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<desc>Creator: FreeHEP Graphics2D Driver Producer: org.freehep.graphicsio.svg.SVGGraphics2D Revision Source:  Date: Thursday, February 15, 2024 at 8:34:09 PM Central European Standard Time</desc>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Liver Injury</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">androstane receptor </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Immune cell activation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 363.2747497558594 567.55859375 L 413.2747497558594 567.55859375 L 413.2747497558594 617.55859375 L 363.2747497558594 617.55859375 L 363.2747497558594 567.55859375 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, NR1H4</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1935.1513671875 -1469.365478515625 L 1985.1513671875 -1469.365478515625 L 1985.1513671875 -1419.365478515625 L 1935.1513671875 -1419.365478515625 L 1935.1513671875 -1469.365478515625 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 942.1571179034295, 12.130873226049959)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (kupffer cell) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, SCD-1</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 310.85357666015625 -688.8533325195312 L 360.85357666015625 -688.8533325195312 L 360.85357666015625 -638.8533325195312 L 310.85357666015625 -638.8533325195312 L 310.85357666015625 -688.8533325195312 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 648.0315128620392, 152.87623792604393)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Accumulation, Liver lipid</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 547.4579467773438 877.0995483398438 L 597.4579467773438 877.0995483398438 L 597.4579467773438 927.0995483398438 L 547.4579467773438 927.0995483398438 L 547.4579467773438 877.0995483398438 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 686.4190403925636, 436.5345616995163)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Altered gene expression specific </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 687.1845205340497, 439.07621164004956)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">to CAR activation, Hepatocytes </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1055.3106482887051, 35.632850470412265)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Apoptotic cell death</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 235.3746337890625 535.7850952148438 L 285.3746337890625 535.7850952148438 L 285.3746337890625 585.7850952148438 L 235.3746337890625 585.7850952148438 L 235.3746337890625 535.7850952148438 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 638.6946385788242, 375.7023452746477)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, NRF2</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1964.2412109375 -1294.4005126953125 L 2014.2412109375 -1294.4005126953125 L 2014.2412109375 -1244.4005126953125 L 1964.2412109375 -1244.4005126953125 L 1964.2412109375 -1294.4005126953125 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 948.3115213808001, 41.42454820525539)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 946.5689346241719, 43.96619814578865)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (Bile duct cell) </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 259.38116455078125 -478.0910949707031 L 319.38116455078125 -478.0910949707031 L 319.38116455078125 -418.0910949707031 L 259.38116455078125 -418.0910949707031 L 259.38116455078125 -478.0910949707031 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 634.895967808807, 192.13473122253075)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Triglyceride formation</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 572.884417715619, 173.78070454754248)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, CYP1A1</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -1268.2589111328125 1569.0428466796875 L -1218.2589111328125 1569.0428466796875 L -1218.2589111328125 1619.0428466796875 L -1268.2589111328125 1619.0428466796875 L -1268.2589111328125 1569.0428466796875 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 356.0303017857309, 562.4354220540824)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Alterations, Cellular proliferation </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 366.7614164990016, 564.9770719946157)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">/ hyperplasia </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1029.2854340285219, 24.940405120138465)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial dysfunction</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 301.1750183105469 -232.3312225341797 L 361.1750183105469 -232.3312225341797 L 361.1750183105469 -172.3312225341797 L 301.1750183105469 -172.3312225341797 L 301.1750183105469 -232.3312225341797 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 642.7563376451944, 236.8513712342533)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, De Novo FA synthesis</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1969.2061767578125 -1360.9371337890625 L 2019.2061767578125 -1360.9371337890625 L 2019.2061767578125 -1310.9371337890625 L 1969.2061767578125 -1310.9371337890625 L 1969.2061767578125 -1360.9371337890625 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 950.1797558034099, 29.318039101275915)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Ballooning </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 948.2308732147794, 31.859689041809176)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">degeneration (hepatocyte) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 163.84149169921875 -619.5478515625 L 243.84149169921875 -619.5478515625 L 243.84149169921875 -539.5478515625 L 163.84149169921875 -539.5478515625 L 163.84149169921875 -619.5478515625 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 623.9209540288679, 168.2158367205721)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Accumulation, Fatty acid</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 148.11203002929688 796.6723022460938 L 198.11203002929688 796.6723022460938 L 198.11203002929688 846.6723022460938 L 148.11203002929688 846.6723022460938 L 148.11203002929688 796.6723022460938 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 621.2593702038757, 423.17144266968035)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, SREBP1c</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Changes/Inhibition, Cellular </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of ER stress</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">acid beta-oxidation </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (hepatocyte) </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, PXR/SXR</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hepatotoxicity</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">receptor driven direct and </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">indirect gene expression </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">changes </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">benzoquinone imine and </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">acylglucuronide metabolites </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 694.0261103536163, 364.7458332634487)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, PPAR&#x03b1;</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 929.7237960440582, 16.881629911946717)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Injury, Mitochondria</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 606.4113454138558, 109.48591430892891)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Mitochondrial fatty </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 612.7153622336431, 112.02756424946215)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">acid beta-oxidation </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 467.70917679050245, 257.3337745854965)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Liver fibrosis</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 362.1385285797755, 532.0541629114599)">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 359.3239497865675, 534.5958128519932)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hepatopathy, including a </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 358.3095286798488, 537.1374627925263)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">constellation of observable </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 369.3754076889784, 539.6791127330596)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">effects </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1057.4948787063508, 62.75897549814694)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase in inflammation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 3280.7978515625 -1306.107177734375 L 3330.7978515625 -1306.107177734375 L 3330.7978515625 -1256.107177734375 L 3280.7978515625 -1256.107177734375 L 3280.7978515625 -1306.107177734375 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1188.2840374069851, 40.565315403683016)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Glutathione homeostasis</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1848.19189453125 -1365.9755859375 L 1898.19189453125 -1365.9755859375 L 1898.19189453125 -1315.9755859375 L 1848.19189453125 -1315.9755859375 L 1848.19189453125 -1365.9755859375 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 923.355855946439, 29.672104762122885)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Disturbance, Lysosomal function</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, CD36</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 182.1321329757574, 530.3617063973843)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, steatosis</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 889.5217403055863, 422.28902157691397)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Release, Cytokine</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 588.3469356927508, 70.65612120919401)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, 3-hydroxyacyl-CoA </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">dehydrogenase type-2 activity </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 3016.627197265625 -1332.0438232421875 L 3066.627197265625 -1332.0438232421875 L 3066.627197265625 -1282.0438232421875 L 3016.627197265625 -1282.0438232421875 L 3016.627197265625 -1332.0438232421875 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1139.256393658422, 35.84607613656438)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Perturbation of cholesterol</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 931.2773671320451, 40.61588986637348)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Damage, Lipid bilayer</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Formation, Liver fibrosis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of specific nuclear </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">change </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PPAR-gamma </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">activation </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">3-hydroxy-3-methylglutaryl-CoA </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">reductase gene </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Phospholipase A</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Tumorigenesis, Hepatocellular </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">carcinoma </text>
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  <path d="M 1344.6761474609375 705.2138061523438 L 1394.6761474609375 705.2138061523438 L 1394.6761474609375 755.2138061523438 L 1344.6761474609375 755.2138061523438 L 1344.6761474609375 705.2138061523438 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Production, Reactive oxygen </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">species </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 581.8450132488143, 10.860048255783328)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PPAR-beta activation</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Glutathione synthesis</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -1994.1385498046875 1385.7833251953125 L -1944.1385498046875 1385.7833251953125 L -1944.1385498046875 1435.7833251953125 L -1994.1385498046875 1435.7833251953125 L -1994.1385498046875 1385.7833251953125 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 224.64015766064392, 527.820056456851)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Insufficient repair or </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mis-repair of pro-mutagenic </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">DNA adducts </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -117.07145690917969 113.85791778564453 L -67.07145690917969 113.85791778564453 L -67.07145690917969 163.85791015625 L -117.07145690917969 163.85791015625 L -117.07145690917969 113.85791778564453 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Steatohepatisis</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 864.5902848687359, 399.9010818051758)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Bile accumulation, Pathological </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">condition </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -163.8118896484375 -1467.799560546875 L -113.81189727783203 -1467.799560546875 L -113.81189727783203 -1417.799560546875 L -163.8118896484375 -1417.799560546875 L -163.8118896484375 -1467.799560546875 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 562.0193997827429, 9.874146081912487)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PPAR-alpha </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 569.384214291637, 12.415796022445749)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">activation </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 3282.78515625 -1170.799072265625 L 3332.78515625 -1170.799072265625 L 3332.78515625 -1120.799072265625 L 3282.78515625 -1120.799072265625 L 3282.78515625 -1170.799072265625 z"/>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1184.1407073375394, 63.91414775553294)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Down Regulation, GSS and GSTs </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Clonal Expansion/Cell </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Proliferation, to form Altered </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hepatic Foci (AHF) </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 727.6227570142955, 393.8665955540089)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, hepatocellular </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">adenomas and carcinomas </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Inflammation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, HSD17B10 </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">expression </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, Unsaturated </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">fatty acid </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Induced Mutations in </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, extracellular matrix </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decrease, Acyl-CoA </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, Acetyl-CoA </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">carboxylase-1 (ACC-1) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased reactive oxygen </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">species (in the mitochondria) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Nuclear factor kappa </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Glucocorticoid </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decrease in mitochondrial </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Tissue resident cells </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(Kuppfer cells) </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Liver Steatosis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, FAS</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Binding of inhibitor, </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">NADH-ubiquinone </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">oxidoreductase (complex I) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Necrotic Tissue</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 325.09043581980353, 281.2550095723062)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Cell injury/death</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Oncotic Necrosis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">androstane receptor, NR1l3 </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, NADH-ubiquinone </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">oxidoreductase  (complex I) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">activated receptor promoter </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial Complex V </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, IKK complex</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Mitochondrial dysfunction 1</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, cytosolic fatty acid</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, ChREBP</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial Complex IV </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Alkylation, Protein</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Endocytotic lysosomal uptake</text>
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  <path d="M -158.5929412841797 -196.25009155273438 L -98.59294891357422 -196.25009155273438 L -98.59294891357422 -136.25009155273438 L -158.5929412841797 -136.25009155273438 L -158.5929412841797 -196.25009155273438 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Reactive oxygen </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">species </text>
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  <path d="M 451.1681823730469 -377.94146728515625 L 511.1681823730469 -377.94146728515625 L 511.1681823730469 -317.94146728515625 L 451.1681823730469 -317.94146728515625 L 451.1681823730469 -377.94146728515625 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, LXR</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Mitochondrial complex </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">III antagonism </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Tissue resident cell activation</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased Pro-inflammatory </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mediators </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Regenerative cell </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proliferation (hepatocytes) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Proliferation, Cell proliferation in </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">the absence of cytotoxicity </text>
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  <path d="M 1227.541748046875 991.5259399414062 L 1277.541748046875 991.5259399414062 L 1277.541748046875 1041.52587890625 L 1227.541748046875 1041.52587890625 L 1227.541748046875 991.5259399414062 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Oxidative metabolism</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, PARP1</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Leukocyte recruitment/activation</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cytotoxicity </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, LDL uptake</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, fatty acid beta </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">oxidation </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Androgen receptor</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Damaging, Mitochondria</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hyperplasia, Hyperplasia</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Induction of pyruvate </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">dehydrogenase (PDH) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 583.2690386391105, 194.68297783211057)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, LDLR (low </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 581.5083277008595, 197.22462777264383)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">density lipoprotein receptor) </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 150.68396811713305, 570.6484527051311)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, HSD17B4 activity</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 720.3187340312616, 425.5806150596132)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Preneoplastic foci </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(hepatocytes) </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 404.63065018372805, 599.0550422801231)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Promotion, Hepatocelluar </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 412.84730122889994, 601.5966922206563)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">carcinoma </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Clonal Expansion of </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 733.3430352564811, 413.4644441676362)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Altered Hepatic Foci </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 832.1488882039666, 509.62479961187034)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Pyruvate </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 827.0234762538352, 512.1664495524036)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">dehydrogenase kinase (PDK) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">enzyme </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Suppression, VLDL secretion</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, PPARalpha</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 703.1757125322313, 404.0392478155196)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, cell proliferation </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(hepatocytes) </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Liver Cancer</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 699.916002949924, 380.5548172666011)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Phenotypic enzyme </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 711.9472611625572, 383.0964672071343)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">activity </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Peptide Oxidation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PCK1 expression </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(control point for </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">glycolysis/gluconeogenesis </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">pathway) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activated, LXR</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Ketogenesis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Formation, Hepatocellular and </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Bile duct tumors </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Induction, persistent </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proliferation/sustained </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proliferation </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">systemic inflammation leading </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 579.5448254110371, 123.27758361122027)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">to hepatic steatosis </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 617.4353788860029, 180.536426614469)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, AhR</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 159.80927145420947, 643.9429097203431)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, SHP activity</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 653.132009615191, 92.59542085274397)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Down Regulation, HMGCS2</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 842.554123024135, 436.2279609603951)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Cholestasis, Pathology</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 313.51772384443177, 552.7373190602981)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hepatocytotoxicity</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 607.7253860625923, 143.3162429731068)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, AKT2</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 670.3635863986952, 301.0855004366721)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, LXR alpha</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 172.61804817406366, 665.1004929763697)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, FXR activity</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 633.4174366076006, 92.75657281324051)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Down Regulation, CPT1A</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 1077.1893340944498, 76.28574522675466)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Immune mediated hepatitis</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 302.1142375305613, 537.2774587689594)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Oxidative Stress </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 644.5755079535822, 178.37288574974207)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, SREBF1</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 592.160407322485, 226.9253139003723)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, DHB4/HSD17B4</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 189.31770465904242, 682.6517194655435)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">NFE2/Nrf2 repression</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 664.9728972877629, 110.310608994786)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, FoxA2</text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 600.3952887456564, 272.9101718654276)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 352.3585780255983, 330.3413000963769)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, proinflammatory </text>
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 354.99458032340385, 332.8829500369102)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mediators (TNFalpha) </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.18195256844980773, 0, 0, 0.18195256844980773, 321.9853814784771, 530.3617063973843)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of Cyp2E1</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">IFN&#x03b3; signaling</text>
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