diff --git a/assets/js/autocomplete.js b/assets/js/autocomplete.js
index 7f152cc614..f8765f9d2f 100644
--- a/assets/js/autocomplete.js
+++ b/assets/js/autocomplete.js
@@ -110,7 +110,13 @@ export default class Autocomplete {
             labelField: 'entityAsString',
             searchField: ['entityAsString'],
             firstUrl: (query) => {
-                return `${autocompleteEndpointUrl}&query=${encodeURIComponent(query)}`;
+                const url = new URL(autocompleteEndpointUrl);
+                url.searchParams.append(`query`, query);
+                this.#resolveAutocompleteDependencyFields(element).forEach((dependency) => {
+                    url.searchParams.append(`autocompleteDependsOn[${dependency.path}]`, dependency.element.value);
+                });
+
+                return url.toString();
             },
             // VERY IMPORTANT: use 'function (query, callback) { ... }' instead of the
             // '(query, callback) => { ... }' syntax because, otherwise,
@@ -145,7 +151,11 @@ export default class Autocomplete {
             },
         });
 
-        return this.#initializeTomSelect(element, config);
+        const tomSelect = this.#initializeTomSelect(element, config);
+
+        this.#bindAutocompleteDependencyFieldListeners(tomSelect);
+
+        return tomSelect;
     }
 
     #initializeTomSelect(element, config) {
@@ -258,4 +268,41 @@ export default class Autocomplete {
 
         return { options, optgroups };
     }
+
+    #bindAutocompleteDependencyFieldListeners(tomSelect) {
+        this.#resolveAutocompleteDependencyFields(tomSelect.input).forEach((dependency) => {
+            dependency.element.addEventListener('change', () => {
+                tomSelect.clear();
+                tomSelect.clearOptions();
+                tomSelect.clearOptionGroups();
+                tomSelect.clearPagination();
+                tomSelect.wrapper.classList.remove('preloaded');
+            });
+        });
+    }
+
+    #resolveAutocompleteDependencyFields(element) {
+        const dependsOn = JSON.parse(element.getAttribute('data-ea-autocomplete-depends-on') || '[]');
+        const form = element.closest('form');
+
+        if (null === form) {
+            return [];
+        }
+
+        return dependsOn.map((field) => {
+            const fieldId = `${form.name}_${field.replaceAll('.', '_')}`;
+            const fieldElement = document.getElementById(fieldId) ?? document.getElementById(`${fieldId}_autocomplete`);
+
+            if (null === fieldElement) {
+                console.error(`No field found for autocomplete dependency "${field}".`);
+                return null;
+            }
+
+            return {
+                path: field,
+                element: fieldElement,
+            };
+        })
+        .filter((dependencyField) => null !== dependencyField);
+    }
 }
diff --git a/src/Controller/AbstractCrudController.php b/src/Controller/AbstractCrudController.php
index cc73525fd2..a489914be9 100644
--- a/src/Controller/AbstractCrudController.php
+++ b/src/Controller/AbstractCrudController.php
@@ -561,7 +561,8 @@ public function autocomplete(AdminContext $context): JsonResponse
         $queryBuilderCallable = $field?->getCustomOption(AssociationField::OPTION_QUERY_BUILDER_CALLABLE);
 
         if (null !== $queryBuilderCallable) {
-            $queryBuilder = $queryBuilderCallable($queryBuilder) ?? $queryBuilder;
+            $autocompleteDependsOn = $context->getRequest()->query->all('autocompleteDependsOn');
+            $queryBuilder = $queryBuilderCallable($queryBuilder, $autocompleteDependsOn) ?? $queryBuilder;
         }
 
         $callback = $field?->getCustomOption(AssociationField::OPTION_AUTOCOMPLETE_CALLBACK)
diff --git a/src/Field/AssociationField.php b/src/Field/AssociationField.php
index a70b9ebd84..32bdae5bca 100644
--- a/src/Field/AssociationField.php
+++ b/src/Field/AssociationField.php
@@ -16,6 +16,7 @@ final class AssociationField implements FieldInterface
     public const OPTION_AUTOCOMPLETE = 'autocomplete';
     public const OPTION_AUTOCOMPLETE_CALLBACK = 'autocompleteCallback';
     public const OPTION_AUTOCOMPLETE_TEMPLATE = 'autocompleteTemplate';
+    public const OPTION_AUTOCOMPLETE_DEPENDS_ON = 'autocompleteDependsOn';
     public const OPTION_EMBEDDED_CRUD_FORM_CONTROLLER = 'crudControllerFqcn';
     public const OPTION_WIDGET = 'widget';
     public const OPTION_QUERY_BUILDER_CALLABLE = 'queryBuilderCallable';
@@ -52,6 +53,7 @@ public static function new(string $propertyName, TranslatableInterface|string|bo
             ->setCustomOption(self::OPTION_AUTOCOMPLETE, false)
             ->setCustomOption(self::OPTION_AUTOCOMPLETE_CALLBACK, null)
             ->setCustomOption(self::OPTION_AUTOCOMPLETE_TEMPLATE, null)
+            ->setCustomOption(self::OPTION_AUTOCOMPLETE_DEPENDS_ON, null)
             ->setCustomOption(self::OPTION_EMBEDDED_CRUD_FORM_CONTROLLER, null)
             ->setCustomOption(self::OPTION_WIDGET, self::WIDGET_AUTOCOMPLETE)
             ->setCustomOption(self::OPTION_QUERY_BUILDER_CALLABLE, null)
@@ -64,7 +66,10 @@ public static function new(string $propertyName, TranslatableInterface|string|bo
             ->setCustomOption(self::OPTION_PREFERRED_CHOICES, null);
     }
 
-    public function autocomplete(bool $enable = true, ?callable $callback = null, ?string $template = null, bool $renderAsHtml = false): self
+    /**
+     * @param list<string>|string|null $dependsOn
+     */
+    public function autocomplete(bool $enable = true, ?callable $callback = null, ?string $template = null, bool $renderAsHtml = false, array|string|null $dependsOn = null): self
     {
         if (!$enable) {
             return $this;
@@ -83,6 +88,10 @@ public function autocomplete(bool $enable = true, ?callable $callback = null, ?s
         // the renderAsHtml parameter controls the same option as renderAsHtml() method
         $this->setCustomOption(self::OPTION_ESCAPE_HTML_CONTENTS, !$renderAsHtml);
 
+        if (null !== $dependsOn) {
+            $this->setCustomOption(self::OPTION_AUTOCOMPLETE_DEPENDS_ON, \is_string($dependsOn) ? [$dependsOn] : $dependsOn);
+        }
+
         return $this;
     }
 
diff --git a/src/Field/Configurator/AssociationConfigurator.php b/src/Field/Configurator/AssociationConfigurator.php
index c30b90b339..46fdde35a4 100644
--- a/src/Field/Configurator/AssociationConfigurator.php
+++ b/src/Field/Configurator/AssociationConfigurator.php
@@ -203,6 +203,11 @@ public function configure(FieldDto $field, EntityDto $entityDto, AdminContext $c
             } elseif (null !== $autocompleteTemplate) {
                 $field->setFormTypeOption('autocomplete_template', $autocompleteTemplate);
             }
+
+            $autocompleteDependsOn = $field->getCustomOption(AssociationField::OPTION_AUTOCOMPLETE_DEPENDS_ON);
+            if (null !== $autocompleteDependsOn) {
+                $field->setFormTypeOption('attr.data-ea-autocomplete-depends-on', json_encode($autocompleteDependsOn));
+            }
         } else {
             $field->setFormTypeOptionIfNotSet('query_builder', static function (EntityRepository $repository) use ($field) {
                 // TODO: should this use `createIndexQueryBuilder` instead, so we get the default ordering etc.?