diff --git a/README.md b/README.md new file mode 100644 index 0000000..a1552cf --- /dev/null +++ b/README.md @@ -0,0 +1,16 @@ +# NM-Imaging + +This repository hosts the notebooks and scripts that we'll be using to simulate the NM imaging pipeline: starting from neuron activity to the generated df/f signal. +The main goal is to assess how the calculation of f can affect the df/f signal produced. This calculation of f + +- Simulation.ipynb is the notebook with the documentation of this NM imaging model +- Simulation.py will the script that calls the functions in Functions.py + +This repository is still new, so there's probably still errors in the code -- if you find some please raise an issue and we can resolve it. + +**Specifics on the simulation** + +We're modelling (simulating) the dynamics of neuromodulator concentration [x] and neuromodulator bound to sensor [x s] and to receptor [x r]. +This is equivalent to intracellular calcium measurements in the presence of endogenous ca buffers and exogenous buffers (the sensors). +Here, we assume that we are dealing with one compartment in equilibrium to start and everything is linear, including uptake. +The Source of x is a train of spikes, each producing a fixed delta_x.