diff --git a/.bumpversion.cfg b/.bumpversion.cfg
index 52137f77aa..d101e6cae2 100644
--- a/.bumpversion.cfg
+++ b/.bumpversion.cfg
@@ -1,5 +1,5 @@
 [bumpversion]
-current_version = 62.2.4
+current_version = 62.2.5
 commit = True
 tag = True
 tag_name = v{new_version}
diff --git a/cg/__init__.py b/cg/__init__.py
index a7779ad0db..7870f9e682 100644
--- a/cg/__init__.py
+++ b/cg/__init__.py
@@ -1,2 +1,2 @@
 __title__ = "cg"
-__version__ = "62.2.4"
+__version__ = "62.2.5"
diff --git a/cg/clients/freshdesk/freshdesk_client.py b/cg/clients/freshdesk/freshdesk_client.py
index 535ef06821..9a9650f9b1 100644
--- a/cg/clients/freshdesk/freshdesk_client.py
+++ b/cg/clients/freshdesk/freshdesk_client.py
@@ -1,19 +1,13 @@
-import logging
 from http import HTTPStatus
+from pathlib import Path
 
-from pydantic import ValidationError
-from requests import RequestException, Response, Session
+from requests import Session
 from requests.adapters import HTTPAdapter
 from urllib3 import Retry
 
 from cg.clients.freshdesk.constants import EndPoints
-from cg.clients.freshdesk.exceptions import (
-    FreshdeskAPIException,
-    FreshdeskModelException,
-)
-from cg.clients.freshdesk.models import TicketCreate, TicketResponse
-
-LOG = logging.getLogger(__name__)
+from cg.clients.freshdesk.models import ReplyCreate, TicketCreate, TicketResponse
+from cg.clients.freshdesk.utils import handle_client_errors, prepare_attachments
 
 
 class FreshdeskClient:
@@ -24,33 +18,23 @@ def __init__(self, base_url: str, api_key: str):
         self.api_key = api_key
         self.session = self._get_session()
 
-    def create_ticket(self, ticket: TicketCreate) -> TicketResponse:
-        """Create a ticket."""
-        LOG.debug(ticket.model_dump_json())
-        try:
-            response: Response = self.session.post(
-                url=self._url(EndPoints.TICKETS),
-                json=ticket.model_dump(exclude_none=True),
-            )
-            response.raise_for_status()
-            return TicketResponse.model_validate(response.json())
-        except RequestException as error:
-            LOG.error(f"Could not create ticket: {error}")
-            raise FreshdeskAPIException(error) from error
-        except ValidationError as error:
-            LOG.error(f"Response from Freshdesk does not fit model: {TicketResponse}.\n{error}")
-            raise FreshdeskModelException(error) from error
+    @handle_client_errors
+    def create_ticket(self, ticket: TicketCreate, attachments: list[Path] = None) -> TicketResponse:
+        """Create a ticket with multipart form data."""
+        multipart_data = ticket.to_multipart_data()
+        files = prepare_attachments(attachments) if attachments else None
 
-    def _url(self, endpoint: str) -> str:
-        """Get the full URL for the endpoint."""
-        return f"{self.base_url}{endpoint}"
+        response = self.session.post(
+            url=f"{self.base_url}{EndPoints.TICKETS}", data=multipart_data, files=files
+        )
+        response.raise_for_status()
+        return TicketResponse.model_validate(response.json())
 
+    @handle_client_errors
     def _get_session(self) -> Session:
-        """Configures and sets a session to be used for requests."""
         session = Session()
-        self._configure_retries(session)
         session.auth = (self.api_key, "X")
-        session.headers.update({"Content-Type": "application/json"})
+        self._configure_retries(session)
         return session
 
     @staticmethod
@@ -69,3 +53,14 @@ def _configure_retries(session: Session) -> None:
         )
         adapter = HTTPAdapter(max_retries=retry_strategy)
         session.mount("https://", adapter)
+
+    @handle_client_errors
+    def reply_to_ticket(self, reply: ReplyCreate, attachments: list[Path] = None) -> None:
+        """Send a reply to an existing ticket in Freshdesk."""
+        url = f"{self.base_url}{EndPoints.TICKETS}/{reply.ticket_number}/reply"
+
+        files = prepare_attachments(attachments) if attachments else None
+        multipart_data = reply.to_multipart_data()
+
+        response = self.session.post(url=url, data=multipart_data, files=files)
+        response.raise_for_status()
diff --git a/cg/clients/freshdesk/models.py b/cg/clients/freshdesk/models.py
index 7a0cae7f43..aa0be87ab4 100644
--- a/cg/clients/freshdesk/models.py
+++ b/cg/clients/freshdesk/models.py
@@ -1,6 +1,6 @@
-from datetime import datetime
+from typing import Tuple, Union
 
-from pydantic import BaseModel
+from pydantic import BaseModel, EmailStr, Field
 
 from cg.clients.freshdesk.constants import Priority, Source, Status
 
@@ -8,9 +8,10 @@
 class TicketCreate(BaseModel):
     """Freshdesk ticket."""
 
-    attachments: list[dict[str, str]] = []
-    email: str
+    attachments: list[str | bytes] = Field(default_factory=list)
+    email: EmailStr
     email_config_id: int | None = None
+    description: str
     name: str
     priority: int = Priority.LOW
     source: int = Source.EMAIL
@@ -18,19 +19,43 @@ class TicketCreate(BaseModel):
     subject: str
     tags: list[str] = []
     type: str | None = None
+    custom_fields: dict[str, str | int | float | None] = Field(default_factory=dict)
+
+    def to_multipart_data(self) -> list[Tuple[str, str | int | bytes]]:
+        """Custom converter to multipart form data."""
+        multipart_data = []
+
+        for field, value in self.model_dump(exclude_none=True).items():
+            if isinstance(value, list):
+                multipart_data.extend([(f"{field}[]", v) for v in value])
+            elif isinstance(value, dict):
+                multipart_data.extend([(f"{field}[{k}]", v) for k, v in value.items()])
+            else:
+                multipart_data.append((field, value))
+
+        return multipart_data
 
 
 class TicketResponse(BaseModel):
-    """Freshdesk ticket response."""
+    """Response from Freshdesk"""
 
-    attachments: list[dict[str, str]] = []
-    created_at: datetime | None = None
-    email: str
     id: int
-    name: str | None = None
-    priority: int
-    source: int
-    status: int
+    description: str
     subject: str
-    tags: list[str] = []
-    type: str | None = None
+    to_emails: list[str] | None = None
+    status: int
+    priority: int
+
+
+class ReplyCreate(BaseModel):
+    """Reply to a ticket."""
+
+    ticket_number: str
+    body: str
+
+    def to_multipart_data(self) -> list[Tuple[str, Union[str, int, bytes]]]:
+        """Custom converter to multipart form data."""
+        multipart_data = [
+            ("body", self.body),
+        ]
+        return multipart_data
diff --git a/cg/clients/freshdesk/utils.py b/cg/clients/freshdesk/utils.py
new file mode 100644
index 0000000000..2e78b23cf9
--- /dev/null
+++ b/cg/clients/freshdesk/utils.py
@@ -0,0 +1,86 @@
+import logging
+from functools import wraps
+from pathlib import Path
+from tempfile import TemporaryDirectory
+
+from pydantic import ValidationError
+from requests import ConnectionError, HTTPError
+from requests.exceptions import MissingSchema
+
+from cg.clients.freshdesk.exceptions import (
+    FreshdeskAPIException,
+    FreshdeskModelException,
+)
+from cg.constants.constants import FileFormat
+from cg.io.controller import WriteFile
+
+LOG = logging.getLogger(__name__)
+
+
+def extract_error_detail(error):
+    """Extract detailed error information from HTTPError."""
+    if error.response is not None:
+        try:
+            return error.response.json()
+        except ValueError:
+            return error.response.text
+    return None
+
+
+def log_and_raise(exception_class, message, error):
+    """Log the error and raise the appropriate exception."""
+    LOG.error(message)
+    raise exception_class(error) from error
+
+
+def handle_client_errors(func):
+    """Decorator to handle and log errors in Freshdesk client methods."""
+
+    @wraps(func)
+    def wrapper(*args, **kwargs):
+        try:
+            return func(*args, **kwargs)
+        except HTTPError as error:
+            error_detail = extract_error_detail(error)
+            log_and_raise(
+                FreshdeskAPIException,
+                f"Failed request to Freshdesk: {error} - Status code: "
+                f"{error.response.status_code if error.response else 'N/A'}, Details: {error_detail}",
+                error,
+            )
+        except (MissingSchema, ConnectionError) as error:
+            log_and_raise(FreshdeskAPIException, f"Request to Freshdesk failed: {error}", error)
+        except ValidationError as error:
+            log_and_raise(
+                FreshdeskModelException, f"Invalid response from Freshdesk: {error}", error
+            )
+        except ValueError as error:
+            log_and_raise(FreshdeskAPIException, f"Operation failed: {error}", error)
+        except Exception as error:
+            log_and_raise(
+                FreshdeskAPIException, f"Unexpected error in Freshdesk client: {error}", error
+            )
+
+    return wrapper
+
+
+def prepare_attachments(attachments: list[Path]) -> list[tuple[str, tuple[str, bytes]]]:
+    """Prepare the attachments for a request."""
+    return [
+        ("attachments[]", (attachment.name, open(attachment, "rb"))) for attachment in attachments
+    ]
+
+
+def create_temp_attachment_file(content: dict, file_name: Path) -> TemporaryDirectory:
+    """Create a file-based attachment."""
+    if content and file_name:
+        directory = TemporaryDirectory()
+        WriteFile.write_file_from_content(
+            content=content,
+            file_format=FileFormat.JSON,
+            file_path=Path(directory.name, "order.json"),
+        )
+        return directory
+    else:
+        LOG.error("Content or file path is None. Cannot create file attachment.")
+        raise ValueError("Both content and file path must be provided and cannot be None")
diff --git a/cg/meta/orders/api.py b/cg/meta/orders/api.py
index 0222d4f971..228a9570e0 100644
--- a/cg/meta/orders/api.py
+++ b/cg/meta/orders/api.py
@@ -10,7 +10,6 @@
 import logging
 
 from cg.apps.lims import LimsAPI
-from cg.apps.osticket import OsTicket
 from cg.meta.orders.ticket_handler import TicketHandler
 from cg.models.orders.order import OrderIn, OrderType
 from cg.services.orders.submitters.order_submitter_registry import (
@@ -28,13 +27,13 @@ def __init__(
         self,
         lims: LimsAPI,
         status: Store,
-        osticket: OsTicket,
+        ticket_handler: TicketHandler,
         submitter_registry: OrderSubmitterRegistry,
     ):
         super().__init__()
         self.lims = lims
         self.status = status
-        self.ticket_handler: TicketHandler = TicketHandler(osticket_api=osticket, status_db=status)
+        self.ticket_handler = ticket_handler
         self.submitter_registry = submitter_registry
 
     def submit(self, project: OrderType, order_in: OrderIn, user_name: str, user_mail: str) -> dict:
@@ -45,7 +44,7 @@ def submit(self, project: OrderType, order_in: OrderIn, user_name: str, user_mai
         submit_handler = self.submitter_registry.get_order_submitter(project)
         submit_handler.order_validation_service.validate_order(order_in)
         # detect manual ticket assignment
-        ticket_number: str | None = TicketHandler.parse_ticket_number(order_in.name)
+        ticket_number: str | None = self.ticket_handler.parse_ticket_number(order_in.name)
         if not ticket_number:
             ticket_number = self.ticket_handler.create_ticket(
                 order=order_in, user_name=user_name, user_mail=user_mail, project=project
@@ -54,7 +53,6 @@ def submit(self, project: OrderType, order_in: OrderIn, user_name: str, user_mai
             self.ticket_handler.connect_to_ticket(
                 order=order_in,
                 user_name=user_name,
-                user_mail=user_mail,
                 project=project,
                 ticket_number=ticket_number,
             )
diff --git a/cg/meta/orders/ticket_handler.py b/cg/meta/orders/ticket_handler.py
index ba6074068f..91d806fdfa 100644
--- a/cg/meta/orders/ticket_handler.py
+++ b/cg/meta/orders/ticket_handler.py
@@ -4,9 +4,8 @@
 from tempfile import TemporaryDirectory
 from typing import Any
 
-from sendmail_container import FormDataRequest
-
-from cg.apps.osticket import OsTicket
+from cg.clients.freshdesk.freshdesk_client import FreshdeskClient
+from cg.clients.freshdesk.models import ReplyCreate, TicketCreate, TicketResponse
 from cg.models.orders.order import OrderIn
 from cg.models.orders.samples import Of1508Sample
 from cg.store.models import Customer, Sample
@@ -20,15 +19,17 @@ class TicketHandler:
 
     NEW_LINE = "<br />"
 
-    def __init__(self, osticket_api: OsTicket, status_db: Store):
-        self.osticket: OsTicket = osticket_api
-        self.status_db: Store = status_db
+    def __init__(self, db: Store, client: FreshdeskClient, system_email_id: int, env: str):
+        self.client: FreshdeskClient = client
+        self.status_db: Store = db
+        self.system_email_id: int = system_email_id
+        self.env: str = env
 
     @staticmethod
     def parse_ticket_number(name: str) -> str | None:
         """Try to parse a ticket number from a string"""
         # detect manual ticket assignment
-        ticket_match = re.fullmatch(r"#([0-9]{6})", name)
+        ticket_match = re.fullmatch(r"#(\d{6,10})", name)
         if ticket_match:
             ticket_id = ticket_match.group(1)
             LOG.info(f"{ticket_id}: detected ticket in order name")
@@ -45,22 +46,36 @@ def create_ticket(
             order=order,
             project=project,
         )
-        attachment: dict = self.create_attachment(order=order)
-        ticket_nr: str | None = self.osticket.open_ticket(
-            name=user_name,
-            email=user_mail,
-            subject=order.name,
-            message=message,
-            attachment=attachment,
-        )
-        LOG.info(f"{ticket_nr}: opened new ticket")
 
-        return ticket_nr
+        with TemporaryDirectory() as temp_dir:
+            attachments: Path = self.create_attachment_file(order=order, temp_dir=temp_dir)
+
+            freshdesk_ticket = TicketCreate(
+                email=user_mail,
+                description=message,
+                email_config_id=self.system_email_id,
+                name=user_name,
+                subject=order.name,
+                type="Order",
+                tags=[order.samples[0].data_analysis],
+                custom_fields={
+                    "cf_environment": self.env,
+                },
+                attachments=[],
+            )
+            ticket_response: TicketResponse = self.client.create_ticket(
+                ticket=freshdesk_ticket, attachments=[attachments]
+            )
+            LOG.info(f"{ticket_response.id}: opened new ticket in Freshdesk")
 
-    def create_attachment(self, order: OrderIn):
-        return self.osticket.create_new_ticket_attachment(
-            content=self.replace_empty_string_with_none(obj=order.dict()), file_name="order.json"
-        )
+        return ticket_response.id
+
+    def create_attachment_file(self, order: OrderIn, temp_dir: str) -> Path:
+        """Create a single attachment file for the ticket"""
+        order_file_path = Path(temp_dir) / "order.json"
+        with order_file_path.open("w") as order_file:
+            order_file.write(order.json())
+        return order_file_path
 
     def create_xml_sample_list(self, order: OrderIn, user_name: str) -> str:
         message = ""
@@ -88,10 +103,7 @@ def create_xml_sample_list(self, order: OrderIn, user_name: str) -> str:
 
     @staticmethod
     def create_new_ticket_header(message: str, order: OrderIn, project: str) -> str:
-        return (
-            f"data:text/html;charset=utf-8, New order with {len(order.samples)} {project} samples:"
-            + message
-        )
+        return f"New order with {len(order.samples)} {project} samples:" + message
 
     @staticmethod
     def add_existing_ticket_header(message: str, order: OrderIn, project: str) -> str:
@@ -178,27 +190,25 @@ def replace_empty_string_with_none(cls, obj: Any) -> Any:
         return obj
 
     def connect_to_ticket(
-        self, order: OrderIn, user_name: str, user_mail: str, project: str, ticket_number: str
+        self, order: OrderIn, user_name: str, project: str, ticket_number: str
     ) -> None:
         """Appends a new order message to the ticket selected by the customer"""
         LOG.info(f"Connecting order to ticket {ticket_number}")
+
         message: str = self.add_existing_ticket_header(
             message=self.create_xml_sample_list(order=order, user_name=user_name),
             order=order,
             project=project,
         )
-        sender_prefix, email_server_alias = user_mail.split("@")
-        temp_dir: TemporaryDirectory = self.osticket.create_connecting_ticket_attachment(
-            content=self.replace_empty_string_with_none(obj=order.dict())
-        )
-        email_form = FormDataRequest(
-            sender_prefix=sender_prefix,
-            email_server_alias=email_server_alias,
-            request_uri=self.osticket.email_uri,
-            recipients=self.osticket.osticket_email,
-            mail_title=f"[#{ticket_number}]",
-            mail_body=message,
-            attachments=[Path(f"{temp_dir.name}/order.json")],
-        )
-        email_form.submit()
-        temp_dir.cleanup()
+
+        with TemporaryDirectory() as temp_dir:
+            attachments: Path = self.create_attachment_file(order=order, temp_dir=temp_dir)
+
+            reply = ReplyCreate(ticket_number=ticket_number, body=message)
+
+            self.client.reply_to_ticket(
+                reply=reply,
+                attachments=[attachments],
+            )
+
+            LOG.info(f"Connected order to ticket {ticket_number} in Freshdesk")
diff --git a/cg/server/app.py b/cg/server/app.py
index c9f3cd477c..4df92b1db4 100644
--- a/cg/server/app.py
+++ b/cg/server/app.py
@@ -66,8 +66,6 @@ def _configure_extensions(app: Flask):
     ext.db.init_app(app)
     ext.lims.init_app(app)
     ext.analysis_client.init_app(app)
-    if app.config["osticket_api_key"]:
-        ext.osticket.init_app(app)
     ext.admin.init_app(app, index_view=AdminIndexView(endpoint="admin"))
     app.json_provider_class = ext.CustomJSONEncoder
 
diff --git a/cg/server/app_config.py b/cg/server/app_config.py
index 34e8fe96ba..97f38b3235 100644
--- a/cg/server/app_config.py
+++ b/cg/server/app_config.py
@@ -2,25 +2,29 @@
 
 
 class AppConfig(BaseSettings):
+    """Default values are overridden by environment variable at run-time."""
+
     gunicorn_workers: int = 4
     gunicorn_threads: int = 4
-    gunicorn_bind: str
+    gunicorn_bind: str = "0.0.0.0:8000"
     gunicorn_timeout: int = 400
-    cg_sql_database_uri: str
+    cg_sql_database_uri: str = "sqlite:///"
     cg_secret_key: str = "thisIsNotASafeKey"
     invoice_max_price: int = 750_000
-    lims_host: str
-    lims_username: str
-    lims_password: str
-    osticket_api_key: str
-    osticket_domain: str
-    support_system_email: str
-    email_uri: str
-    google_oauth_client_id: str
-    google_oauth_client_secret: str
-    trailblazer_host: str
-    trailblazer_service_account: str
-    trailblazer_service_account_auth_file: str
+    lims_host: str = "lims_host"
+    lims_username: str = "username"
+    lims_password: str = "password"
+    support_system_email: str = "support@mail.com"
+    email_uri: str = "smtp://localhost"
+    google_oauth_client_id: str = "client_id"
+    google_oauth_client_secret: str = "client_secret"
+    trailblazer_host: str = "trailblazer_host"
+    trailblazer_service_account: str = "service_account"
+    trailblazer_service_account_auth_file: str = "auth_file.json"
+    freshdesk_url: str = "https://company.freshdesk.com"
+    freshdesk_api_key: str = "freshdesk_api_key"
+    freshdesk_order_email_id: int = 10
+    freshdesk_environment: str = "Stage"
 
 
 app_config = AppConfig()
diff --git a/cg/server/endpoints/orders.py b/cg/server/endpoints/orders.py
index 8261233f47..d2bd64bb15 100644
--- a/cg/server/endpoints/orders.py
+++ b/cg/server/endpoints/orders.py
@@ -28,8 +28,12 @@
 from cg.meta.orders.ticket_handler import TicketHandler
 from cg.models.orders.order import OrderIn, OrderType
 from cg.models.orders.orderform_schema import Orderform
-from cg.server.dto.delivery_message.delivery_message_response import DeliveryMessageResponse
-from cg.server.dto.orders.order_delivery_update_request import OrderDeliveredUpdateRequest
+from cg.server.dto.delivery_message.delivery_message_response import (
+    DeliveryMessageResponse,
+)
+from cg.server.dto.orders.order_delivery_update_request import (
+    OrderDeliveredUpdateRequest,
+)
 from cg.server.dto.orders.order_patch_request import OrderDeliveredPatch
 from cg.server.dto.orders.orders_request import OrdersRequest
 from cg.server.dto.orders.orders_response import Order, OrdersResponse
@@ -39,14 +43,10 @@
     delivery_message_service,
     lims,
     order_service,
-    osticket,
     order_submitter_registry,
+    ticket_handler,
 )
-from cg.store.models import (
-    Application,
-    Customer,
-)
-
+from cg.store.models import Application, Customer
 
 ORDERS_BLUEPRINT = Blueprint("orders", __name__, url_prefix="/api/v1")
 ORDERS_BLUEPRINT.before_request(before_request)
@@ -157,7 +157,10 @@ def create_order_from_form():
 def submit_order(order_type):
     """Submit an order for samples."""
     api = OrdersAPI(
-        lims=lims, status=db, osticket=osticket, submitter_registry=order_submitter_registry
+        lims=lims,
+        status=db,
+        ticket_handler=ticket_handler,
+        submitter_registry=order_submitter_registry,
     )
     error_message: str
     try:
@@ -170,7 +173,7 @@ def submit_order(order_type):
         )
         project = OrderType(order_type)
         order_in = OrderIn.parse_obj(request_json, project=project)
-        existing_ticket: str | None = TicketHandler.parse_ticket_number(order_in.name)
+        existing_ticket: str | None = ticket_handler.parse_ticket_number(order_in.name)
         if existing_ticket and order_service.store.get_order_by_ticket_id(existing_ticket):
             raise OrderExistsError(f"Order with ticket id {existing_ticket} already exists.")
 
diff --git a/cg/server/ext.py b/cg/server/ext.py
index 3200e7742a..c8cfda6286 100644
--- a/cg/server/ext.py
+++ b/cg/server/ext.py
@@ -6,12 +6,11 @@
 from flask_wtf.csrf import CSRFProtect
 
 from cg.apps.lims import LimsAPI
-from cg.apps.osticket import OsTicket
 from cg.apps.tb.api import TrailblazerAPI
+from cg.clients.freshdesk.freshdesk_client import FreshdeskClient
+from cg.meta.orders.ticket_handler import TicketHandler
+from cg.server.app_config import app_config
 from cg.services.delivery_message.delivery_message_service import DeliveryMessageService
-from cg.services.sample_run_metrics_service.sample_run_metrics_service import (
-    SampleRunMetricsService,
-)
 from cg.services.orders.order_service.order_service import OrderService
 from cg.services.orders.order_summary_service.order_summary_service import (
     OrderSummaryService,
@@ -20,6 +19,9 @@
     OrderSubmitterRegistry,
     setup_order_submitter_registry,
 )
+from cg.services.sample_run_metrics_service.sample_run_metrics_service import (
+    SampleRunMetricsService,
+)
 from cg.services.sample_service.sample_service import SampleService
 from cg.store.database import initialize_database
 from cg.store.store import Store
@@ -84,7 +86,6 @@ def init_app(self, app):
 
 admin = Admin(name="Clinical Genomics")
 lims = FlaskLims()
-osticket = OsTicket()
 analysis_client = AnalysisClient()
 delivery_message_service = DeliveryMessageService(store=db, trailblazer_api=analysis_client)
 summary_service = OrderSummaryService(store=db, analysis_client=analysis_client)
@@ -95,3 +96,12 @@ def init_app(self, app):
     lims=lims,
     status_db=db,
 )
+freshdesk_client = FreshdeskClient(
+    base_url=app_config.freshdesk_url, api_key=app_config.freshdesk_api_key
+)
+ticket_handler = TicketHandler(
+    db=db,
+    client=freshdesk_client,
+    system_email_id=app_config.freshdesk_order_email_id,
+    env=app_config.freshdesk_environment,
+)
diff --git a/pyproject.toml b/pyproject.toml
index b2e27b3f36..7cfe49704f 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -4,7 +4,7 @@ build-backend = "poetry.core.masonry.api"
 
 [tool.poetry]
 name = "cg"
-version = "62.2.4"
+version = "62.2.5"
 description = "Clinical Genomics command center"
 authors = ["Clinical Genomics <support@clinicalgenomics.se>"]
 readme = "README.md"
diff --git a/tests/apps/test_osticket.py b/tests/apps/test_osticket.py
deleted file mode 100644
index c16f21b2ca..0000000000
--- a/tests/apps/test_osticket.py
+++ /dev/null
@@ -1,31 +0,0 @@
-""" Test the osticket app """
-
-import logging
-
-import pytest
-
-from cg.apps.osticket import OsTicket
-from cg.exc import TicketCreationError
-
-
-def test_osticket_respone_500(monkeypatch, caplog, response):
-    """Test that we log properly when we get a non successful response"""
-
-    # GIVEN a ticket server always gives a failure in response
-    osticket_api = OsTicket()
-    monkeypatch.setattr("requests.post", lambda *args, **kwargs: response)
-
-    # WHEN we call open_ticket with ok ticket data
-    caplog.set_level(logging.ERROR)
-    with pytest.raises(TicketCreationError):
-        osticket_api.open_ticket(
-            name="dummy_name",
-            email="dummy_email",
-            subject="dummy_subject",
-            message="dummy_message",
-            attachment={},
-        )
-
-    # THEN the response text and reason was logged and a ticket creation error raised
-    assert response.reason in caplog.text
-    assert response.text in caplog.text
diff --git a/tests/conftest.py b/tests/conftest.py
index 8ca5b26c0f..3f4b3bd4bd 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -75,12 +75,12 @@
 from tests.mocks.hk_mock import MockHousekeeperAPI
 from tests.mocks.limsmock import LimsSample, LimsUDF, MockLimsAPI
 from tests.mocks.madeline import MockMadelineAPI
-from tests.mocks.osticket import MockOsTicket
 from tests.mocks.process_mock import ProcessMock
 from tests.mocks.scout import MockScoutAPI
 from tests.mocks.tb_mock import MockTB
 from tests.small_helpers import SmallHelpers
 from tests.store_helpers import StoreHelpers
+from cg.clients.freshdesk.freshdesk_client import FreshdeskClient
 
 LOG = logging.getLogger(__name__)
 multiqc_json_file = "multiqc_data.json"
@@ -645,11 +645,10 @@ def ticket_id() -> str:
 
 
 @pytest.fixture
-def osticket(ticket_id: str) -> MockOsTicket:
-    """Return a api that mock the os ticket api."""
-    api = MockOsTicket()
-    api.set_ticket_nr(ticket_id)
-    return api
+def freshdesk_client() -> FreshdeskClient:
+    """Return a FreshdeskClient instance with mock parameters."""
+    client = FreshdeskClient(base_url="https://mock.freshdesk.com", api_key="mock_api_key")
+    return client
 
 
 # Files fixtures
diff --git a/tests/meta/orders/conftest.py b/tests/meta/orders/conftest.py
index 24add743eb..5857e67a8a 100644
--- a/tests/meta/orders/conftest.py
+++ b/tests/meta/orders/conftest.py
@@ -2,6 +2,7 @@
 
 import pytest
 
+from cg.clients.freshdesk.freshdesk_client import FreshdeskClient
 from cg.meta.orders import OrdersAPI
 from cg.meta.orders.ticket_handler import TicketHandler
 from cg.services.orders.submitters.order_submitter_registry import (
@@ -10,27 +11,31 @@
 )
 from cg.store.store import Store
 from tests.mocks.limsmock import MockLimsAPI
-from tests.mocks.osticket import MockOsTicket
+
+
+@pytest.fixture
+def freshdesk_client():
+    return FreshdeskClient(base_url="https://mock.freshdesk.com", api_key="mock_api_key")
 
 
 @pytest.fixture(scope="function")
 def orders_api(
-    base_store,
-    osticket: MockOsTicket,
+    base_store: Store,
+    ticket_handler: TicketHandler,
     lims_api: MockLimsAPI,
     order_submitter_registry: OrderSubmitterRegistry,
 ) -> OrdersAPI:
     return OrdersAPI(
         lims=lims_api,
         status=base_store,
-        osticket=osticket,
+        ticket_handler=ticket_handler,
         submitter_registry=order_submitter_registry,
     )
 
 
 @pytest.fixture
-def ticket_handler(store: Store, osticket: MockOsTicket) -> TicketHandler:
-    return TicketHandler(status_db=store, osticket_api=osticket)
+def ticket_handler(store: Store, freshdesk_client: FreshdeskClient) -> TicketHandler:
+    return TicketHandler(db=store, client=freshdesk_client, system_email_id=12345, env="production")
 
 
 @pytest.fixture
diff --git a/tests/meta/orders/test_meta_orders_api.py b/tests/meta/orders/test_meta_orders_api.py
index 885753ef03..04ffe40588 100644
--- a/tests/meta/orders/test_meta_orders_api.py
+++ b/tests/meta/orders/test_meta_orders_api.py
@@ -1,8 +1,9 @@
 import datetime as dt
-from unittest.mock import patch, Mock
+from unittest.mock import Mock, patch
 
 import pytest
 
+from cg.clients.freshdesk.models import TicketResponse
 from cg.constants import DataDelivery
 from cg.constants.constants import Workflow
 from cg.constants.subject import Sex
@@ -27,6 +28,22 @@ def monkeypatch_process_lims(monkeypatch, order_data) -> None:
     )
 
 
+def mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id: str):
+    """Helper function to mock Freshdesk ticket creation."""
+    mock_create_ticket.return_value = TicketResponse(
+        id=int(ticket_id),
+        description="This is a test description.",
+        subject="Support needed..",
+        status=2,
+        priority=1,
+    )
+
+
+def mock_freshdesk_reply_to_ticket(mock_reply_to_ticket):
+    """Helper function to mock Freshdesk reply to ticket."""
+    mock_reply_to_ticket.return_value = None
+
+
 def test_too_long_order_name():
     # GIVEN order with more than allowed characters name
     long_name = "A super long order name that is longer than sixty-four characters."
@@ -38,7 +55,6 @@ def test_too_long_order_name():
         OrderIn(name=long_name, customer="", comment="", samples=[])
 
 
-@patch("cg.meta.orders.ticket_handler.FormDataRequest.submit", return_value=None)
 @pytest.mark.parametrize(
     "order_type",
     [
@@ -55,37 +71,44 @@ def test_too_long_order_name():
     ],
 )
 def test_submit(
-    mail_patch,
     all_orders_to_submit: dict,
     base_store: Store,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     ticket_id: str,
     user_mail: str,
     user_name: str,
 ):
-    order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
-    monkeypatch_process_lims(monkeypatch, order_data)
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket"
+    ) as mock_create_ticket, patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.reply_to_ticket"
+    ) as mock_reply_to_ticket:
+        mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id)
+        mock_freshdesk_reply_to_ticket(mock_reply_to_ticket)
 
-    # GIVEN an order and an empty store
-    assert not base_store._get_query(table=Sample).first()
+        order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
+        monkeypatch_process_lims(monkeypatch, order_data)
 
-    # WHEN submitting the order
+        # GIVEN an order and an empty store
+        assert not base_store._get_query(table=Sample).first()
 
-    result = orders_api.submit(
-        project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
-    )
+        # WHEN submitting the order
+
+        result = orders_api.submit(
+            project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
+        )
 
-    # THEN the result should contain the ticket number for the order
-    for record in result["records"]:
-        if isinstance(record, Pool):
-            assert record.ticket == ticket_id
-        elif isinstance(record, Sample):
-            assert record.original_ticket == ticket_id
-        elif isinstance(record, Case):
-            for link_obj in record.links:
-                assert link_obj.sample.original_ticket == ticket_id
+        # THEN the result should contain the ticket number for the order
+        for record in result["records"]:
+            if isinstance(record, Pool):
+                assert record.ticket == ticket_id
+            elif isinstance(record, Sample):
+                assert record.original_ticket == ticket_id
+            elif isinstance(record, Case):
+                for link_obj in record.links:
+                    assert link_obj.sample.original_ticket == ticket_id
 
 
 @pytest.mark.parametrize(
@@ -99,22 +122,24 @@ def test_submit_ticketexception(
     user_mail: str,
     user_name: str,
 ):
-    # GIVEN an order that does not have a name (ticket_nr)
-    order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
-    order_data.name = "dummy_name"
-    with patch("cg.apps.osticket.OsTicket") as os_mock:
-        orders_api.ticket_handler.osticket = os_mock.return_value
-        orders_api.ticket_handler.osticket.open_ticket.side_effect = TicketCreationError("ERROR")
-
-    # WHEN the order is submitted and a TicketCreationError raised
-    # THEN the TicketCreationError is not excepted
-    with pytest.raises(TicketCreationError):
-        orders_api.submit(
-            project=order_type,
-            order_in=order_data,
-            user_name=user_name,
-            user_mail=user_mail,
-        )
+    # GIVEN a mock Freshdesk ticket creation that raises TicketCreationError
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket",
+        side_effect=TicketCreationError("ERROR"),
+    ):
+        # GIVEN an order that does not have a name (ticket_nr)
+        order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
+        order_data.name = "dummy_name"
+
+        # WHEN the order is submitted and a TicketCreationError raised
+        # THEN the TicketCreationError is not excepted
+        with pytest.raises(TicketCreationError):
+            orders_api.submit(
+                project=order_type,
+                order_in=order_data,
+                user_name=user_name,
+                user_mail=user_mail,
+            )
 
 
 @pytest.mark.parametrize(
@@ -123,7 +148,7 @@ def test_submit_ticketexception(
 )
 def test_submit_illegal_sample_customer(
     all_orders_to_submit: dict,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     sample_store: Store,
@@ -132,7 +157,6 @@ def test_submit_illegal_sample_customer(
 ):
     order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
     monkeypatch_process_lims(monkeypatch, order_data)
-    orders_api.ticket_handler = Mock()
     # GIVEN we have an order with a customer that is not in the same customer group as customer
     # that the samples originate from
     new_customer = sample_store.add_customer(
@@ -161,60 +185,65 @@ def test_submit_illegal_sample_customer(
         )
 
 
-@patch("cg.meta.orders.ticket_handler.FormDataRequest.submit", return_value=None)
 @pytest.mark.parametrize(
     "order_type",
     [OrderType.MIP_DNA, OrderType.MIP_RNA, OrderType.BALSAMIC],
 )
 def test_submit_scout_legal_sample_customer(
-    mail_patch,
     all_orders_to_submit: dict,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     sample_store: Store,
     user_mail: str,
     user_name: str,
+    ticket_id: str,
 ):
-    order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
-    monkeypatch_process_lims(monkeypatch, order_data)
-    orders_api.ticket_handler = Mock()
-    # GIVEN we have an order with a customer that is in the same customer group as customer
-    # that the samples originate from
-    collaboration = sample_store.add_collaboration("customer999only", "customer 999 only group")
-    sample_store.session.add(collaboration)
-    sample_customer = sample_store.add_customer(
-        "customer1",
-        "customer 1",
-        scout_access=True,
-        invoice_address="dummy street 1",
-        invoice_reference="dummy nr",
-    )
-    order_customer = sample_store.add_customer(
-        "customer2",
-        "customer 2",
-        scout_access=True,
-        invoice_address="dummy street 2",
-        invoice_reference="dummy nr",
-    )
-    sample_customer.collaborations.append(collaboration)
-    order_customer.collaborations.append(collaboration)
-    sample_store.session.add(sample_customer)
-    sample_store.session.add(order_customer)
-    existing_sample: Sample = sample_store._get_query(table=Sample).first()
-    existing_sample.customer = sample_customer
-    sample_store.session.commit()
-    order_data.customer = order_customer.internal_id
-
-    for sample in order_data.samples:
-        sample.internal_id = existing_sample.internal_id
-        break
-
-    # WHEN calling submit
-    # THEN an OrderError should not be raised on illegal customer
-    orders_api.submit(
-        project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
-    )
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket"
+    ) as mock_create_ticket, patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.reply_to_ticket"
+    ) as mock_reply_to_ticket:
+        mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id)
+        mock_freshdesk_reply_to_ticket(mock_reply_to_ticket)
+        order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
+        monkeypatch_process_lims(monkeypatch, order_data)
+        # GIVEN we have an order with a customer that is in the same customer group as customer
+        # that the samples originate from
+        collaboration = sample_store.add_collaboration("customer999only", "customer 999 only group")
+        sample_store.session.add(collaboration)
+        sample_customer = sample_store.add_customer(
+            "customer1",
+            "customer 1",
+            scout_access=True,
+            invoice_address="dummy street 1",
+            invoice_reference="dummy nr",
+        )
+        order_customer = sample_store.add_customer(
+            "customer2",
+            "customer 2",
+            scout_access=True,
+            invoice_address="dummy street 2",
+            invoice_reference="dummy nr",
+        )
+        sample_customer.collaborations.append(collaboration)
+        order_customer.collaborations.append(collaboration)
+        sample_store.session.add(sample_customer)
+        sample_store.session.add(order_customer)
+        existing_sample: Sample = sample_store._get_query(table=Sample).first()
+        existing_sample.customer = sample_customer
+        sample_store.session.commit()
+        order_data.customer = order_customer.internal_id
+
+        for sample in order_data.samples:
+            sample.internal_id = existing_sample.internal_id
+            break
+
+        # WHEN calling submit
+        # THEN an OrderError should not be raised on illegal customer
+        orders_api.submit(
+            project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
+        )
 
 
 @pytest.mark.parametrize(
@@ -223,7 +252,7 @@ def test_submit_scout_legal_sample_customer(
 )
 def test_submit_duplicate_sample_case_name(
     all_orders_to_submit: dict,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     ticket_id: str,
@@ -234,7 +263,6 @@ def test_submit_duplicate_sample_case_name(
     order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
     store = orders_api.status
     customer: Customer = store.get_customer_by_internal_id(customer_internal_id=order_data.customer)
-    orders_api.ticket_handler = Mock()
     for sample in order_data.samples:
         case_id = sample.family_name
         if not store.get_case_by_name_and_customer(customer=customer, case_name=case_id):
@@ -262,72 +290,85 @@ def test_submit_duplicate_sample_case_name(
         )
 
 
-@patch("cg.meta.orders.ticket_handler.FormDataRequest.submit", return_value=None)
 @pytest.mark.parametrize(
     "order_type",
     [OrderType.FLUFFY],
 )
 def test_submit_fluffy_duplicate_sample_case_name(
-    mail_patch,
     all_orders_to_submit: dict,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     user_mail: str,
     user_name: str,
+    ticket_id: str,
 ):
-    # GIVEN we have an order with a case that is already in the database
-    order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
-    monkeypatch_process_lims(monkeypatch, order_data)
-
-    orders_api.submit(
-        project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
-    )
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket"
+    ) as mock_create_ticket, patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.reply_to_ticket"
+    ) as mock_reply_to_ticket:
+        mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id)
+        mock_freshdesk_reply_to_ticket(mock_reply_to_ticket)
+        # GIVEN we have an order with a case that is already in the database
+        order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
+        monkeypatch_process_lims(monkeypatch, order_data)
 
-    # WHEN calling submit
-    # THEN an OrderError should be raised on duplicate case name
-    with pytest.raises(OrderError):
         orders_api.submit(
-            project=order_type,
-            order_in=order_data,
-            user_name=user_name,
-            user_mail=user_mail,
+            project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
         )
 
+        # WHEN calling submit
+        # THEN an OrderError should be raised on duplicate case name
+        with pytest.raises(OrderError):
+            orders_api.submit(
+                project=order_type,
+                order_in=order_data,
+                user_name=user_name,
+                user_mail=user_mail,
+            )
+
 
-@patch("cg.meta.orders.ticket_handler.FormDataRequest.submit", return_value=None)
 def test_submit_unique_sample_case_name(
-    mail_patch,
     orders_api: OrdersAPI,
     mip_order_to_submit: dict,
     user_name: str,
     user_mail: str,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
+    ticket_id: str,
 ):
-    # GIVEN we have an order with a case that is not existing in the database
-    order_data = OrderIn.parse_obj(obj=mip_order_to_submit, project=OrderType.MIP_DNA)
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket"
+    ) as mock_create_ticket, patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.reply_to_ticket"
+    ) as mock_reply_to_ticket:
+        mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id)
+        mock_freshdesk_reply_to_ticket(mock_reply_to_ticket)
+
+        # GIVEN we have an order with a case that is not existing in the database
+        order_data = OrderIn.parse_obj(obj=mip_order_to_submit, project=OrderType.MIP_DNA)
+
+        store = orders_api.status
+
+        sample: MipDnaSample
+        for sample in order_data.samples:
+            case_id = sample.family_name
+            customer: Customer = store.get_customer_by_internal_id(
+                customer_internal_id=order_data.customer
+            )
+            assert not store.get_case_by_name_and_customer(customer=customer, case_name=case_id)
 
-    store = orders_api.status
+        monkeypatch_process_lims(monkeypatch, order_data)
 
-    sample: MipDnaSample
-    for sample in order_data.samples:
-        case_id = sample.family_name
-        customer: Customer = store.get_customer_by_internal_id(
-            customer_internal_id=order_data.customer
+        # WHEN calling submit
+        orders_api.submit(
+            project=OrderType.MIP_DNA,
+            order_in=order_data,
+            user_name=user_name,
+            user_mail=user_mail,
         )
-        assert not store.get_case_by_name_and_customer(customer=customer, case_name=case_id)
-
-    monkeypatch_process_lims(monkeypatch, order_data)
 
-    # WHEN calling submit
-    orders_api.submit(
-        project=OrderType.MIP_DNA,
-        order_in=order_data,
-        user_name=user_name,
-        user_mail=user_mail,
-    )
-
-    # Then no exception about duplicate names should be thrown
+        # Then no exception about duplicate names should be thrown
 
 
 def test_validate_sex_inconsistent_sex(
@@ -454,7 +495,6 @@ def test_validate_sex_unknown_new_sex(
     # THEN no OrderError should be raised on non-matching sex
 
 
-@patch("cg.meta.orders.ticket_handler.FormDataRequest.submit", return_value=None)
 @pytest.mark.parametrize(
     "order_type",
     [
@@ -470,27 +510,34 @@ def test_validate_sex_unknown_new_sex(
     ],
 )
 def test_submit_unique_sample_name(
-    mail_patch,
     all_orders_to_submit: dict,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     user_mail: str,
     user_name: str,
+    ticket_id: str,
 ):
-    # GIVEN we have an order with a sample that is not existing in the database
-    order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
-    store = orders_api.status
-    assert not store._get_query(table=Sample).first()
-
-    monkeypatch_process_lims(monkeypatch, order_data)
-
-    # WHEN calling submit
-    orders_api.submit(
-        project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
-    )
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket"
+    ) as mock_create_ticket, patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.reply_to_ticket"
+    ) as mock_reply_to_ticket:
+        mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id)
+        mock_freshdesk_reply_to_ticket(mock_reply_to_ticket)
+        # GIVEN we have an order with a sample that is not existing in the database
+        order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
+        store = orders_api.status
+        assert not store._get_query(table=Sample).first()
+
+        monkeypatch_process_lims(monkeypatch, order_data)
+
+        # WHEN calling submit
+        orders_api.submit(
+            project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
+        )
 
-    # Then no exception about duplicate names should be thrown
+        # Then no exception about duplicate names should be thrown
 
 
 @pytest.mark.parametrize(
@@ -500,7 +547,7 @@ def test_submit_unique_sample_name(
 def test_sarscov2_submit_duplicate_sample_name(
     all_orders_to_submit: dict,
     helpers: StoreHelpers,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
     user_mail: str,
@@ -536,7 +583,6 @@ def store_samples_with_names_from_order(store: Store, helpers: StoreHelpers, ord
             store.session.commit()
 
 
-@patch("cg.meta.orders.ticket_handler.FormDataRequest.submit", return_value=None)
 @pytest.mark.parametrize(
     "order_type",
     [
@@ -549,24 +595,30 @@ def store_samples_with_names_from_order(store: Store, helpers: StoreHelpers, ord
     ],
 )
 def test_not_sarscov2_submit_duplicate_sample_name(
-    mail_patch,
     all_orders_to_submit: dict,
     helpers: StoreHelpers,
-    monkeypatch,
+    monkeypatch: pytest.MonkeyPatch,
     order_type: OrderType,
     orders_api: OrdersAPI,
-    sample_store: Store,
     user_mail: str,
     user_name: str,
+    ticket_id: str,
 ):
-    # GIVEN we have an order with samples that is already in the database
-    order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
-    monkeypatch_process_lims(monkeypatch, order_data)
-    store_samples_with_names_from_order(orders_api.status, helpers, order_data)
-
-    # WHEN calling submit
-    orders_api.submit(
-        project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
-    )
+    with patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.create_ticket"
+    ) as mock_create_ticket, patch(
+        "cg.clients.freshdesk.freshdesk_client.FreshdeskClient.reply_to_ticket"
+    ) as mock_reply_to_ticket:
+        mock_freshdesk_ticket_creation(mock_create_ticket, ticket_id)
+        mock_freshdesk_reply_to_ticket(mock_reply_to_ticket)
+        # GIVEN we have an order with samples that is already in the database
+        order_data = OrderIn.parse_obj(obj=all_orders_to_submit[order_type], project=order_type)
+        monkeypatch_process_lims(monkeypatch, order_data)
+        store_samples_with_names_from_order(orders_api.status, helpers, order_data)
+
+        # WHEN calling submit
+        orders_api.submit(
+            project=order_type, order_in=order_data, user_name=user_name, user_mail=user_mail
+        )
 
-    # THEN no OrderError should be raised on duplicate sample name
+        # THEN no OrderError should be raised on duplicate sample name
diff --git a/tests/mocks/osticket.py b/tests/mocks/osticket.py
deleted file mode 100644
index 7ed223fc44..0000000000
--- a/tests/mocks/osticket.py
+++ /dev/null
@@ -1,54 +0,0 @@
-"""Mock the os ticket api"""
-
-import logging
-import os.path
-
-from flask import Flask
-
-from cg.apps.osticket import OsTicket
-from cg.exc import TicketCreationError
-
-LOG = logging.getLogger(__name__)
-
-
-class MockOsTicket(OsTicket):
-    """Interface to ticket system."""
-
-    def __init__(self):
-        self.headers = None
-        self.url = None
-        self.osticket_email = "james.holden@scilifelab.se"
-        self.mail_container_uri = "dummy_uri"
-        self._ticket_nr: str = "123456"
-        self._should_fail: bool = False
-        self._return_none: bool = False
-        self.email_uri = "http://localhost:0000/sendmail"
-
-    def set_ticket_nr(self, ticket_id: str) -> None:
-        self._ticket_nr = ticket_id
-
-    def init_app(self, app: Flask):
-        """Initialize the API in Flask."""
-
-    def setup(
-        self,
-        api_key: str = None,
-        domain: str = None,
-        osticket_email: str = None,
-        email_uri: str = None,
-    ):
-        """Initialize the API."""
-        self.headers = {"X-API-Key": api_key}
-        self.url = os.path.join(domain, "api/tickets.json")
-
-    def open_ticket(
-        self, attachment: dict, email: str, message: str, name: str, subject: str
-    ) -> str | None:
-        """Open a new ticket through the REST API."""
-        if self._should_fail:
-            LOG.error("res.text: %s, reason: %s", self._ticket_nr, "Unknown reason")
-            raise TicketCreationError("FAIL")
-        if self._return_none:
-            return None
-
-        return self._ticket_nr
diff --git a/tests/server/conftest.py b/tests/server/conftest.py
index b0f1e107a4..2c1290e47b 100644
--- a/tests/server/conftest.py
+++ b/tests/server/conftest.py
@@ -28,9 +28,6 @@
 os.environ["TRAILBLAZER_HOST"] = "dummy_value"
 os.environ["CG_SECRET_KEY"] = "dummy_value"
 os.environ["GUNICORN_BIND"] = "0.0.0.0:8000"
-os.environ["OSTICKET_API_KEY"] = "dummy_value"
-os.environ["OSTICKET_API_URL"] = "dummy_value"
-os.environ["OSTICKET_DOMAIN"] = "dummy_value"
 os.environ["SUPPORT_SYSTEM_EMAIL"] = "dummy_value"
 os.environ["EMAIL_URI"] = "dummy_value"