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We encountered a sample with multiple allele variants for a SNP ( REF/ALT --> G/T and G/A). Upon investigation of the BCF file we saw that it the reads were split almost 50-50 between A and T at that position. Currently, Genotype raises a valueError in such cases, which might happen again in the future.
Suggested solution
Pick one of the two or define it as a None call. In the latter case raising a flag with a statusDB entry (or similar) might be a good idea.
This can be closed when
A decision has been reached on how to proceed and the to be determined intended goals are reached.
Blocked by
None
The text was updated successfully, but these errors were encountered:
karlnyr
transferred this issue from Clinical-Genomics/genotype
Apr 3, 2024
Description
We encountered a sample with multiple allele variants for a SNP ( REF/ALT --> G/T and G/A). Upon investigation of the BCF file we saw that it the reads were split almost 50-50 between A and T at that position. Currently, Genotype raises a valueError in such cases, which might happen again in the future.
Suggested solution
Pick one of the two or define it as a None call. In the latter case raising a flag with a statusDB entry (or similar) might be a good idea.
This can be closed when
A decision has been reached on how to proceed and the to be determined intended goals are reached.
Blocked by
None
The text was updated successfully, but these errors were encountered: