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iss-ah-predictor

Blum et al. [1] developed a set of algorithms for the prediction of adult height (AH) in patients with idiopathic short stature (ISS), based on a German-Dutch cohort. The iss-ah-predictor is a convenient Perl implementation of these algorithms.

Depending of the amount of available patient properties, a specific set of parameters is used to calculate AH. The following properties are used in the algorithms:

property unit LOINC code hash key for perl functions
chronological age years 30525-0 age
body height at baseline cm 3137-7 body_height
Tanner target height [2] cm target_height
mother height cm 83846-6 mother_height
father height cm 83845-8 father_height
bone age years 85151-9 bone_age
birth weight kg 8339-4 birth_weight
sex male, female 46098-0 sex

Installation

cpan Iss::Ah::Predictor

After installing, you can find documentation for this module with the perldoc command.

perldoc Iss::Ah::Predictor

You can also look for information at:

Search CPAN
    http://search.cpan.org/dist/iss-ah-predictor/

Build from Source

perl Makefile.PL
make
make test
make install

Usage

Just call ISS::AH::Predictor::predict(...) and provide property values from the table above. The function will pick an appropriate parameter set and will calculate the adult height.

my $prediction = ISS::AH::Predictor::predict(
  age           => 12,
  body_height   => 130,
  father_height => 180,
  bone_age      => 12,     # will be converted with property age to bone_age_per_age
  sex           => 'male', # 'male' or 'female'
); # => adult height prediction: 164.6488 cm

You can also provide custom module parameters via hash key "models":

my $prediction = ISS::AH::Predictor::predict(
  age           => 12,
  body_height   => 130,
  father_height => 180,
  bone_age      => 12,
  sex           => 'male',
  models        => [
    [ 63.3339,  -2.9595, 0.7256, 0.3173, undef,  undef,  -13.0399, 1.2695, -6.2213 ], # parameters of model 1
    [ 62.1795,  -2.9892, 0.7328, 0.3442, undef,  undef,  -12.6821, undef,  -6.3021 ], # parameters of model 2
  ],
);

Models must be provided as follows:

Each model parameter set is enclosed in an arrayref. The index of the parameter in this arrayref determines for which property the parameter is used. The order is defined by the constant ISS::AH::Predictor::PARAMETER_NAMES:

use constant PARAMETER_NAMES => {
  0 => 'intercept',
  1 => 'age',
  2 => 'body_height',
  3 => 'target_height',
  4 => 'mother_height',
  5 => 'father_height',
  6 => 'bone_age_per_age',
  7 => 'birth_weight',
  8 => 'sex',
};

References

[1] Blum WF, Ranke MB, Keller E, Keller A, Barth S, de Bruin C, Wudy SA, Wit JM. A Novel Method for Adult Height Prediction in Children With Idiopathic Short Stature Derived From a German-Dutch Cohort. Journal of the Endocrine Society, Volume 6, Issue 7, July 2022, bvac074. https://doi.org/10.1210/jendso/bvac074

[2] Tanner JM, Goldstein H, Whitehouse RH. Standards for Children's Height at Ages 2-9 Years Allowing for Height of Parents. Archives of Disease in Childhood, 1970, 45:755-762. https://doi.org/10.1136/adc.45.244.755

License and Copyright

Copyright (C) 2017-2022 CrescNet, Leipzig University

This program is released under the following license: MIT