L[c]
R270t	1 met__L[im] <-> 1 met__L[om]
R275t	1 nmn[e] <-> 1 nmn[c]
R276t	1 acrn[c] <-> 1 acrn[om]
R277t	1 acrn[om] <-> 1 acrn[im]
R278t	1 o2[e] -> 1 o2[c]
R279t	1 o2[c] -> 1 o2[om]
R280t	1 o2[om] -> 1 o2[im]
R282t	1 oaa[c] <-> 1 oaa[e]
R283t	1 pmtcoa[c] <-> 1 pmtcoa[e]
R284t	1 pan4p[c] <-> 1 pan4p[om]
R285t	1 pan4p[om] <-> 1 pan4p[im]
R286t	1 pacald[c] <-> 1 pacald[e]
R287t	1 pacald[c] <-> 1 pacald[om]
R288t	1 pacald[om] <-> 1 pacald[im]
R289t	1 phe__L[c] <-> 1 phe__L[om]
R290t	1 phe__L[om] <-> 1 phe__L[im]
R291t	1 pppg9[c] <-> 1 pppg9[om]
R292t	1 pppg9[om] <-> 1 pppg9[im]
R293t	1 prpp[c] <-> 1 prpp[om]
R294t	1 prpp[om] <-> 1 prpp[im]
R295t	1 ppi[c] <-> 1 ppi[om]
R296t	1 ppi[om] <-> 1 ppi[im]
R297t	1 h[c] + 1 pyr[c] <-> 1 h[om] + 1 pyr[om]
R298t	1 h[om] + 1 pyr[om] <-> 1 h[im] + 1 pyr[im]
R299t	1 quln[c] <-> 1 quln[om]
R300t	1 quln[om] <-> 1 quln[im]
R305t	1 ahcys[c] <-> 1 ahcys[om]
R306t	1 ahcys[om] <-> 1 ahcys[im]
R307t	1 ser__L[c] <-> 1 ser__L[om]
R308t	1 ser__L[om] <-> 1 ser__L[im]
R313t	1 thr__L[c] <-> 1 thr__L[om]
R314t	1 thr__L[om] <-> 1 thr__L[im]
R316t	1 h[c] + 1 tre[c] <-> 1 h[e] + 1 tre[e]
R317t	1 trp__L[c] <-> 1 trp__L[om]
R318t	1 trp__L[om] <-> 1 trp__L[im]
R319t	1 ind3eth[c] <-> 1 ind3eth[e]
R320t	1 ind3eth[c] <-> 1 ind3eth[om]
R321t	1 ind3eth[om] <-> 1 ind3eth[im]
R322t	1 tyr__L[c] <-> 1 tyr__L[om]
R323t	1 tyr__L[om] <-> 1 tyr__L[im]
R324t	1 val__L[c] <-> 1 val__L[om]
R325t	1 val__L[om] <-> 1 val__L[im]
R339t	1 h2o[e] <-> 1 h2o[c]
R340t	1 h2o[c] <-> 1 h2o[om]
R341t	1 h2o[om] <-> 1 h2o[im]
R343t	1 nh4[e] <-> 1 nh4[c]
R344t	1 nh4[c] -> 1 nh4[om]
R345t	1 nh4[om] -> 1 nh4[im]
R346t	1 sucr[e] <-> 1 sucr[c]
R347t	1 C01356[im] <-> 1 C01356[om]
R348t	1 C01356[om] <-> 1 C01356[c]
R349t	1 ocdce9coa[c] <-> 1 ocdce9coa[om]
R350t	1 ocdce9coa[om] <-> 1 ocdce9coa[im]
R351t	1 strcoa[im] <-> 1 strcoa[om]
R352t	1 strcoa[om] <-> 1 strcoa[c]
R353t	1 so4[e] <-> 1 so4[c]
R354t	1 cytd[c] <-> 1 cytd[om]
R355t	1 cytd[om] <-> 1 cytd[im]
R356t	1 dutp[c] <-> 1 dutp[om]
R357t	1 dutp[om] <-> 1 dutp[im]
R358t	1 focytb5[c] <-> 1 focytb5[om]
R359t	1 focytb5[om] <-> 1 focytb5[im]
R360t	1 dctp[c] <-> 1 dctp[om]
R361t	1 dctp[om] <-> 1 dctp[im]
R362t	1 dadp[c] <-> 1 dadp[om]
R363t	1 dadp[om] <-> 1 dadp[im]
R364t	1 X00001[c] <-> 1 X00001[e]
R365t	1 fad[om] -> 1 fad[c]
R366t	1 fad[im] -> C00016[om]
R369t	1 h2s[c] <-> 1 h2s[om]
R370t	1 h2s[om] <-> 1 h2s[im]
R371t	1 selmeth[c] -> 1 selmeth[om]
R372t	1 selmeth[om] -> 1 selmeth[im]
R373t	1 C05689[c] -> 1 C05689[om]
R374t	1 C05689[om] -> 1 C05689[im]
R375t	1 seln[c] <-> 1 seln[om]
R376t	1 seln[om] <-> 1 seln[im]
R377t	1 glyc[e] <-> 1 glyc[c]
R378t	1 udp[e] <-> 1 udp[c]
R379t	1 glyc3p[im] -> 1 glyc3p[om]
R380t	1 glyc3p[om] -> 1 glyc3p[c]
R382t	1 X00002[c] -> 1 X00002[e]
R383t	1 ficytb5[im] -> 1 ficytb5[om]
R384t	1 ficytb5[om] -> 1 ficytb5[c]
R385t	1 dttp[c] <-> 1 dttp[om]
R386t	1 dttp[om] <-> 1 dttp[im]
R387t	1 acgam[c] -> 1 acgam[e]
R388t	1 C01356[c] -> 1 C01356[e]
R389t	1 C00355[c] -> 1 C00355[e]
R390t	1 C00017[c] -> 1 C00017[e]
R391t	1 acgam[c] -> 1 acgam[e]
R392t	1 chtn[c] -> 1 chtn[e]
R399t	1 hom__L[e] <-> 1 hom__L[c]
R502t	1 urate[c] -> 1 urate[e]
#added from first round of OptFill
R01697[c]	1 sbt__D[c] + 1 nadp[c] <-> 1 srb__L[c] + 1 nadph[c] + 1 h[c]
SORD_D1	1 sbt__D[c] + 1 fad[c] <- 1 fadh2[c] + 1 srb__L[c]
ALDD2y1	1 acald[im] + 1 nadp[im] + 1 h2o[im] <-> 1 ac[im] + 1 nadph[im] + 1 h[im]
METOX1	1 met__L[c] + 1 h2o[c] + 1 o2[c] <-> 1 2kmb[c] + 1 nh4[c] + 1 h2o2[c]
METOX1	1 met__L[im] + 1 h2o[im] + 1 o2[im] <-> 1 2kmb[im] + 1 nh4[im] + 1 h2o2[im]
ILEOX1	1 ile__L[im] + 1 h2o[im] + 1 o2[im] <-> 1 3mop[im] + 1 nh4[im] + 1 h2o2[im]
R01915[c]	1 spmd[c] + 1 nadp[c] + 1 h2o[c] <-> 1 C00986[c] + 1 4abutn[c] + 1 nadph[c] + 1 h[c]
R00946[c]	1 5mthf[c] + 1 hcys__L[c] <-> 1 thf[c] + 1 met__L[c]
R02111[c]	1 starch[c] + 1 pi[c] <-> 1 C00718[c] + 1 g1p[c]
AHSERL21	1 achms[c] + 1 h2s[c] <-> 1 hcys__L[c] + 1 ac[c]
CYSS_trdrd1	1 acser[c] + 1 tsul[c] + 1 trdrd[c] + 1 h[c] <-> 1 cys__L[c] + 1 so3[c] + 1 trdox[c] + 1 ac[c]
ARAT1	1 2kmb[im] + 1 glu__L[im] <-> 1 met__L[im] + 1 akg[im]
R03469[c]	1 atp[c] + 1 pail4p_cho[c] <-> 1 adp[c] + 1 pail45p_cho[c]
INSK1	1 atp[c] + 1 ins[c] <-> 1 adp[c] + 1 imp[c]
R01321[c]	1 cdpchol[c] + 1 C00641[c] <-> 1 cmp[c] + 1 pchol_cho[c]
R03115[c]	1 C00965[c] + 1 h2o[c] <-> 1 glc__aD[c]
R00944[c]	1 10fthf[c] + 1 h2o[c] <-> 1 for[c] + 1 thf[c]
NDP31	1 gdp[c] + 1 h2o[c] <-> 1 gmp[c] + 1 pi[c]
SUCOAS1m1	1 gtp[im] + 1 succ[im] + 1 coa[im] <-> 1 gdp[im] + 1 pi[im] + 1 succoa[im]
ITCOAL1m1	1 gtp[im] + 1 itacon[im] + 1 coa[im] <-> 1 gdp[im] + 1 pi[im] + 1 itaccoa[im]
#added from second round of OptFill
R05576[c]	1 C05116[c] + 1 nadp[c] <-> 1 aacoa[c] + 1 nadph[c] + 1 h[c]
R09375[c]	1 25drapp[c] + 1 nadh[c] + 1 h[c] <-> 1 C18910[c] + 1 nad[c]
R01352[c]	1 C02112[c] + 1 h2o[c] <-> 1 glyc[c] + 1 C00162[c]
#added from third round of optfill
R00625[c]	1 C00226[c] + 1 nadp[c] <- 1 C00071[c] + 1 nadph[c] + 1 h[c]
R01093[c]	1 gal[c] + 1 nadh[c] + 1 h[c] <-> 1 galt[c] + 1 nad[c]
R01758[c]	1 abt__L[c] + 1 nad[c] <-> 1 C00259[c] + 1 nadh[c] + 1 h[c]
GALOR1	1 gal[c] + 1 nadph[c] + 1 h[c] -> 1 galt[c] + 1 nadp[c]
XYLR1	1 xylt[c] + 1 nadp[c] <-> 1 xyl__D[c] + 1 nadph[c] + 1 h[c]
R01759[c]	1 abt__L[c] + 1 nadp[c] <- 1 C00259[c] + 1 nadph[c] + 1 h[c]
R09477[c]	1 xylt[c] + 1 nad[c] -> 1 xyl__D[c] + 1 nadh[c] + 1 h[c]
ALDD19xr1	1 pacald[c] + 1 nad[c] + 1 h2o[c] -> 1 C07086[c] + 1 nadh[c] + 1 h[c]
R02695[c]	1 4hoxpacd[c] + 1 nad[c] + 1 h2o[c] -> 1 4hoxpac[c] + 1 nadh[c] + 1 h[c]
34DHALDD1	1 34dhpac[c] + 1 nad[c] + 1 h2o[c] -> 1 34dhpacet[c] + 1 nadh[c] + 1 h[c]
r05481	1 pacald[c] + 1 nadp[c] + 1 h2o[c] <-> 1 C07086[c] + 1 nadph[c] + 1 h[c]
R02697[c]	1 4hoxpacd[c] + 1 nadp[c] + 1 h2o[c] <-> 1 4hoxpac[c] + 1 nadph[c] + 1 h[c]
R04883[c]	1 34dhmald[c] + 1 nadp[c] + 1 h2o[c] <- 1 C05580[c] + 1 nadph[c] + 1 h[c]
R02989[c]	1 3oxoadp[c] + 1 nadp[c] <-> 1 C02222[c] + 1 nadph[c] + 1 h[c]
R04096[c]	1 ivcoa[c] + 1 C04253[c] <-> 1 3mb2coa[c] + 1 C04570[c]
MBCOAi1	1 ivcoa[c] + 1 fad[c] <-> 1 3mb2coa[c] + 1 fadh2[c]
R09077[c]	1 spmd[c] + 1 o2[c] + 1 h2o[c] <-> 1 ptrc[c] + 1 aproa[c] + 1 h2o2[c]
2DHPFALDL1	1 2dhp[c] <-> 1 3mob[c] + 1 fald[c]
R09380[c]	1 C00173[c] + 1 glyc3p[c] -> 1 1ag3p_SC[c] + 1 ACP[c]
PTRCTA1	1 ptrc[c] + 1 akg[c] <- 1 4abutn[c] + 1 glu__L[c]
#added to try to fix C07330[c], C04489[c], 1 C04144[c]
rxn11944[c]	1 ahcys[c] + 1 h[c] + 1 mhpglu[c] <-> 1 amet[c] + 1 hpglu[c]
R05708[c]	1 C04083[c] + 1 h2o[c] + 1 nadp[c] <-> 1 ade[c] + 1 C07330[c] + 1 nadph[c] + 1 h[c]
R08072[c]	1 C16427[c] + 1 h2o[c] <-> 1 C04083[c] + 1 rib__D[c]
R08069[c]	1 C04713[c] + 1 h2o[c] <-> 1 C16427[c] + 1 pi[c]
R04038[c]	1 dmpp[c] + 1 amp[c] <-> 1 ppi[c] + 1 C04713[c]
#added to try to fix CoA synthesis having irregular shadow cost with some precursors having positive shadow cost
#this first block is reactions related to the hydrolysis of energy molecules
NTP51	1 ctp[c] + 1 h2o[c] -> 1 cdp[c] + 1 pi[c]
ATPM1	1 atp[c] + 1 h2o[c] -> 1 adp[c] + 1 pi[c]
NTP3pp1	1 gtp[c] + 1 h2o[c] -> 1 gdp[c] + 1 pi[c]
NTP91	1 dttp[c] + 1 h2o[c] -> 1 dtdp[c] + 1 pi[c]
NDP8ex1	1 utp[c] + 1 h2o[c] -> 1 udp[c] + 1 pi[c]
CDPPH1	1 cdp[c] + 1 h2o[c] -> 1 cmp[c] + 1 pi[c]
NDP11	1 adp[c] + 1 h2o[c] -> 1 amp[c] + 1 pi[c]
DTPH1	1 dtdp[c] + 1 h2o[c] -> 1 dtmp[c] + 1 pi[c]
NDP71	1 udp[c] + 1 h2o[c] -> 1 ump[c] + 1 pi[c]
R00113[c]	1 h2o2[c] + 1 nadph[c] + 1 h[c] -> 1 nadp[c] + 2 h2o[c]
NADHPO1	1 h2o2[c] + 1 nadh[c] + 1 h[c] -> 1 nad[c] + 2 h2o[c]
FADRx1	1 fadh2[c] + 1 nad[c] -> 1 fad[c] + 1 nadh[c] + 1 h[c]
FNOR1	2 fdxox[c] + 1 nadph[c] -> 2 fdxrd[c] + 1 nadp[c] + 1 h[c]
NDP61	1 dcdp[c] + 1 h2o[c] -> 1 dcmp[c] + 1 pi[c]
R02163[c]	1 C00390[c] + 1 nad[c] -> 1 C00399[c] + 1 nadh[c] + 1 h[c]
R00936[c]	1 thf[c] + 1 nad[c] -> 1 dhf[c] + 1 nadh[c] + 1 h[c]
#This block is related to taurine and hypotaurine metabolism, which appears to be essential when
#creating output metabolites for getting rid of excess/waste nitrogen and/or sulfur
#these first two reactions were already present, but relocated here during curation
R02466[c]	1 3sala[c] <-> 1 C00519[c] + 1 co2[c]
TAUDO1	1 taur[c] + 1 akg[c] + 1 o2[c] <-> 1 so3[c] + 1 aacald[c] + 1 succ[c] + 1 co2[c]
#these reactions were not yet present in the model
R02434[c]	1 Lcyst[c] + 1 nadh[c] + 1 h[c] <- 1 3sala[c] + 1 h2o[c] + 1 nad[c]
LCYSTCBOXL1	1 Lcyst[c] -> 1 taur[c] + 1 co2[c]
R10984[c]	1 ser__L[c] + 1 nadp[c] <-> 1 aacald[c] + 1 co2[c] + 1 nadph[c] + 1 h[c]
R02474[c]	1 pnto__R[c] + 1 h2o[c] -> 1 pant__R[c] + 1 ala_B[c]
APNPT1	1 pan4p[c] + 1 adp[c] -> 1 atp[c] + 1 ptth[c]
PNTEH1	1 ptth[c] + 1 h2o[c] -> 1 pnto__R[c] + 1 cysam[c]
R02467[c]	1 cysam[c] + 1 o2[c] -> 1 C00519[c]
R01685[c]	1 taur[c] + 1 h2o[c] + 2 ficytC[c] <-> 1 2saa[c] + 1 nh4[c] + 2 focytcc553[c] + 2 h[c]
R05651[c]	1 2saa[c] + 1 pi[c] <-> 1 actp[c] + 1 so3[c]
COAHLp1	1 coa[c] + 1 h2o[c] -> 1 pan4p[c] + 1 pap[c]
R09379[c]	1 atp[c] + 1 C18911[c] + 1 ala_B[c] <- 1 amp[c] + 1 ppi[c] + 1 4ppan[c]
DHPM11	1 56dura[c] + 1 h2o[c] <- 1 cala[c]
UPPN1	1 cala[c] + 1 h2o[c] <- 1 ala_B[c] + 1 co2[c] + 1 nh4[c]
DURAD1	1 56dura[c] + 1 nadp[c] -> 1 ura[c] + 1 nadph[c] + 1 h[c]
R09378[c]	1 atp[c] + 1 pant__R[c] <- 1 adp[c] + 1 C18911[c]