diff --git a/cmake/defaults/Options.cmake b/cmake/defaults/Options.cmake
index 74cee361fd..e2b7315417 100644
--- a/cmake/defaults/Options.cmake
+++ b/cmake/defaults/Options.cmake
@@ -240,3 +240,12 @@ if (${PXR_BUILD_PYTHON_DOCUMENTATION})
         set(PXR_BUILD_PYTHON_DOCUMENTATION "OFF" CACHE BOOL "" FORCE)
     endif()
 endif()
+
+set(PXR_IMAGING_HIO_STB_PRECEDENCE "30" CACHE STRING "Hio plugin precedence for Hio_StbImage.")
+set(PXR_IMAGING_HIO_STB_FORMATS "bmp;jpg;jpeg;png;tga;hdr" CACHE STRING "Image file formats handled by Hio_StbImage Hio plugin.")
+
+set(PXR_IMAGING_HIO_OPENEXR_PRECEDENCE "30" CACHE STRING "Hio plugin precedence for Hio_OpenEXRImage.")
+set(PXR_IMAGING_HIO_OPENEXR_FORMATS "exr" CACHE STRING "Image file formats handled by Hio_OpenEXRImage Hio plugin.")
+
+set(PXR_IMAGING_HIO_OIIO_PRECEDENCE "10" CACHE STRING "Hio plugin precedence for HioOIIO_Image.")
+set(PXR_IMAGING_HIO_OIIO_FORMATS "tif;tiff;zfile;tx" CACHE STRING "Image file formats handled by HioOIIO_Image Hio plugin.")
diff --git a/pxr/imaging/hio/CMakeLists.txt b/pxr/imaging/hio/CMakeLists.txt
index 75e1e62989..d79edd6210 100644
--- a/pxr/imaging/hio/CMakeLists.txt
+++ b/pxr/imaging/hio/CMakeLists.txt
@@ -1,6 +1,43 @@
 set(PXR_PREFIX pxr/imaging)
 set(PXR_PACKAGE hio)
 
+set (optionalCppFiles)
+set (optionalPrivateHeaders)
+if (PXR_IMAGING_HIO_STB_FORMATS)
+    list(APPEND optionalCppFiles
+        stbImage.cpp
+    )
+    list(APPEND optionalPrivateHeaders
+        stb/stb_image.h
+        stb/stb_image_resize2.h
+        stb/stb_image_write.h
+    )
+endif()
+if (PXR_IMAGING_HIO_OPENEXR_FORMATS)
+    list(APPEND optionalCppFiles
+        OpenEXRImage.cpp
+        OpenEXR/openexr-c.c
+    )
+    list(APPEND optionalPrivateHeaders
+        OpenEXR/openexr-c.h
+    )
+endif()
+
+set(JSON_HIO_STB_FORMATS ${PXR_IMAGING_HIO_STB_FORMATS})
+list(TRANSFORM JSON_HIO_STB_FORMATS REPLACE "[a-zA-Z0-9]+" "\"\\0\"")
+list(JOIN JSON_HIO_STB_FORMATS ", " JSON_HIO_STB_FORMATS)
+
+set(JSON_HIO_OPENEXR_FORMATS ${PXR_IMAGING_HIO_OPENEXR_FORMATS})
+list(TRANSFORM JSON_HIO_OPENEXR_FORMATS REPLACE "[a-zA-Z0-9]+" "\"\\0\"")
+list(JOIN JSON_HIO_OPENEXR_FORMATS ", " JSON_HIO_OPENEXR_FORMATS)
+
+file(READ "${CMAKE_CURRENT_LIST_DIR}/plugInfo.json.in" content)
+string(REPLACE "<JSON_HIO_OPENEXR_FORMATS>" "${JSON_HIO_OPENEXR_FORMATS}" content "${content}")
+string(REPLACE "<PXR_IMAGING_HIO_OPENEXR_PRECEDENCE>" "${PXR_IMAGING_HIO_OPENEXR_PRECEDENCE}" content "${content}")
+string(REPLACE "<JSON_HIO_STB_FORMATS>" "${JSON_HIO_STB_FORMATS}" content "${content}")
+string(REPLACE "<PXR_IMAGING_HIO_STB_PRECEDENCE>" "${PXR_IMAGING_HIO_STB_PRECEDENCE}" content "${content}")
+file(WRITE "${CMAKE_CURRENT_LIST_DIR}/plugInfo.json" "${content}")
+
 pxr_library(hio
     LIBRARIES
         arch
@@ -29,16 +66,11 @@ pxr_library(hio
         api.h
 
     PRIVATE_HEADERS
-        OpenEXR/openexr-c.h
         rankedTypeMap.h
-        stb/stb_image.h
-        stb/stb_image_resize2.h
-        stb/stb_image_write.h
+        ${optionalPrivateHeaders}
 
     CPPFILES
-        OpenEXRImage.cpp
-        OpenEXR/openexr-c.c
-        stbImage.cpp
+        ${optionalCppFiles}
 
     RESOURCE_FILES
         plugInfo.json
diff --git a/pxr/imaging/hio/plugInfo.json b/pxr/imaging/hio/plugInfo.json.in
similarity index 64%
rename from pxr/imaging/hio/plugInfo.json
rename to pxr/imaging/hio/plugInfo.json.in
index 70e5fb8d9c..17dfbb6cce 100644
--- a/pxr/imaging/hio/plugInfo.json
+++ b/pxr/imaging/hio/plugInfo.json.in
@@ -5,13 +5,12 @@
                 "Types": {
                    "Hio_OpenEXRImage" : {
                         "bases": ["HioImage"],
-                        "imageTypes": ["exr"],
-                        "precedence": 30
+                        "imageTypes": [<JSON_HIO_OPENEXR_FORMATS>],
+                        "precedence": <PXR_IMAGING_HIO_OPENEXR_PRECEDENCE>
                     },
                     "Hio_StbImage" : {
-                        "bases": ["HioImage"],
-                        "imageTypes": ["bmp", "jpg", "jpeg", "png", "tga", "hdr"],
-                        "precedence": 30
+                        "imageTypes": [<JSON_HIO_STB_FORMATS>],
+                        "precedence": <PXR_IMAGING_HIO_STB_PRECEDENCE>
                     }
                 }
             },
diff --git a/pxr/imaging/plugin/hioOiio/CMakeLists.txt b/pxr/imaging/plugin/hioOiio/CMakeLists.txt
index 0a055b711d..9842db59cb 100644
--- a/pxr/imaging/plugin/hioOiio/CMakeLists.txt
+++ b/pxr/imaging/plugin/hioOiio/CMakeLists.txt
@@ -7,6 +7,12 @@ if (NOT ${PXR_BUILD_GPU_SUPPORT})
     return()
 endif()
 
+if (NOT PXR_IMAGING_HIO_OIIO_FORMATS)
+    message(STATUS
+            "Skipping ${PXR_PACKAGE} because PXR_IMAGING_HIO_OIIO_FORMATS is empty")
+    return()
+endif()
+
 # Use the import targets set by Imath's package config
 if (Imath_FOUND)
     set(__OIIO_IMATH_LIBS "Imath::Imath")
@@ -15,6 +21,15 @@ else()
     set(__OIIO_IMATH_LIBS ${OPENEXR_LIBRARIES})
 endif()
 
+set(JSON_HIO_OIIO_FORMATS ${PXR_IMAGING_HIO_OIIO_FORMATS})
+list(TRANSFORM JSON_HIO_OIIO_FORMATS REPLACE "[a-zA-Z0-9]+" "\"\\0\"")
+list(JOIN JSON_HIO_OIIO_FORMATS ", " JSON_HIO_OIIO_FORMATS)
+
+file(READ "${CMAKE_CURRENT_LIST_DIR}/plugInfo.json.in" content)
+string(REPLACE "<JSON_HIO_OIIO_FORMATS>" "${JSON_HIO_OIIO_FORMATS}" content "${content}")
+string(REPLACE "<PXR_IMAGING_HIO_OIIO_PRECEDENCE>" "${PXR_IMAGING_HIO_OIIO_PRECEDENCE}" content "${content}")
+file(WRITE "${CMAKE_CURRENT_LIST_DIR}/plugInfo.json" "${content}")
+
 pxr_plugin(hioOiio
     LIBRARIES
         ar
diff --git a/pxr/imaging/plugin/hioOiio/plugInfo.json b/pxr/imaging/plugin/hioOiio/plugInfo.json.in
similarity index 75%
rename from pxr/imaging/plugin/hioOiio/plugInfo.json
rename to pxr/imaging/plugin/hioOiio/plugInfo.json.in
index 6a89df32d5..34e214b551 100644
--- a/pxr/imaging/plugin/hioOiio/plugInfo.json
+++ b/pxr/imaging/plugin/hioOiio/plugInfo.json.in
@@ -5,8 +5,8 @@
         "Types": {
           "HioOIIO_Image" : {
             "bases": ["HioImage"],
-            "imageTypes": ["tif", "tiff", "zfile", "tx"],
-            "precedence": 10
+            "imageTypes": [<JSON_HIO_OIIO_FORMATS>],
+            "precedence": <PXR_IMAGING_HIO_OIIO_PRECEDENCE>
           }
         }
       },