Skip to content

Blinded estimation of the treatment effect under stratified design #606

@LittleBeannie

Description

@LittleBeannie

Unstratified design

Assume there are $M$ pieces of HRs. For a certain analysis $k$, the blinded estimation of the treatment effect is
$\sum_m^M HR_m \times \frac{\text{events for the m-th interval at analysis k} }{ \text{events at analysis k} }$

Stratified design

There are $S$ strata. For stratum $s$, its HR is piecewise, i.e., $HR_{s,1}, HR_{s,2}, ... HR_{s,M}$.The blinded estimation of the treatment effect is
$\sum_s^S \sum_m^M HR_{s,m} \times \frac{\text{events for the m-th interval at analysis k and stratum s} }{ \text{events across strata at analysis k} }$

We will update gs_update_ahr to enable the blinded estimation of treatment effect under a stratified design.

Metadata

Metadata

Assignees

No one assigned

    Labels

    No labels
    No labels

    Type

    No type

    Projects

    No projects

    Milestone

    No milestone

    Relationships

    None yet

    Development

    No branches or pull requests

    Issue actions