diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 197117ef2..b4205b21f 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -18,7 +18,7 @@ jobs:
     strategy:
       matrix:
         os: [ubuntu-22.04]
-        backend: [mkl, dnnl]
+        backend: [mkl, dnnl, asan]
 
     steps:
       - uses: actions/checkout@v4
@@ -50,6 +50,15 @@ jobs:
           sudo apt-get install -y intel-oneapi-dnnl-devel=$DNNL_VERSION intel-oneapi-dnnl=$DNNL_VERSION
           cmake -DCMAKE_INSTALL_PREFIX=$PWD/install -DBUILD_TESTS=ON -DWITH_MKL=OFF -DOPENMP_RUNTIME=COMP -DWITH_DNNL=ON .
 
+      - name: Configure with ASAN
+        if: startsWith(matrix.os, 'ubuntu') && matrix.backend == 'asan'
+        env:
+          DNNL_VERSION: 2023.0.0-25399
+        run: |
+          sudo apt-get install -y llvm libomp-dev intel-oneapi-dnnl-devel=$DNNL_VERSION intel-oneapi-dnnl=$DNNL_VERSION
+          cmake -DCMAKE_INSTALL_PREFIX=$PWD/install -DBUILD_TESTS=ON -DWITH_MKL=OFF -DOPENMP_RUNTIME=COMP -DWITH_DNNL=ON \
+            -DGOOGLE_ADDRESS_SANITIZER=ON -DCMAKE_BUILD_TYPE=Debug -DCMAKE_C_COMPILER=/usr/bin/clang -DCMAKE_CXX_COMPILER=/usr/bin/clang++ .
+
       - name: Build
         run: |
           make install
@@ -71,7 +80,10 @@ jobs:
         if: matrix.backend == 'dnnl'
         run: |
           tests/ctranslate2_test tests/data
-
+      - name: Test ASAN
+        if: matrix.backend == 'asan'
+        run: |
+          ASAN_OPTIONS=detect_leaks=1:print_stats=1  tests/ctranslate2_test tests/data
 
   build-and-test-cpp-aarch64:
     runs-on: ubuntu-22.04
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 62b99d136..c7a95cd0f 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -22,6 +22,8 @@ option(BUILD_TESTS "Compile the tests" OFF)
 option(BUILD_SHARED_LIBS "Build shared libraries" ON)
 option(WITH_TENSOR_PARALLEL "Compile with NCCL and MPI backend" OFF)
 option(WITH_FLASH_ATTN "Compile with Flash Attention 2" OFF)
+option(GOOGLE_ADDRESS_SANITIZER "ASAN" OFF)
+
 
 if(ENABLE_PROFILING)
   message(STATUS "Enable profiling support")
@@ -444,6 +446,16 @@ if (WITH_RUY)
   list(APPEND LIBRARIES ruy)
 endif()
 
+IF (GOOGLE_ADDRESS_SANITIZER AND (CMAKE_BUILD_TYPE STREQUAL "Debug" OR CMAKE_BUILD_TYPE STREQUAL "DEBUG"))
+  MESSAGE (STATUS "GOOGLE_ADDRESS_SANITIZER: ENABLED")
+  set(ASAN_FLAGS " -fsanitize=address -fno-omit-frame-pointer -fno-optimize-sibling-calls -fno-common")
+  string(APPEND CMAKE_C_FLAGS ${ASAN_FLAGS})
+  string(APPEND CMAKE_CXX_FLAGS ${ASAN_FLAGS})
+  add_link_options(-fsanitize=address)
+ELSEIF (GOOGLE_ADDRESS_SANITIZER)
+  MESSAGE(FATAL_ERROR "SANITIZER requires Debug build type")
+ENDIF ()
+
 if (WITH_CUDA)
   find_package(CUDA 11.0 REQUIRED)
   list(APPEND CMAKE_MODULE_PATH ${PROJECT_SOURCE_DIR}/cmake)