The Escape (ESC) symbol makes the subsequent character treated as a content character.
Example: USV with a unit that contains an Escape + End of Transmission, which is treated as content.
a␛␄b␟
In the rare case that you need a separator then content that starts with a carriage return or newline:
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You escape the carriage return or newline.
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This is because separators may be optionally be followed by any number of carriage returns and/or newlines, which is to help with visual display.