diff --git a/packages/main/src/ListItem.ts b/packages/main/src/ListItem.ts
index 8abc673e4c8..71648982c85 100644
--- a/packages/main/src/ListItem.ts
+++ b/packages/main/src/ListItem.ts
@@ -254,6 +254,10 @@ abstract class ListItem extends ListItemBase {
 	}
 
 	async _onkeydown(e: KeyboardEvent) {
+		if ((isSpace(e) || isEnter(e)) && this._isTargetSelfFocusDomRef(e)) {
+			return;
+		}
+
 		super._onkeydown(e);
 
 		const itemActive = this.type === ListItemType.Active,
@@ -328,6 +332,13 @@ abstract class ListItem extends ListItemBase {
 		}
 	}
 
+	_isTargetSelfFocusDomRef(e: KeyboardEvent): boolean {
+		const target = e.target as HTMLElement,
+			focusDomRef = this.getFocusDomRef();
+
+		return target !== focusDomRef;
+	}
+
 	/**
 	 * Called when selection components in Single (ui5-radio-button)
 	 * and Multi (ui5-checkbox) selection modes are used.